5HT7R_MOUSE
ID 5HT7R_MOUSE Reviewed; 448 AA.
AC P32304; Q14A50;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=5-hydroxytryptamine receptor 7;
DE Short=5-HT-7;
DE Short=5-HT7;
DE AltName: Full=5-HT-X;
DE AltName: Full=Serotonin receptor 7;
GN Name=Htr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8394987;
RA Plassat J.-L., Amlaiky N., Hen R.;
RT "Molecular cloning of a mammalian serotonin receptor that activates
RT adenylate cyclase.";
RL Mol. Pharmacol. 44:229-236(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: This is one of the several different receptors for 5-
CC hydroxytryptamine (serotonin), a biogenic hormone that functions as a
CC neurotransmitter, a hormone, and a mitogen. The activity of this
CC receptor is mediated by G proteins that stimulate adenylate cyclase.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; Z23107; CAA80654.1; -; mRNA.
DR EMBL; CH466534; EDL41763.1; -; Genomic_DNA.
DR EMBL; BC116986; AAI16987.1; -; mRNA.
DR CCDS; CCDS29769.1; -.
DR PIR; I48779; S36402.
DR RefSeq; NP_032341.2; NM_008315.2.
DR AlphaFoldDB; P32304; -.
DR SMR; P32304; -.
DR STRING; 10090.ENSMUSP00000126847; -.
DR BindingDB; P32304; -.
DR ChEMBL; CHEMBL4764; -.
DR DrugCentral; P32304; -.
DR GuidetoPHARMACOLOGY; 12; -.
DR GlyGen; P32304; 2 sites.
DR iPTMnet; P32304; -.
DR PhosphoSitePlus; P32304; -.
DR SwissPalm; P32304; -.
DR PaxDb; P32304; -.
DR PRIDE; P32304; -.
DR ProteomicsDB; 285691; -.
DR Antibodypedia; 16324; 436 antibodies from 36 providers.
DR DNASU; 15566; -.
DR Ensembl; ENSMUST00000164639; ENSMUSP00000126847; ENSMUSG00000024798.
DR GeneID; 15566; -.
DR KEGG; mmu:15566; -.
DR UCSC; uc008hhd.1; mouse.
DR CTD; 3363; -.
DR MGI; MGI:99841; Htr7.
DR VEuPathDB; HostDB:ENSMUSG00000024798; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01010000222287; -.
DR InParanoid; P32304; -.
DR OMA; GFPRPEK; -.
DR PhylomeDB; P32304; -.
DR TreeFam; TF331895; -.
DR Reactome; R-MMU-390666; Serotonin receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-9706019; RHOBTB3 ATPase cycle.
DR BioGRID-ORCS; 15566; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Htr7; mouse.
DR PRO; PR:P32304; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; P32304; protein.
DR Bgee; ENSMUSG00000024798; Expressed in medial dorsal nucleus of thalamus and 125 other tissues.
DR ExpressionAtlas; P32304; baseline and differential.
DR Genevisible; P32304; MM.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR GO; GO:0006939; P:smooth muscle contraction; IEA:InterPro.
DR GO; GO:0042310; P:vasoconstriction; IEA:InterPro.
DR InterPro; IPR001069; 5HT_7_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00652; 5HT7RECEPTR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..448
FT /note="5-hydroxytryptamine receptor 7"
FT /id="PRO_0000068980"
FT TOPO_DOM 1..84
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 85..111
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 112..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 122..147
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 148..159
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 160..181
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 182..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 202..225
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 226..240
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 241..263
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 264..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 332..355
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 356..367
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 368..390
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 391..448
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT LIPID 404
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 158..234
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 114..115
FT /note="KL -> NV (in Ref. 1; CAA80654)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="L -> P (in Ref. 1; CAA80654)"
FT /evidence="ECO:0000305"
FT CONFLICT 321
FT /note="I -> S (in Ref. 1; CAA80654)"
FT /evidence="ECO:0000305"
FT CONFLICT 388
FT /note="A -> S (in Ref. 1; CAA80654)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 448 AA; 49916 MW; 85A525FD90792CB1 CRC64;
MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS GFPEVTASPA
PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA GNCLVVISVC FVKKLRQPSN
YLIVSLALAD LSVAVAVMPF VSVTDLIGGK WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS
IDRYLGITRP LTYPVRQNGK CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF
GYTIYSTAVA FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK
EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS TARPFICGTS
CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS LLQCQYRNIN RKLSAAGMHE
ALKLAERPER SEFVLQNCDH CGKKGHDT
