LRIQ3_MOUSE
ID LRIQ3_MOUSE Reviewed; 633 AA.
AC Q14DL3; Q9D4C3; Q9D562; Q9D5I0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Leucine-rich repeat and IQ domain-containing protein 3;
DE AltName: Full=Leucine-rich repeat-containing protein 44;
GN Name=Lrriq3; Synonyms=Lrrc44;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Oviduct, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q14DL3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q14DL3-2; Sequence=VSP_029412, VSP_029413;
CC Name=3;
CC IsoId=Q14DL3-3; Sequence=VSP_029414, VSP_029415;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB30350.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK015333; BAB29800.1; -; mRNA.
DR EMBL; AK015758; BAB29962.1; -; mRNA.
DR EMBL; AK016634; BAB30350.1; ALT_FRAME; mRNA.
DR EMBL; BC112424; AAI12425.1; -; mRNA.
DR EMBL; BC113130; AAI13131.1; -; mRNA.
DR CCDS; CCDS38682.1; -. [Q14DL3-1]
DR RefSeq; NP_083214.2; NM_028938.2. [Q14DL3-1]
DR RefSeq; XP_006502252.1; XM_006502189.2. [Q14DL3-1]
DR RefSeq; XP_006502253.1; XM_006502190.3. [Q14DL3-2]
DR AlphaFoldDB; Q14DL3; -.
DR BioGRID; 216745; 1.
DR STRING; 10090.ENSMUSP00000029833; -.
DR iPTMnet; Q14DL3; -.
DR PhosphoSitePlus; Q14DL3; -.
DR PaxDb; Q14DL3; -.
DR PRIDE; Q14DL3; -.
DR ProteomicsDB; 292037; -. [Q14DL3-1]
DR ProteomicsDB; 292038; -. [Q14DL3-2]
DR ProteomicsDB; 292039; -. [Q14DL3-3]
DR Antibodypedia; 33447; 108 antibodies from 15 providers.
DR DNASU; 74435; -.
DR Ensembl; ENSMUST00000029833; ENSMUSP00000029833; ENSMUSG00000028182. [Q14DL3-1]
DR Ensembl; ENSMUST00000192383; ENSMUSP00000141372; ENSMUSG00000028182. [Q14DL3-2]
DR Ensembl; ENSMUST00000194376; ENSMUSP00000142127; ENSMUSG00000028182. [Q14DL3-3]
DR GeneID; 74435; -.
DR KEGG; mmu:74435; -.
DR UCSC; uc008ruw.1; mouse. [Q14DL3-3]
DR UCSC; uc008rux.1; mouse. [Q14DL3-1]
DR CTD; 127255; -.
DR MGI; MGI:1921685; Lrriq3.
DR VEuPathDB; HostDB:ENSMUSG00000028182; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00390000004404; -.
DR HOGENOM; CLU_029934_0_0_1; -.
DR InParanoid; Q14DL3; -.
DR OMA; FATHPKQ; -.
DR OrthoDB; 795526at2759; -.
DR PhylomeDB; Q14DL3; -.
DR TreeFam; TF329557; -.
DR BioGRID-ORCS; 74435; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Lrriq3; mouse.
DR PRO; PR:Q14DL3; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q14DL3; protein.
DR Bgee; ENSMUSG00000028182; Expressed in spermatid and 105 other tissues.
DR Genevisible; Q14DL3; MM.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12799; LRR_4; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51450; LRR; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Leucine-rich repeat; Reference proteome;
KW Repeat.
FT CHAIN 1..633
FT /note="Leucine-rich repeat and IQ domain-containing protein
FT 3"
FT /id="PRO_0000311195"
FT REPEAT 51..72
FT /note="LRR 1"
FT REPEAT 73..94
FT /note="LRR 2"
FT REPEAT 98..119
FT /note="LRR 3"
FT DOMAIN 132..179
FT /note="LRRCT"
FT DOMAIN 215..244
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 324..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 556..617
FT /evidence="ECO:0000255"
FT VAR_SEQ 291..300
FT /note="MRYSPADFKY -> DKTKLWVNFH (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029414"
FT VAR_SEQ 301..633
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029415"
FT VAR_SEQ 335..345
FT /note="QKAMKAESEDE -> LEGFKCSFLDA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029412"
FT VAR_SEQ 346..633
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029413"
FT CONFLICT 19
FT /note="Y -> H (in Ref. 1; BAB30350)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 633 AA; 75364 MW; 735C8884E9E95605 CRC64;
MFHGTITKEL TSHEEWSHYN ENIIEDQKDF VFVKYSGLHL KSMENLQTCI SLRVCIFSNN
FLTDIQPLQS CKKLIKLDLH GNQIKTLPDK NFWSGLKNLK LLYLHDNGFS KLKNICVLSG
CVSLIGLTMF DCPVSLKKGY RHVLVNSIWP LKALDHHVIS DEEIIQNWRL PERFKTFSPS
LFFNLYPALI KGTTYEDEIK NIKHIISRIN EILAHNSPVL IIQRWIRGFI VRKHLSPYFK
HKKHYHGKMI RVLETKLICI GRSDEDKYLE DFFFIKPECN IKGKVAHWKQ MRYSPADFKY
STEYGKHISC LSYELKTKYI DGKSKQPRHH IHKGQKAMKA ESEDEEVDTE FRISAMKIPL
YSSRSLKYGA MLKEMKWDYF PQYLQPFPAT RQKPPVKRET LWKLKKRREF LATQRAGMKL
HMFDDVDKYY SEQKQHEEEA RKFAAMVTAQ VTQERASVNI REKLNKKIYM TRKLMEKDNE
TIQKGLQQIW RERLAYLEKV RERKFMFLAE KKLNAADQSL VISLNNERSI LLKGITQVER
LKKHMSEKKA KHLDVIEKWE EQKYKQDLLM EMKKLRVEEI QKRHCEEKFV IDTLILQKGY
ERLEEAKAKV EYIKTFYTSK SHKRRNEAMP DHI
