ID   LRIT2_MOUSE             Reviewed;         549 AA.
AC   Q6PFC5;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 2;
DE   AltName: Full=Leucine-rich repeat-containing protein 22;
DE   Flags: Precursor;
GN   Name=Lrit2; Synonyms=Lrrc22;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR   EMBL; BC057628; AAH57628.1; -; mRNA.
DR   CCDS; CCDS26951.1; -.
DR   RefSeq; NP_775594.1; NM_173418.3.
DR   AlphaFoldDB; Q6PFC5; -.
DR   SMR; Q6PFC5; -.
DR   STRING; 10090.ENSMUSP00000056642; -.
DR   GlyGen; Q6PFC5; 3 sites.
DR   iPTMnet; Q6PFC5; -.
DR   PhosphoSitePlus; Q6PFC5; -.
DR   PaxDb; Q6PFC5; -.
DR   PRIDE; Q6PFC5; -.
DR   ProteomicsDB; 287272; -.
DR   Antibodypedia; 48881; 12 antibodies from 7 providers.
DR   DNASU; 239038; -.
DR   Ensembl; ENSMUST00000057176; ENSMUSP00000056642; ENSMUSG00000043418.
DR   GeneID; 239038; -.
DR   KEGG; mmu:239038; -.
DR   UCSC; uc007tbs.1; mouse.
DR   CTD; 340745; -.
DR   MGI; MGI:2444885; Lrit2.
DR   VEuPathDB; HostDB:ENSMUSG00000043418; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000159143; -.
DR   HOGENOM; CLU_034556_1_0_1; -.
DR   InParanoid; Q6PFC5; -.
DR   OMA; GITLEWH; -.
DR   OrthoDB; 770995at2759; -.
DR   PhylomeDB; Q6PFC5; -.
DR   TreeFam; TF330861; -.
DR   BioGRID-ORCS; 239038; 2 hits in 72 CRISPR screens.
DR   PRO; PR:Q6PFC5; -.
DR   Proteomes; UP000000589; Chromosome 14.
DR   RNAct; Q6PFC5; protein.
DR   Bgee; ENSMUSG00000043418; Expressed in retinal neural layer and 9 other tissues.
DR   Genevisible; Q6PFC5; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 2.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW   Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..549
FT                   /note="Leucine-rich repeat, immunoglobulin-like domain and
FT                   transmembrane domain-containing protein 2"
FT                   /id="PRO_0000309345"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          23..54
FT                   /note="LRRNT"
FT   REPEAT          80..103
FT                   /note="LRR 1"
FT   REPEAT          104..125
FT                   /note="LRR 2"
FT   REPEAT          128..149
FT                   /note="LRR 3"
FT   REPEAT          152..173
FT                   /note="LRR 4"
FT   DOMAIN          200..252
FT                   /note="LRRCT"
FT   DOMAIN          253..339
FT                   /note="Ig-like"
FT   DOMAIN          361..447
FT                   /note="Fibronectin type-III"
FT   REGION          521..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        523..549
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        261
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        491
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        274..327
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   549 AA;  61360 MW;  93FB6A794FF10B57 CRC64;
     MAFVFYCFLQ VLVSWVIHAV QPFCLPECTC SEESFGRSLQ CMSMSLGKIP DNFPEELKQV
     RIENSPLFEL SQGFFTNMSS LEYLWLNFNN VTVIHLGALE DLPELRELRL EGNKLRSVPW
     TAFRATPLLR VLDLKHNRID SVPELALQFL TNLIYLDISS NRLTVVSKGV FLNWPAYQKR
     QQLGCGAEFL SNMVLSLHNN PWLCDCRLRG LAQFVKSVGP PFILVNSYLV CQGPVSKAGQ
     LLHETELGVC MKPTISTPSV NVTIQVGKNV TLQCFAQASP SPTIAWKYPL STWREFDVLA
     SPIAEGIILS QLVIPAAQLV DGGNYTCMAF NSIGRSSLVI LLYVQPAQAM PGLHFLSTSS
     EVSAYVDLRV VKQTVHGILL QWLTVTNLAE EQWFTLYITS DEALRKKVVH IGPGINTYAV
     DDLLPATKYK ACLSLRNQPP SQGQCVVFVT GKDSGGLEGR EHLLHVTVVL CAVLLALPVG
     AYVWVSQGPY NFSEWCWRRC PLHRKTLRCP QAVPQCKDNS FKDPSGVYED GESHRVMEED
     EEVEKEGIS