LRMDA_MOUSE
ID LRMDA_MOUSE Reviewed; 229 AA.
AC Q9D9B4;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Leucine-rich melanocyte differentiation-associated protein;
GN Name=Lrmda {ECO:0000312|MGI:MGI:1923883};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for melanocyte differentiation.
CC {ECO:0000250|UniProtKB:Q9H2I8}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK007175; BAB24884.1; -; mRNA.
DR CCDS; CCDS49415.1; -.
DR RefSeq; NP_082551.1; NM_028275.1.
DR AlphaFoldDB; Q9D9B4; -.
DR SMR; Q9D9B4; -.
DR STRING; 10090.ENSMUSP00000075065; -.
DR iPTMnet; Q9D9B4; -.
DR PhosphoSitePlus; Q9D9B4; -.
DR MaxQB; Q9D9B4; -.
DR PaxDb; Q9D9B4; -.
DR PRIDE; Q9D9B4; -.
DR ProteomicsDB; 292043; -.
DR Antibodypedia; 64297; 9 antibodies from 5 providers.
DR Ensembl; ENSMUST00000075639; ENSMUSP00000075065; ENSMUSG00000063458.
DR GeneID; 76633; -.
DR KEGG; mmu:76633; -.
DR UCSC; uc007slz.2; mouse.
DR CTD; 83938; -.
DR MGI; MGI:1923883; Lrmda.
DR VEuPathDB; HostDB:ENSMUSG00000063458; -.
DR eggNOG; KOG1644; Eukaryota.
DR GeneTree; ENSGT00940000153289; -.
DR InParanoid; Q9D9B4; -.
DR OrthoDB; 1133053at2759; -.
DR PhylomeDB; Q9D9B4; -.
DR TreeFam; TF328882; -.
DR BioGRID-ORCS; 76633; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Lrmda; mouse.
DR PRO; PR:Q9D9B4; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9D9B4; protein.
DR Bgee; ENSMUSG00000063458; Expressed in ear vesicle and 116 other tissues.
DR ExpressionAtlas; Q9D9B4; baseline and differential.
DR Genevisible; Q9D9B4; MM.
DR GO; GO:0030318; P:melanocyte differentiation; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR043313; LRMDA.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR46282; PTHR46282; 1.
DR PROSITE; PS51450; LRR; 3.
PE 1: Evidence at protein level;
KW Differentiation; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..229
FT /note="Leucine-rich melanocyte differentiation-associated
FT protein"
FT /id="PRO_0000089782"
FT REPEAT 32..53
FT /note="LRR 1"
FT REPEAT 54..75
FT /note="LRR 2"
FT REPEAT 76..97
FT /note="LRR 3"
FT DOMAIN 121..162
FT /note="LRRCT"
FT REGION 174..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 229 AA; 25989 MW; 20093E8A27B0AC23 CRC64;
MAGLMVSGTQ VSYVGQSCRE IPEHLGRDFG HFAKRLDLSF NLLRSLEGLS AFRSLEELIL
DNNLLGDDLV LPGLPHLHTL TLNKNQITDL EYLLDHLAEV TPSLEYLSLL GNVACPNELV
NLEKDEEDYK RYRCFVLHKL PKLKFLDAQK VTRQEREEAL VRGAFMKVVK PKASSEEEKA
AAPENQPQYT PLPSGSRDLT SHRGVLGKGR YFYYGRNSEG NRFIRDDQL
