LRGB_STAES
ID LRGB_STAES Reviewed; 233 AA.
AC Q8CN53;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Antiholin-like protein LrgB {ECO:0000255|HAMAP-Rule:MF_01142};
GN Name=lrgB {ECO:0000255|HAMAP-Rule:MF_01142}; OrderedLocusNames=SE_2014;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- FUNCTION: Inhibits the expression or activity of extracellular murein
CC hydrolases by interacting, possibly with LrgA, with the holin-like
CC proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the
CC proton motive force of the membrane. May be involved in programmed cell
CC death (PCD), possibly triggering PCD in response to antibiotics and
CC environmental stresses. {ECO:0000255|HAMAP-Rule:MF_01142}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01142};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01142}.
CC -!- SIMILARITY: Belongs to the CidB/LrgB family. LrgB subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01142}.
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DR EMBL; AE015929; AAO05655.1; -; Genomic_DNA.
DR RefSeq; NP_765569.1; NC_004461.1.
DR RefSeq; WP_001831408.1; NZ_WBME01000003.1.
DR AlphaFoldDB; Q8CN53; -.
DR STRING; 176280.SE_2014; -.
DR EnsemblBacteria; AAO05655; AAO05655; SE_2014.
DR KEGG; sep:SE_2014; -.
DR PATRIC; fig|176280.10.peg.1967; -.
DR eggNOG; COG1346; Bacteria.
DR HOGENOM; CLU_082099_1_0_9; -.
DR OMA; PLHTAYA; -.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-UniRule.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01142; LrgB; 1.
DR InterPro; IPR024891; Antiholin-like_LrgB.
DR InterPro; IPR007300; CidB/LrgB.
DR PANTHER; PTHR30249; PTHR30249; 1.
DR Pfam; PF04172; LrgB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytolysis; Membrane; Transmembrane; Transmembrane helix.
FT CHAIN 1..233
FT /note="Antiholin-like protein LrgB"
FT /id="PRO_0000217063"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01142"
SQ SEQUENCE 233 AA; 24754 MW; 5C0E2CF725B06AC4 CRC64;
MIEHLGINTP YFGILVSLIP FVIATYFYKK TNGFFLLAPL FVSMVAGIAF LKLTGISYEN
YKIGGDIINF FLEPATICFA IPLYRKREVL KRYWLQIFGG IAVGTIIALL LIYLVAITFQ
FGNQIIASML PQAATTAIAL PVSDGIGGVK ELTSLAVILN AVVISALGAK IVKLFKISNP
IARGLALGTS GHTLGVAAAK ELGETEESMG SIAVVIVGVI VVAVVPILAP ILL
