LRIQ1_MOUSE
ID LRIQ1_MOUSE Reviewed; 1673 AA.
AC Q0P5X1; Q3TYL6; Q9CUK8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Leucine-rich repeat and IQ domain-containing protein 1;
GN Name=Lrriq1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-520 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0P5X1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0P5X1-2; Sequence=VSP_040541, VSP_040542;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE34547.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC122850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC162918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC051400; AAH51400.1; -; mRNA.
DR EMBL; AK015687; BAB29931.1; -; mRNA.
DR EMBL; AK158531; BAE34547.1; ALT_FRAME; mRNA.
DR CCDS; CCDS48686.1; -. [Q0P5X1-2]
DR CCDS; CCDS48687.1; -. [Q0P5X1-1]
DR RefSeq; NP_001157031.1; NM_001163559.1. [Q0P5X1-1]
DR RefSeq; NP_083410.1; NM_029134.2. [Q0P5X1-2]
DR RefSeq; XP_006514322.1; XM_006514259.2. [Q0P5X1-1]
DR RefSeq; XP_006514325.1; XM_006514262.2.
DR AlphaFoldDB; Q0P5X1; -.
DR SMR; Q0P5X1; -.
DR BioGRID; 217124; 2.
DR STRING; 10090.ENSMUSP00000020043; -.
DR iPTMnet; Q0P5X1; -.
DR PhosphoSitePlus; Q0P5X1; -.
DR jPOST; Q0P5X1; -.
DR MaxQB; Q0P5X1; -.
DR PaxDb; Q0P5X1; -.
DR PeptideAtlas; Q0P5X1; -.
DR PRIDE; Q0P5X1; -.
DR ProteomicsDB; 292035; -. [Q0P5X1-1]
DR ProteomicsDB; 292036; -. [Q0P5X1-2]
DR Antibodypedia; 52101; 18 antibodies from 9 providers.
DR Ensembl; ENSMUST00000020043; ENSMUSP00000020043; ENSMUSG00000019892. [Q0P5X1-2]
DR Ensembl; ENSMUST00000166240; ENSMUSP00000131419; ENSMUSG00000019892. [Q0P5X1-1]
DR GeneID; 74978; -.
DR KEGG; mmu:74978; -.
DR UCSC; uc007gyi.1; mouse. [Q0P5X1-2]
DR UCSC; uc011xmu.1; mouse. [Q0P5X1-1]
DR CTD; 84125; -.
DR MGI; MGI:1922228; Lrriq1.
DR VEuPathDB; HostDB:ENSMUSG00000019892; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00940000162858; -.
DR HOGENOM; CLU_002837_0_0_1; -.
DR InParanoid; Q0P5X1; -.
DR OMA; SHTEEHN; -.
DR OrthoDB; 433355at2759; -.
DR PhylomeDB; Q0P5X1; -.
DR TreeFam; TF333460; -.
DR BioGRID-ORCS; 74978; 8 hits in 72 CRISPR screens.
DR ChiTaRS; Lrriq1; mouse.
DR PRO; PR:Q0P5X1; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q0P5X1; protein.
DR Bgee; ENSMUSG00000019892; Expressed in spermatid and 41 other tissues.
DR ExpressionAtlas; Q0P5X1; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51450; LRR; 10.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..1673
FT /note="Leucine-rich repeat and IQ domain-containing protein
FT 1"
FT /id="PRO_0000313626"
FT REPEAT 34..59
FT /note="LRR 1"
FT REPEAT 216..239
FT /note="LRR 2"
FT DOMAIN 291..320
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REPEAT 491..516
FT /note="LRR 3"
FT REPEAT 641..665
FT /note="LRR 4"
FT REPEAT 830..852
FT /note="LRR 5"
FT REPEAT 853..873
FT /note="LRR 6"
FT REPEAT 874..894
FT /note="LRR 7"
FT REPEAT 895..919
FT /note="LRR 8"
FT REPEAT 921..939
FT /note="LRR 9"
FT REPEAT 940..961
FT /note="LRR 10"
FT REPEAT 962..983
FT /note="LRR 11"
FT REPEAT 984..1005
FT /note="LRR 12"
FT REPEAT 1007..1029
FT /note="LRR 13"
FT REPEAT 1030..1054
FT /note="LRR 14"
FT REPEAT 1067..1090
FT /note="LRR 15"
FT DOMAIN 1280..1309
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1340..1369
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REPEAT 1378..1405
FT /note="LRR 16"
FT REGION 22..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1172..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1308..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 812..814
FT /note="PVI -> FII (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040541"
FT VAR_SEQ 815..1673
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040542"
FT CONFLICT 295
FT /note="A -> T (in Ref. 3; BAB29931)"
FT /evidence="ECO:0000305"
FT CONFLICT 489
FT /note="E -> G (in Ref. 3; BAE34547)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1673 AA; 191812 MW; CD250CA5016CC782 CRC64;
MEDSDDSEAK LREEIEAELD KISISSLEND EVENDSVSDT QSDSSDTDLL ELPESVLHYI
NVIKNKSKTA EELILQDVED TDIFSDYKKG CNHGTVTDSH MHLRTGSLPE SKANAEQLMK
ILSVIEKEEF MRSLAPSARC VSVREIITPD TPMDEYILPD EADLSFGYFE VEERCRKSFE
AWQDKQQELE EKDKETLEAQ NEREKRTFQE EDEKRQCWMR QFEVEKKHLE DLQKQDQDKM
NDELHKEEKI WKEKYRQHEE HIRNLHLKME EERTRLSELQ EKEKARLFKL RYDAAVKIQA
TYRASVTYRK YSPIIKEQME KKRRRAQELK EKEAKIRQKE EEKRRRLEEE QRVEEEKKKK
MLEERRRRER EYEEKKSILR QEREEQRSKE VIRLREHAHS PLIITCALKK GDCHGKQQAI
AHVPKGKGTI AKESVDSNSK KQEDACLAQQ LNKRENTHVQ QLAMKKSTGI KLKPNQAILV
ELKMNEKNES LPKLKINENL SKNQCSEQPS DQEFNAENVD QKNELENSNL KESVNEQYPW
QGLESDTQTE EHVEHVREEK VGQETEKLFG FNQEVSAEDS KQAQGVMEET REGLAEEIEI
KEMTQQGGPS DENNSSPISM QKSLPSLTPD NPEPVERSVT LEEDQETDLK SERIEEIPEE
GVLSCDAAVI NADASVHTEG EADLQDSASG KLAPSEEAGS HSANNLLATE EVEDSPKSEI
QEALEKGQQT KAEADGVLTC SVSQLTVLSS VEERRLAWVK TFKPWAEIFE QNQHKKIVKK
RRLVKCPPNT MPPLDPSAIL QYGPWKSLKQ VPVITFQGLP GCSLSTLAEC SNLQILSLRR
CGLTSLQGLS HCTRLKYIDA QENHIEAISC ENLENLSVVL LNNNLLTSIH GFDGCTNLQS
LELSHNKITR ISGLESLKYL QELTVDHNQL ISTKGLCEAP TIVYLDCSHN HLTGIDGIGN
CGLLQIIKLQ GNYLREPPSL RNHVLLRELH LDDNSISSVE GLSSCWLPLL QYLSISQNSL
ATIVPLFHLV SLEKLDVSNN CLSDLTNVMC WFNACYSLRE LCLTGNPVLQ EINWRDSILK
TLPALRVLNG DMLNSYANDR IEEHYHQDLR CLLALCQYQL QEFNLLPEKY ITQKRDILTL
HAVDRLSQYY KDLMKLSHEC RRAHEQGDVN TTERSAAETN KNHPDFSNTD SALQNKTLHA
QTNSCEADSP ATSPNPLDTV FRPSTSHCEE LRGRNQEKLM AHKSEQSRIS SRSNSRASFI
EMKMADSPMS NHHNAERSSP TKAAMVIQAQ WRSYIAHRQI NCSAEMHPTT TEPLQDPLIN
NQTTSNEERR KTNMDIQEQR EKAALHIQAV WKGFILRKKL ATARKAIKDE ESGEEYEEID
LEDFEFDEDA LEKDWPALDS TGFPSQTLPL SNQLPWPKNS RTLRHDETSP TIPVRPAQAW
LCNEKENVMS SEYTQLSSRS ESGILSWTPD SKTSRKNLLQ SEKEEKISEE WGFKDISTAQ
QMLKRAKKMK SKKLRKKLEP SVRLALFKKA KNKVSVTKSS KKTQLRRDNY FEAHISSQDE
EEEAVSKATA AKEKLERSQE YTYQWLHTQV GFPEATSSRN LKCNHFLPEL DPDVLNGGRV
QLVARLVSRE DTDLDLFSMT SASALSVNKD KKSQTHRYST GSSSKLWFPS ELI
