LRIQ4_MOUSE
ID LRIQ4_MOUSE Reviewed; 596 AA.
AC A6H6A4; Q9D5Q5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Leucine-rich repeat and IQ domain-containing protein 4;
GN Name=Lrriq4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6H6A4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6H6A4-2; Sequence=VSP_033339;
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DR EMBL; AK015024; BAB29680.1; -; mRNA.
DR EMBL; BC145806; AAI45807.1; -; mRNA.
DR CCDS; CCDS38406.1; -. [A6H6A4-1]
DR CCDS; CCDS71229.1; -. [A6H6A4-2]
DR RefSeq; NP_001277439.1; NM_001290510.1. [A6H6A4-2]
DR RefSeq; NP_080944.2; NM_026668.2. [A6H6A4-1]
DR AlphaFoldDB; A6H6A4; -.
DR SMR; A6H6A4; -.
DR STRING; 10090.ENSMUSP00000103902; -.
DR PhosphoSitePlus; A6H6A4; -.
DR PaxDb; A6H6A4; -.
DR PRIDE; A6H6A4; -.
DR ProteomicsDB; 292040; -. [A6H6A4-1]
DR ProteomicsDB; 292041; -. [A6H6A4-2]
DR Antibodypedia; 64434; 57 antibodies from 12 providers.
DR DNASU; 68307; -.
DR Ensembl; ENSMUST00000108265; ENSMUSP00000103900; ENSMUSG00000027703. [A6H6A4-2]
DR Ensembl; ENSMUST00000108267; ENSMUSP00000103902; ENSMUSG00000027703. [A6H6A4-1]
DR Ensembl; ENSMUST00000172350; ENSMUSP00000127052; ENSMUSG00000027703. [A6H6A4-1]
DR GeneID; 68307; -.
DR KEGG; mmu:68307; -.
DR UCSC; uc008ovc.1; mouse. [A6H6A4-1]
DR UCSC; uc008ovd.2; mouse. [A6H6A4-2]
DR CTD; 344657; -.
DR MGI; MGI:1915557; Lrriq4.
DR VEuPathDB; HostDB:ENSMUSG00000027703; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161601; -.
DR HOGENOM; CLU_000288_18_23_1; -.
DR InParanoid; A6H6A4; -.
DR OMA; PPKEVCA; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; A6H6A4; -.
DR TreeFam; TF351429; -.
DR BioGRID-ORCS; 68307; 1 hit in 72 CRISPR screens.
DR PRO; PR:A6H6A4; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; A6H6A4; protein.
DR Bgee; ENSMUSG00000027703; Expressed in spermatid and 7 other tissues.
DR Genevisible; A6H6A4; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00369; LRR_TYP; 13.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51450; LRR; 17.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..596
FT /note="Leucine-rich repeat and IQ domain-containing protein
FT 4"
FT /id="PRO_0000332139"
FT REPEAT 22..44
FT /note="LRR 1"
FT REPEAT 59..83
FT /note="LRR 2"
FT REPEAT 84..106
FT /note="LRR 3"
FT REPEAT 108..129
FT /note="LRR 4"
FT REPEAT 130..152
FT /note="LRR 5"
FT REPEAT 153..176
FT /note="LRR 6"
FT REPEAT 177..200
FT /note="LRR 7"
FT REPEAT 202..223
FT /note="LRR 8"
FT REPEAT 224..246
FT /note="LRR 9"
FT REPEAT 248..269
FT /note="LRR 10"
FT REPEAT 270..293
FT /note="LRR 11"
FT REPEAT 295..315
FT /note="LRR 12"
FT REPEAT 317..337
FT /note="LRR 13"
FT REPEAT 338..361
FT /note="LRR 14"
FT REPEAT 362..384
FT /note="LRR 15"
FT REPEAT 385..407
FT /note="LRR 16"
FT REPEAT 410..433
FT /note="LRR 17"
FT REPEAT 434..457
FT /note="LRR 18"
FT REPEAT 459..479
FT /note="LRR 19"
FT REPEAT 480..502
FT /note="LRR 20"
FT REPEAT 504..525
FT /note="LRR 21"
FT REPEAT 527..549
FT /note="LRR 22"
FT DOMAIN 540..569
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 569..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..596
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..25
FT /note="MHHSSSGSRCVLQNGLELTVILPRL -> MAYPSAKLQM (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033339"
SQ SEQUENCE 596 AA; 68010 MW; 040BCA23D412537E CRC64;
MHHSSSGSRC VLQNGLELTV ILPRLHRFDI IDTFKTLTKE LLRQEHLPKV LQKKEPHQLT
DRTFFIDGSN QGLKTIPSEI LALKELEEVH LENNQIAEIP QGIQQLQNTK VLYLHNNSLQ
DLCPELGALS SLESLDLSGN PLVISSLHVV SRLRTLRELR LYRTGLTEIP TGICKSLHHL
ELFGLSENFL ESLPEEIVNQ TKLREIYLKQ NHFEVFPCDL CVLYNLEVID LDENKLKSIP
GDIGHLVRLQ KFYVASNHLM SLPESLSQCS KLSVLDLTHN SIHSLPSSLE LLTELTEVGL
SGNRLEKVPR LLCSWVSLHL LYLRNTSLHG LRDSFKRLIN LRFLDLSQNH IEHFPVQICA
LKNLEILALD DNKVRQLPPS ISLLSNLKIL GLTGNDLLSF PEEIFSLISL EKLYIGQDQG
SKLSSLPENI KRLMNLKELY IENNRLEQLP ASLGLMPNLE VLDCRHNLLK QLPDAICRTR
NLRELLLEDN LLCCLPENLD HLVNLKVLTL MNNPMVDPPI YVCNQGNEAI WKHLKENRIR
KMMATTIQAW WRGIMVRKGY GSYEELLKAR KKGKSPPKDK KGKKAAKGKP EKGNKK
