ID   LRHA_ECO57              Reviewed;         312 AA.
AC   Q8VWE6;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Probable HTH-type transcriptional regulator LrhA;
GN   Name=lrhA; OrderedLocusNames=Z3549, ECs3173;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Not known, does not seem to act on the proton translocating
CC       NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE005174; AAG57418.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36596.1; -; Genomic_DNA.
DR   PIR; E91025; E91025.
DR   PIR; F85869; F85869.
DR   RefSeq; NP_311200.1; NC_002695.1.
DR   RefSeq; WP_000622284.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8VWE6; -.
DR   SMR; Q8VWE6; -.
DR   STRING; 155864.EDL933_3453; -.
DR   EnsemblBacteria; AAG57418; AAG57418; Z3549.
DR   EnsemblBacteria; BAB36596; BAB36596; ECs_3173.
DR   GeneID; 916881; -.
DR   KEGG; ece:Z3549; -.
DR   KEGG; ecs:ECs_3173; -.
DR   PATRIC; fig|386585.9.peg.3311; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_1_3_6; -.
DR   OMA; RTWRITC; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..312
FT                   /note="Probable HTH-type transcriptional regulator LrhA"
FT                   /id="PRO_0000105664"
FT   DOMAIN          11..68
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        28..47
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   312 AA;  34562 MW;  98A5F2236690C38C CRC64;
     MISANRPIIN LDLDLLRTFV AVADLNTFAA AAAAVCRTQS AVSQQMQRLE QLVGKELFAR
     HGRNKLLTEH GIQLLGYARK ILRFNDEACS SLMFSNLQGV LTIGASDESA DTILPFLLNR
     VSSVYPKLAL DVRVKRNAYM AEMLESQEVD LMVTTHRPSA FKALNLRTSP THWYCAAEYV
     LQKGEPIPLV LLDDPSPFRD MVLATLNKAD IPWRLAYVAS TLPAVRAAVK AGLGVTARPV
     EMMSPDLRVL SGVDGLPPLP DTEYLLCYDP SSNNELAQVI YQAMESYHNP WQYSPISAPE
     GDDSLLIERD IE