LRP10_MOUSE
ID LRP10_MOUSE Reviewed; 713 AA.
AC Q7TQH7; Q3UNT0; Q7TS95; Q921T0; Q9EPE8;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Low-density lipoprotein receptor-related protein 10;
DE Short=LRP-10;
DE Flags: Precursor;
GN Name=Lrp10; Synonyms=Lrp9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Lymphocyte;
RX PubMed=11123907; DOI=10.1021/bi001583s;
RA Sugiyama T., Kumagai H., Morikawa Y., Wada Y., Sugiyama A., Yasuda K.,
RA Yokoi N., Tamura S., Kojima T., Nosaka T., Senba E., Kimura S.,
RA Kadowaki T., Kodama T., Kitamura T.;
RT "A novel low-density lipoprotein receptor-related protein mediating
RT cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro.";
RL Biochemistry 39:15817-15825(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable receptor, which is involved in the internalization
CC of lipophilic molecules and/or signal transduction. May be involved in
CC the uptake of lipoprotein APOE in liver. {ECO:0000269|PubMed:11123907}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}. Membrane, coated pit {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Highly expressed in heart, lung, liver and liver.
CC Expressed at low level in brain and spleen. Weakly or not expressed in
CC testis and skeletal muscle. In liver, it is expressed in hepatocytes
CC and at higher level in sinusoidal lining. In the kidney, it is
CC expressed in peritubular capillaries. In brain, it is expressed in the
CC epithelium of the choroid plexus ependymal cells of the third ventricle
CC pia matter, and to lesser extent in hippocampal fields CA2 and CA3.
CC {ECO:0000269|PubMed:11123907}.
CC -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH11058.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB042200; BAB20775.1; -; mRNA.
DR EMBL; AK144035; BAE25667.1; -; mRNA.
DR EMBL; BC011058; AAH11058.1; ALT_INIT; mRNA.
DR EMBL; BC052378; AAH52378.1; -; mRNA.
DR EMBL; BC054447; AAH54447.1; -; mRNA.
DR CCDS; CCDS27089.1; -.
DR RefSeq; NP_075369.2; NM_022993.3.
DR AlphaFoldDB; Q7TQH7; -.
DR SMR; Q7TQH7; -.
DR STRING; 10090.ENSMUSP00000022782; -.
DR GlyGen; Q7TQH7; 4 sites.
DR iPTMnet; Q7TQH7; -.
DR PhosphoSitePlus; Q7TQH7; -.
DR SwissPalm; Q7TQH7; -.
DR EPD; Q7TQH7; -.
DR MaxQB; Q7TQH7; -.
DR PaxDb; Q7TQH7; -.
DR PRIDE; Q7TQH7; -.
DR ProteomicsDB; 292044; -.
DR Antibodypedia; 95; 117 antibodies from 24 providers.
DR DNASU; 65107; -.
DR Ensembl; ENSMUST00000022782; ENSMUSP00000022782; ENSMUSG00000022175.
DR GeneID; 65107; -.
DR KEGG; mmu:65107; -.
DR UCSC; uc007twd.1; mouse.
DR CTD; 26020; -.
DR MGI; MGI:1929480; Lrp10.
DR VEuPathDB; HostDB:ENSMUSG00000022175; -.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000160783; -.
DR HOGENOM; CLU_013747_2_0_1; -.
DR InParanoid; Q7TQH7; -.
DR OMA; DWLMCLP; -.
DR OrthoDB; 135036at2759; -.
DR PhylomeDB; Q7TQH7; -.
DR TreeFam; TF332149; -.
DR Reactome; R-MMU-975634; Retinoid metabolism and transport.
DR BioGRID-ORCS; 65107; 8 hits in 77 CRISPR screens.
DR ChiTaRS; Lrp10; mouse.
DR PRO; PR:Q7TQH7; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q7TQH7; protein.
DR Bgee; ENSMUSG00000022175; Expressed in choroid plexus of fourth ventricle and 276 other tissues.
DR ExpressionAtlas; Q7TQH7; baseline and differential.
DR Genevisible; Q7TQH7; MM.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IDA:MGI.
DR GO; GO:0048839; P:inner ear development; IDA:MGI.
DR GO; GO:0006629; P:lipid metabolic process; IDA:MGI.
DR GO; GO:0006869; P:lipid transport; IDA:MGI.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 2.60.120.290; -; 2.
DR Gene3D; 4.10.400.10; -; 4.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 4.
DR SUPFAM; SSF49854; SSF49854; 2.
DR SUPFAM; SSF57424; SSF57424; 2.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 4.
PE 2: Evidence at transcript level;
KW Coated pit; Disulfide bond; Endocytosis; Glycoprotein; Membrane;
KW Phosphoprotein; Receptor; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..713
FT /note="Low-density lipoprotein receptor-related protein 10"
FT /id="PRO_0000017336"
FT TOPO_DOM 18..441
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 463..713
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 29..137
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 140..176
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 193..306
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 308..355
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 356..398
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 399..435
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT REGION 566..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 596
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z4F1"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 300
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..58
FT /evidence="ECO:0000250"
FT DISULFID 81..99
FT /evidence="ECO:0000250"
FT DISULFID 141..153
FT /evidence="ECO:0000250"
FT DISULFID 148..166
FT /evidence="ECO:0000250"
FT DISULFID 160..175
FT /evidence="ECO:0000250"
FT DISULFID 193..221
FT /evidence="ECO:0000250"
FT DISULFID 309..332
FT /evidence="ECO:0000250"
FT DISULFID 316..345
FT /evidence="ECO:0000250"
FT DISULFID 339..354
FT /evidence="ECO:0000250"
FT DISULFID 357..375
FT /evidence="ECO:0000250"
FT DISULFID 364..388
FT /evidence="ECO:0000250"
FT DISULFID 382..397
FT /evidence="ECO:0000250"
FT DISULFID 400..412
FT /evidence="ECO:0000250"
FT DISULFID 407..425
FT /evidence="ECO:0000250"
FT DISULFID 419..434
FT /evidence="ECO:0000250"
FT CONFLICT 554
FT /note="I -> V (in Ref. 1; BAB20775 and 3; AAH54447)"
FT /evidence="ECO:0000305"
FT CONFLICT 598
FT /note="Q -> H (in Ref. 1; BAB20775)"
FT /evidence="ECO:0000305"
FT CONFLICT 637
FT /note="P -> T (in Ref. 1; BAB20775)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 713 AA; 76461 MW; 27B2B2D44E9AB6E1 CRC64;
MLSALPLLFL LLGGALARPD RITFPRSACE APPAVLSEVQ GTLQRPLGRD SRSSPANCTW
VILGSKDQTV TVRFQKLHLA CGSEHLILHS PLQPPISLCE APSGPLQLPG GNVTITYSYA
GARAPMGQGF LLTYSQDWLL CLQEEFQCLN HRCIPAAQRC DGIDACGDGS DEAGCSSDPF
PNLNPAPAPT LACNLTLEDF YGVFSSPGYS HLASVSHPQS CLWLLDPHDG RRLAVRFTAL
DLSYGDAVHV YDGAGPPETP RLLRSLTHFS NGKAVTVETL SGQAVVSYHT VAWSSGRGFN
ATYHVRGYCL PWDRPCGLGS GLGASENLGE RCYSEAQRCD GSWDCADGTD EEGCPGCPPG
HFPCGAAGTP GATACYLPAD RCNYQTFCAD GADERRCRHC QPGNFRCRDE KCVYETWVCD
GQPDCTDGSD EWDCSYALPR KVITAAVIGS LVCGLLLVIA LGCTCKLYAI RTQEYSIFAP
LSRMEAEIVQ QQAPPSYGQL IAQGAIPPVE DFPTENPNDN SVLGNLRSLL QILRQDMTPG
GTSGGRRRQR GRSIRRLVRR LRRWGLLPRT NTPARAPETR SQVTPSVPSE ALDDSTGQAC
EGGAVGGQDG EQAPPLPIKT PIPTPSTLPA LATVSEPPGP LPSVPVESSL LSGVVQVLRG
RLLPSLWSPG PTWTQTGTHT TVLSPEDEDD VLLLPLAEPE VWVVEAEDEP LLA
