LRHA_ECOLI
ID LRHA_ECOLI Reviewed; 312 AA.
AC P36771; P76490; P76934;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Probable HTH-type transcriptional regulator LrhA;
GN Name=lrhA; Synonyms=genR; OrderedLocusNames=b2289, JW2284;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=7565112; DOI=10.1111/j.1365-2958.1995.tb02416.x;
RA Bongaerts J., Zoske S., Weidner U., Unden G.;
RT "Transcriptional regulation of the proton translocating NADH dehydrogenase
RT genes (nuoA-N) of Escherichia coli by electron acceptors, electron donors
RT and gene regulators.";
RL Mol. Microbiol. 16:521-534(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- FUNCTION: Not known, does not seem to act on the proton translocating
CC NADH dehydrogenase genes (nuoA-N) which are part of the lrhA operon.
CC -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC {ECO:0000305}.
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DR EMBL; X74546; CAA52637.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75349.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16124.2; -; Genomic_DNA.
DR PIR; G65000; G65000.
DR RefSeq; NP_416792.1; NC_000913.3.
DR RefSeq; WP_000622280.1; NZ_LN832404.1.
DR AlphaFoldDB; P36771; -.
DR SMR; P36771; -.
DR BioGRID; 4262973; 16.
DR BioGRID; 851110; 1.
DR IntAct; P36771; 1.
DR STRING; 511145.b2289; -.
DR jPOST; P36771; -.
DR PaxDb; P36771; -.
DR PRIDE; P36771; -.
DR EnsemblBacteria; AAC75349; AAC75349; b2289.
DR EnsemblBacteria; BAA16124; BAA16124; BAA16124.
DR GeneID; 946769; -.
DR KEGG; ecj:JW2284; -.
DR KEGG; eco:b2289; -.
DR PATRIC; fig|1411691.4.peg.4446; -.
DR EchoBASE; EB2044; -.
DR eggNOG; COG0583; Bacteria.
DR HOGENOM; CLU_039613_1_3_6; -.
DR InParanoid; P36771; -.
DR OMA; RTWRITC; -.
DR PhylomeDB; P36771; -.
DR BioCyc; EcoCyc:EG12123-MON; -.
DR PHI-base; PHI:7647; -.
DR PRO; PR:P36771; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:EcoCyc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:EcoliWiki.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEP:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IDA:EcoCyc.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR005119; LysR_subst-bd.
DR InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00126; HTH_1; 1.
DR Pfam; PF03466; LysR_substrate; 1.
DR PRINTS; PR00039; HTHLYSR.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50931; HTH_LYSR; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..312
FT /note="Probable HTH-type transcriptional regulator LrhA"
FT /id="PRO_0000105663"
FT DOMAIN 11..68
FT /note="HTH lysR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT DNA_BIND 28..47
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT CONFLICT 291..312
FT /note="WQYSPMSAPEGDDSLLIERDIE -> CNTAQCLLRKGMIH (in Ref. 1;
FT CAA52637)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 34594 MW; 9FC82A806CA3D11C CRC64;
MISANRPIIN LDLDLLRTFV AVADLNTFAA AAAAVCRTQS AVSQQMQRLE QLVGKELFAR
HGRNKLLTEH GIQLLGYARK ILRFNDEACS SLMFSNLQGV LTIGASDESA DTILPFLLNR
VSSVYPKLAL DVRVKRNAYM AEMLESQEVD LMVTTHRPSA FKALNLRTSP THWYCAAEYI
LQKGEPIPLV LLDDPSPFRD MVLATLNKAD IPWRLAYVAS TLPAVRAAVK AGLGVTARPV
EMMSPDLRVL SGVDGLPPLP DTEYLLCYDP SSNNELAQVI YQAMESYHNP WQYSPMSAPE
GDDSLLIERD IE
