LRN4L_MOUSE
ID LRN4L_MOUSE Reviewed; 239 AA.
AC Q3TYX2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=LRRN4 C-terminal-like protein;
DE Flags: Precursor;
GN Name=Lrrn4cl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Inner ear;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK158268; BAE34439.1; -; mRNA.
DR EMBL; BC107244; AAI07245.1; -; mRNA.
DR EMBL; BC107245; AAI07246.1; -; mRNA.
DR CCDS; CCDS37909.1; -.
DR RefSeq; NP_001013037.1; NM_001013019.2.
DR RefSeq; XP_006527384.1; XM_006527321.2.
DR AlphaFoldDB; Q3TYX2; -.
DR SMR; Q3TYX2; -.
DR GlyGen; Q3TYX2; 2 sites.
DR PhosphoSitePlus; Q3TYX2; -.
DR PaxDb; Q3TYX2; -.
DR PRIDE; Q3TYX2; -.
DR ProteomicsDB; 252523; -.
DR Antibodypedia; 28669; 90 antibodies from 19 providers.
DR Ensembl; ENSMUST00000096257; ENSMUSP00000093976; ENSMUSG00000071656.
DR Ensembl; ENSMUST00000235683; ENSMUSP00000157980; ENSMUSG00000071656.
DR GeneID; 68852; -.
DR KEGG; mmu:68852; -.
DR UCSC; uc008gnm.1; mouse.
DR CTD; 221091; -.
DR MGI; MGI:1916102; Lrrn4cl.
DR VEuPathDB; HostDB:ENSMUSG00000071656; -.
DR eggNOG; ENOG502S4YI; Eukaryota.
DR GeneTree; ENSGT00940000162696; -.
DR HOGENOM; CLU_093350_0_0_1; -.
DR InParanoid; Q3TYX2; -.
DR OMA; SCSALVW; -.
DR OrthoDB; 1177486at2759; -.
DR PhylomeDB; Q3TYX2; -.
DR BioGRID-ORCS; 68852; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Lrrn4cl; mouse.
DR PRO; PR:Q3TYX2; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q3TYX2; protein.
DR Bgee; ENSMUSG00000071656; Expressed in tarsal region and 89 other tissues.
DR Genevisible; Q3TYX2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..239
FT /note="LRRN4 C-terminal-like protein"
FT /id="PRO_0000317753"
FT TOPO_DOM 20..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 82..179
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 174
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 239 AA; 25931 MW; 9E4E2C715F00BF86 CRC64;
MLGSLSLLWL AAMTTSLVSQ PQILTLEDYQ EGEEDDVTVA TPSLAVRCDY DRCRHLQVSC
QELQKVGPVA CLCPGLSRED QQPEPPRLGE VQIMAEEGYA VVHWCAPFSP VSHYWLLLWE
SNGAPQKSAP LNATVRRAEL KGLKPGVAYV LCVVAANDAG ESNVPGAEVE GPENWTGPSF
GPCRKFIMPP KPVTLVYAAV GVGTALALLS CAALVWHFCL RERWGCPRRQ GMAQASEAL
