LRIQ4_HUMAN
ID LRIQ4_HUMAN Reviewed; 560 AA.
AC A6NIV6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Leucine-rich repeat and IQ domain-containing protein 4;
DE AltName: Full=Leucine-rich repeat-containing protein 64;
GN Name=LRRIQ4; Synonyms=LRRC64;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
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DR EMBL; AC078795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46951.1; -.
DR RefSeq; NP_001073929.1; NM_001080460.1.
DR RefSeq; XP_005247478.1; XM_005247421.2.
DR RefSeq; XP_006713676.1; XM_006713613.3.
DR RefSeq; XP_011511050.1; XM_011512748.1.
DR AlphaFoldDB; A6NIV6; -.
DR SMR; A6NIV6; -.
DR BioGRID; 131313; 2.
DR IntAct; A6NIV6; 2.
DR MINT; A6NIV6; -.
DR STRING; 9606.ENSP00000342188; -.
DR iPTMnet; A6NIV6; -.
DR PhosphoSitePlus; A6NIV6; -.
DR BioMuta; LRRIQ4; -.
DR MassIVE; A6NIV6; -.
DR PaxDb; A6NIV6; -.
DR PeptideAtlas; A6NIV6; -.
DR PRIDE; A6NIV6; -.
DR Antibodypedia; 64434; 57 antibodies from 12 providers.
DR DNASU; 344657; -.
DR Ensembl; ENST00000340806.7; ENSP00000342188.6; ENSG00000188306.7.
DR GeneID; 344657; -.
DR KEGG; hsa:344657; -.
DR MANE-Select; ENST00000340806.7; ENSP00000342188.6; NM_001080460.3; NP_001073929.1.
DR UCSC; uc003fgb.4; human.
DR CTD; 344657; -.
DR DisGeNET; 344657; -.
DR GeneCards; LRRIQ4; -.
DR HGNC; HGNC:34298; LRRIQ4.
DR HPA; ENSG00000188306; Tissue enriched (testis).
DR neXtProt; NX_A6NIV6; -.
DR PharmGKB; PA162394647; -.
DR VEuPathDB; HostDB:ENSG00000188306; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161601; -.
DR HOGENOM; CLU_000288_18_23_1; -.
DR InParanoid; A6NIV6; -.
DR OMA; PPKEVCA; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; A6NIV6; -.
DR TreeFam; TF351429; -.
DR PathwayCommons; A6NIV6; -.
DR SignaLink; A6NIV6; -.
DR BioGRID-ORCS; 344657; 13 hits in 1063 CRISPR screens.
DR GenomeRNAi; 344657; -.
DR Pharos; A6NIV6; Tdark.
DR PRO; PR:A6NIV6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A6NIV6; protein.
DR Bgee; ENSG00000188306; Expressed in rectum and 26 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 15.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51450; LRR; 17.
PE 4: Predicted;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..560
FT /note="Leucine-rich repeat and IQ domain-containing protein
FT 4"
FT /id="PRO_0000332138"
FT REPEAT 23..47
FT /note="LRR 1"
FT REPEAT 48..70
FT /note="LRR 2"
FT REPEAT 72..95
FT /note="LRR 3"
FT REPEAT 97..116
FT /note="LRR 4"
FT REPEAT 117..140
FT /note="LRR 5"
FT REPEAT 141..164
FT /note="LRR 6"
FT REPEAT 166..187
FT /note="LRR 7"
FT REPEAT 188..210
FT /note="LRR 8"
FT REPEAT 212..233
FT /note="LRR 9"
FT REPEAT 234..256
FT /note="LRR 10"
FT REPEAT 258..281
FT /note="LRR 11"
FT REPEAT 283..301
FT /note="LRR 12"
FT REPEAT 302..325
FT /note="LRR 13"
FT REPEAT 326..348
FT /note="LRR 14"
FT REPEAT 350..371
FT /note="LRR 15"
FT REPEAT 374..397
FT /note="LRR 16"
FT REPEAT 398..422
FT /note="LRR 17"
FT REPEAT 424..443
FT /note="LRR 18"
FT REPEAT 444..466
FT /note="LRR 19"
FT REPEAT 468..489
FT /note="LRR 20"
FT DOMAIN 504..533
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 159
FT /note="K -> E (in dbSNP:rs16854411)"
FT /id="VAR_042953"
SQ SEQUENCE 560 AA; 63977 MW; B5D04894F014040A CRC64;
MSKDIKSVEH SPKIHQRNDP QHVNDRTFFI DASNQSLTAI PLEIFTFTEL EEVHLENNQI
EEIPQEIQRL KNIRVLYLDK NNLRSLCPAL GLLSSLESLD LSYNPIFSSS LVVVSFLHAL
RELRLYQTDL KEIPVVIFKN LHHLELLGLT GNHLKCLPKE IVNQTKLREI YLKRNQFEVF
PQELCVLYTL EIIDLDENKI GAIPEEIGHL TGLQKFYMAS NNLPVLPASL CQCSQLSVLD
LSHNLLHSIP KSFAELRKMT EIGLSGNRLE KVPRLICRWT SLHLLYLGNT GLHRLRGSFR
CLVNLRFLDL SQNHLHHCPL QICALKNLEV LGLDDNKIGQ LPSELGSLSK LKILGLTGNE
FLSFPEEVLS LASLEKLYIG QDQGFKLTYV PEHIRKLQSL KELYIENNHL EYLPVSLGSM
PNLEVLDCRH NLLKQLPDAI CQAQALKELR LEDNLLTHLP ENLDSLVNLK VLTLMDNPME
EPPKEVCAEG NEAIWKYLKE NRNRNIMATK IQAWWRGTMV QRGFGKFGEL LKPQKKGKTS
PKDKKGKKDV KGKPGKGKKK
