LRGB_BACAN
ID LRGB_BACAN Reviewed; 230 AA.
AC Q81JL5; Q6HQ58; Q6KJJ9;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Antiholin-like protein LrgB {ECO:0000255|HAMAP-Rule:MF_01142};
GN Name=lrgB {ECO:0000255|HAMAP-Rule:MF_01142};
GN OrderedLocusNames=BA_5689, GBAA_5689, BAS5293;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits the expression or activity of extracellular murein
CC hydrolases by interacting, possibly with LrgA, with the holin-like
CC protein CidA. The LrgAB and CidA proteins may affect the proton motive
CC force of the membrane. May be involved in programmed cell death (PCD),
CC possibly triggering PCD in response to antibiotics and environmental
CC stresses. {ECO:0000255|HAMAP-Rule:MF_01142}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01142};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01142}.
CC -!- SIMILARITY: Belongs to the CidB/LrgB family. LrgB subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01142}.
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DR EMBL; AE016879; AAP29321.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT34845.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT57580.1; -; Genomic_DNA.
DR RefSeq; NP_847835.1; NC_003997.3.
DR RefSeq; WP_000168869.1; NZ_WXXJ01000017.1.
DR RefSeq; YP_031530.1; NC_005945.1.
DR AlphaFoldDB; Q81JL5; -.
DR STRING; 260799.BAS5293; -.
DR DNASU; 1085429; -.
DR EnsemblBacteria; AAP29321; AAP29321; BA_5689.
DR EnsemblBacteria; AAT34845; AAT34845; GBAA_5689.
DR GeneID; 59156928; -.
DR GeneID; 64200538; -.
DR GeneID; 67510063; -.
DR KEGG; ban:BA_5689; -.
DR KEGG; bar:GBAA_5689; -.
DR KEGG; bat:BAS5293; -.
DR PATRIC; fig|198094.11.peg.5651; -.
DR eggNOG; COG1346; Bacteria.
DR HOGENOM; CLU_082099_1_0_9; -.
DR OMA; PLHTAYA; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-UniRule.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01142; LrgB; 1.
DR InterPro; IPR024891; Antiholin-like_LrgB.
DR InterPro; IPR007300; CidB/LrgB.
DR PANTHER; PTHR30249; PTHR30249; 1.
DR Pfam; PF04172; LrgB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytolysis; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..230
FT /note="Antiholin-like protein LrgB"
FT /id="PRO_0000217053"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 32..54
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 64..81
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 94..116
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 143..165
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 178..197
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 207..229
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
SQ SEQUENCE 230 AA; 24349 MW; 709D16B9CB6B2C4C CRC64;
MASTMTPYFG IVVSLIAYGI GTLLFKHSKG FFLFTPLFVA MVLGIVFLKV GNFTFEEYNT
GGKMISFFLE PATIAFAIPL YKQVDKLKKY WWQILSAIVV GSICSVIVVF IVAKAIGLDT
AVMNSMLPQA ATTAIALPIS ESIGGIPAIT SFAVIFNAVI VYALGALFLK TFRVKHPIAK
GLALGTAGHA LGVAVGIEMG EVEAAMASIA VTVVGVVTVV VIPMFMPFIG
