ID   LRIT2_DANRE             Reviewed;         561 AA.
AC   Q504C1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=lrit2; ORFNames=zgc:109962;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH95086.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC095086; AAH95086.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001018372.2; NM_001020536.1.
DR   AlphaFoldDB; Q504C1; -.
DR   SMR; Q504C1; -.
DR   STRING; 7955.ENSDARP00000036969; -.
DR   PaxDb; Q504C1; -.
DR   GeneID; 553557; -.
DR   KEGG; dre:553557; -.
DR   CTD; 340745; -.
DR   ZFIN; ZDB-GENE-050522-160; lrit2.
DR   eggNOG; KOG0619; Eukaryota.
DR   InParanoid; Q504C1; -.
DR   OrthoDB; 770995at2759; -.
DR   PhylomeDB; Q504C1; -.
DR   PRO; PR:Q504C1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Leucine-rich repeat; Membrane;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..561
FT                   /note="Leucine-rich repeat, immunoglobulin-like domain and
FT                   transmembrane domain-containing protein 2"
FT                   /id="PRO_0000309346"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          22..54
FT                   /note="LRRNT"
FT   REPEAT          55..76
FT                   /note="LRR 1"
FT   REPEAT          79..102
FT                   /note="LRR 2"
FT   REPEAT          103..124
FT                   /note="LRR 3"
FT   REPEAT          127..150
FT                   /note="LRR 4"
FT   REPEAT          151..172
FT                   /note="LRR 5"
FT   DOMAIN          197..249
FT                   /note="LRRCT"
FT   DOMAIN          250..342
FT                   /note="Ig-like"
FT   DOMAIN          364..449
FT                   /note="Fibronectin type-III"
FT   REGION          507..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        271..324
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   561 AA;  62615 MW;  00697DF3122738FA CRC64;
     MDVCVLFHLI VFCILISHIS SECFPGCSCG TDRHGRSLTC METALTGIPD GLPEDLTKIR
     IEKSQLSELP EAVFSHVKAL KHLWLNFNDI AIINIKSLEG LANLTELRLQ GNKLRSVPWT
     AFEETPNLKI LDLKHNRIDA LPEHALKFLP GLTYLDLSSN QLSVISKDVF LNWPLYHSEN
     KHEKPSASNV VLALHDNPWL CDCRLGGFIE FIKSLTPPFI LMNSYLTCSS PELKAGRFFH
     EVDLKTCVKP VVSAPVITIT APLGGNVTLT CSASARPEAV IRWIYALKML RGFRDILSHV
     DEDTISSQLV IPSLHSADRG LYTCIANNFL GNSSVIISVD VKSPEGSSSH PSGPSAAIGE
     ENVYIDIRIA KQTVYGITIE WRAVTENPAE TWFTIHFGRY DAVKKEQIYI GPGINTYSVT
     DLLPATKYEI CVTLKNQAPR IGQCIVFVTG SDFNEMEQRE KLIHIVVIVL AMVLAVPAGM
     YACTTDAKFN CFERCAELWR NRRHAELSNP TGDRQGTFDS LQAASDEGLY KESNKDKKAR
     RRSAEKIHKT KNDRRPTAEL Y