LRN4L_HUMAN
ID LRN4L_HUMAN Reviewed; 238 AA.
AC Q8ND94; A8K5L9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=LRRN4 C-terminal-like protein;
DE Flags: Precursor;
GN Name=LRRN4CL; ORFNames=UNQ728/PRO1410;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY358354; AAQ88720.1; -; mRNA.
DR EMBL; AK291334; BAF84023.1; -; mRNA.
DR EMBL; AL834319; CAD38988.1; -; mRNA.
DR EMBL; BC053902; AAH53902.1; -; mRNA.
DR CCDS; CCDS8030.1; -.
DR RefSeq; NP_981967.1; NM_203422.3.
DR AlphaFoldDB; Q8ND94; -.
DR SMR; Q8ND94; -.
DR BioGRID; 128684; 71.
DR IntAct; Q8ND94; 1.
DR STRING; 9606.ENSP00000325808; -.
DR GlyGen; Q8ND94; 1 site.
DR PhosphoSitePlus; Q8ND94; -.
DR BioMuta; LRRN4CL; -.
DR DMDM; 74760169; -.
DR jPOST; Q8ND94; -.
DR MassIVE; Q8ND94; -.
DR PaxDb; Q8ND94; -.
DR PeptideAtlas; Q8ND94; -.
DR PRIDE; Q8ND94; -.
DR ProteomicsDB; 72993; -.
DR Antibodypedia; 28669; 90 antibodies from 19 providers.
DR DNASU; 221091; -.
DR Ensembl; ENST00000317449.5; ENSP00000325808.4; ENSG00000177363.5.
DR GeneID; 221091; -.
DR KEGG; hsa:221091; -.
DR MANE-Select; ENST00000317449.5; ENSP00000325808.4; NM_203422.4; NP_981967.1.
DR UCSC; uc001nun.3; human.
DR CTD; 221091; -.
DR DisGeNET; 221091; -.
DR GeneCards; LRRN4CL; -.
DR HGNC; HGNC:33724; LRRN4CL.
DR HPA; ENSG00000177363; Low tissue specificity.
DR neXtProt; NX_Q8ND94; -.
DR OpenTargets; ENSG00000177363; -.
DR PharmGKB; PA162394685; -.
DR VEuPathDB; HostDB:ENSG00000177363; -.
DR eggNOG; ENOG502S59T; Eukaryota.
DR GeneTree; ENSGT00940000162696; -.
DR HOGENOM; CLU_093350_0_0_1; -.
DR InParanoid; Q8ND94; -.
DR OMA; SCSALVW; -.
DR OrthoDB; 1177486at2759; -.
DR PhylomeDB; Q8ND94; -.
DR PathwayCommons; Q8ND94; -.
DR SignaLink; Q8ND94; -.
DR BioGRID-ORCS; 221091; 17 hits in 1065 CRISPR screens.
DR GenomeRNAi; 221091; -.
DR Pharos; Q8ND94; Tdark.
DR PRO; PR:Q8ND94; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8ND94; protein.
DR Bgee; ENSG00000177363; Expressed in decidua and 131 other tissues.
DR Genevisible; Q8ND94; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..238
FT /note="LRRN4 C-terminal-like protein"
FT /id="PRO_0000317752"
FT TOPO_DOM 23..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 82..176
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 34
FT /note="D -> N (in Ref. 2; BAF84023)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 238 AA; 25262 MW; C7300A7D5A9E3095 CRC64;
MLGSPCLLWL LAVTFLVPRA QPLAPQDFEE EEADETETAW PPLPAVPCDY DHCRHLQVPC
KELQRVGPAA CLCPGLSSPA QPPDPPRMGE VRIAAEEGRA VVHWCAPFSP VLHYWLLLWD
GSEAAQKGPP LNATVRRAEL KGLKPGGIYV VCVVAANEAG ASRVPQAGGE GLEGADIPAF
GPCSRLAVPP NPRTLVHAAV GVGTALALLS CAALVWHFCL RDRWGCPRRA AARAAGAL
