LRIT1_MOUSE
ID LRIT1_MOUSE Reviewed; 624 AA.
AC Q8K099; Q8BXN3;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1;
DE AltName: Full=Leucine-rich repeat-containing protein 21;
DE AltName: Full=Photoreceptor-associated LRR superfamily protein;
DE AltName: Full=Retina-specific protein PAL;
DE Flags: Precursor;
GN Name=Lrit1; Synonyms=Lrrc21, Pal;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Possible role in phototransduction.
CC {ECO:0000250|UniProtKB:Q9JMH2}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9JMH2}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC32010.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK044631; BAC32010.1; ALT_INIT; mRNA.
DR EMBL; BC032270; AAH32270.2; -; mRNA.
DR CCDS; CCDS26950.2; -.
DR RefSeq; NP_666357.2; NM_146245.2.
DR AlphaFoldDB; Q8K099; -.
DR SMR; Q8K099; -.
DR STRING; 10090.ENSMUSP00000113964; -.
DR GlyGen; Q8K099; 3 sites.
DR iPTMnet; Q8K099; -.
DR PhosphoSitePlus; Q8K099; -.
DR PaxDb; Q8K099; -.
DR PeptideAtlas; Q8K099; -.
DR PRIDE; Q8K099; -.
DR ProteomicsDB; 292042; -.
DR Antibodypedia; 48882; 67 antibodies from 13 providers.
DR DNASU; 239037; -.
DR Ensembl; ENSMUST00000120052; ENSMUSP00000113964; ENSMUSG00000041044.
DR GeneID; 239037; -.
DR KEGG; mmu:239037; -.
DR UCSC; uc007tbr.2; mouse.
DR CTD; 26103; -.
DR MGI; MGI:2385320; Lrit1.
DR VEuPathDB; HostDB:ENSMUSG00000041044; -.
DR eggNOG; KOG0619; Eukaryota.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000156033; -.
DR HOGENOM; CLU_019650_0_0_1; -.
DR InParanoid; Q8K099; -.
DR OMA; RKEQCII; -.
DR OrthoDB; 316687at2759; -.
DR PhylomeDB; Q8K099; -.
DR TreeFam; TF330861; -.
DR BioGRID-ORCS; 239037; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8K099; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8K099; protein.
DR Bgee; ENSMUSG00000041044; Expressed in retinal neural layer and 10 other tissues.
DR Genevisible; Q8K099; MM.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISO:MGI.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Disulfide bond; Endoplasmic reticulum; Glycoprotein; Immunoglobulin domain;
KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..624
FT /note="Leucine-rich repeat, immunoglobulin-like domain and
FT transmembrane domain-containing protein 1"
FT /id="PRO_0000014836"
FT TOPO_DOM 22..527
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 549..624
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..59
FT /note="LRRNT"
FT REPEAT 60..81
FT /note="LRR 1"
FT REPEAT 84..105
FT /note="LRR 2"
FT REPEAT 108..129
FT /note="LRR 3"
FT REPEAT 132..153
FT /note="LRR 4"
FT REPEAT 156..177
FT /note="LRR 5"
FT DOMAIN 201..254
FT /note="LRRCT"
FT DOMAIN 267..336
FT /note="Ig-like C2-type"
FT DOMAIN 431..519
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REPEAT 526..549
FT /note="LRR 6"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 297
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 456
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 276..329
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 65
FT /note="R -> C (in Ref. 1; BAC32010)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 624 AA; 68464 MW; 6114A1138AEED8D5 CRC64;
MWVALGMLWL LALGGPHQAW GFCPSECSCS LRILSDGSKA RTVVCSDPDL TLPPASIPPD
TCKLRLERTA IRRVPGETFR PLSRLEQLWL PYNALSELSA LMLRGLRRLR ELRLPGNRLV
TFPWAALRDT PQLQLLDLQA NRLSTLPPEA AHFLENLTFL DLSNNQLMRL PEELLDVWAH
LKTGPFLSGH HARLILGLQD NPWVCDCRLY DLVHLLDGWV SSNLIFIEAR LRCASPRSLA
GVAFSQLELR KCQSPELRPG VTSIISPLGS TVLLRCGATG IPGPEMSWRR ANGRPLNGTV
HQEVSSDGSS WTLLDLPVVS LFDSGDYICQ AKNFLGASET LISLIVTEPQ TSTGYSGIPG
VLWARTGEGA EAAAYNNKLV ARHVPHMPEH VALATKPSMP SIKEELALQN FQMDVPGEFS
REPSEHQEAQ MVRSLKVVGD TYHSVSLVWK APQAGNTTAF SVLYAVFGHR DMRRMTVEPG
KTSVTIEGLA PKTKYVACVC VRGLVPTKEQ CVIFSTDEVV DAEGTQRLIN MVVISVAAII
ALPPTLLVCC GALRRRCHKC RTGGSAEASG AYVNLERLGH SEDSSEVLSR SSLSEGDRLL
SARSSLDSQV LGVRGGRRIN EYFC
