LRGB_STAAT
ID LRGB_STAAT Reviewed; 233 AA.
AC A8Z0M6;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Antiholin-like protein LrgB {ECO:0000255|HAMAP-Rule:MF_01142};
GN Name=lrgB {ECO:0000255|HAMAP-Rule:MF_01142};
GN OrderedLocusNames=USA300HOU_0274;
OS Staphylococcus aureus (strain USA300 / TCH1516).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=451516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300 / TCH1516;
RX PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA Mason E.O. Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y., Igboeli O.,
RA Petrosino J., Tirumalai M., Uzman A., Fox G.E., Cardenas A.M., Muzny D.M.,
RA Hemphill L., Ding Y., Dugan S., Blyth P.R., Buhay C.J., Dinh H.H.,
RA Hawes A.C., Holder M., Kovar C.L., Lee S.L., Liu W., Nazareth L.V.,
RA Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT "Subtle genetic changes enhance virulence of methicillin resistant and
RT sensitive Staphylococcus aureus.";
RL BMC Microbiol. 7:99-99(2007).
CC -!- FUNCTION: Inhibits the expression or activity of extracellular murein
CC hydrolases by interacting, possibly with LrgA, with the holin-like
CC proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the
CC proton motive force of the membrane. May be involved in programmed cell
CC death (PCD), possibly triggering PCD in response to antibiotics and
CC environmental stresses. {ECO:0000255|HAMAP-Rule:MF_01142}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01142};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01142}.
CC -!- SIMILARITY: Belongs to the CidB/LrgB family. LrgB subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01142}.
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DR EMBL; CP000730; ABX28305.1; -; Genomic_DNA.
DR RefSeq; WP_000607067.1; NC_010079.1.
DR AlphaFoldDB; A8Z0M6; -.
DR KEGG; sax:USA300HOU_0274; -.
DR HOGENOM; CLU_082099_1_0_9; -.
DR OMA; PLHTAYA; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-UniRule.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01142; LrgB; 1.
DR InterPro; IPR024891; Antiholin-like_LrgB.
DR InterPro; IPR007300; CidB/LrgB.
DR PANTHER; PTHR30249; PTHR30249; 1.
DR Pfam; PF04172; LrgB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytolysis; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..233
FT /note="Antiholin-like protein LrgB"
FT /id="PRO_1000085035"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
SQ SEQUENCE 233 AA; 25097 MW; 089E84B7C8246C4E CRC64;
MINHLALNTP YFGILLSVIP FFLATILFEK TNRFFLFAPL FVSMVFGVAF LYLTGIPYKT
YKIGGDIIYF FLEPATICFA IPLYKKREVL VKHWHRIIGG IGIGTVVALL IILTFAKLAQ
FANDVILSML PQAATTAIAL PVSAGIGGIK ELTSLAVILN GVIIYALGNK FLKLFRITNP
IARGLALGTS GHTLGVAPAK ELGPVEESMA SIALVLVGVV VVAVVPVFVA IFF
