LRP11_HUMAN
ID LRP11_HUMAN Reviewed; 500 AA.
AC Q86VZ4; Q5VYC0; Q96SN6;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Low-density lipoprotein receptor-related protein 11;
DE Short=LRP-11;
DE Flags: Precursor;
GN Name=LRP11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP ARG-92 AND HIS-351.
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86VZ4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86VZ4-2; Sequence=VSP_017535, VSP_017536;
CC -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
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DR EMBL; AK027641; BAB55257.1; -; mRNA.
DR EMBL; AL355312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC025239; AAH25239.1; -; mRNA.
DR EMBL; BC043141; AAH43141.1; -; mRNA.
DR CCDS; CCDS5220.1; -. [Q86VZ4-1]
DR RefSeq; NP_116221.3; NM_032832.5. [Q86VZ4-1]
DR AlphaFoldDB; Q86VZ4; -.
DR BioGRID; 124354; 39.
DR IntAct; Q86VZ4; 16.
DR STRING; 9606.ENSP00000239367; -.
DR GlyGen; Q86VZ4; 4 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q86VZ4; -.
DR PhosphoSitePlus; Q86VZ4; -.
DR BioMuta; LRP11; -.
DR DMDM; 92058704; -.
DR EPD; Q86VZ4; -.
DR jPOST; Q86VZ4; -.
DR MassIVE; Q86VZ4; -.
DR MaxQB; Q86VZ4; -.
DR PaxDb; Q86VZ4; -.
DR PeptideAtlas; Q86VZ4; -.
DR PRIDE; Q86VZ4; -.
DR ProteomicsDB; 70094; -. [Q86VZ4-1]
DR ProteomicsDB; 70095; -. [Q86VZ4-2]
DR TopDownProteomics; Q86VZ4-1; -. [Q86VZ4-1]
DR Antibodypedia; 33293; 86 antibodies from 25 providers.
DR DNASU; 84918; -.
DR Ensembl; ENST00000239367.7; ENSP00000239367.2; ENSG00000120256.11. [Q86VZ4-1]
DR GeneID; 84918; -.
DR KEGG; hsa:84918; -.
DR MANE-Select; ENST00000239367.7; ENSP00000239367.2; NM_032832.6; NP_116221.3.
DR UCSC; uc003qng.3; human. [Q86VZ4-1]
DR CTD; 84918; -.
DR DisGeNET; 84918; -.
DR GeneCards; LRP11; -.
DR HGNC; HGNC:16936; LRP11.
DR HPA; ENSG00000120256; Low tissue specificity.
DR neXtProt; NX_Q86VZ4; -.
DR OpenTargets; ENSG00000120256; -.
DR PharmGKB; PA134880462; -.
DR VEuPathDB; HostDB:ENSG00000120256; -.
DR eggNOG; ENOG502QW7V; Eukaryota.
DR GeneTree; ENSGT00940000161275; -.
DR HOGENOM; CLU_042674_1_0_1; -.
DR InParanoid; Q86VZ4; -.
DR OMA; AINMKST; -.
DR PhylomeDB; Q86VZ4; -.
DR TreeFam; TF325867; -.
DR PathwayCommons; Q86VZ4; -.
DR SignaLink; Q86VZ4; -.
DR BioGRID-ORCS; 84918; 9 hits in 1084 CRISPR screens.
DR ChiTaRS; LRP11; human.
DR GenomeRNAi; 84918; -.
DR Pharos; Q86VZ4; Tdark.
DR PRO; PR:Q86VZ4; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q86VZ4; protein.
DR Bgee; ENSG00000120256; Expressed in islet of Langerhans and 99 other tissues.
DR ExpressionAtlas; Q86VZ4; baseline and differential.
DR Genevisible; Q86VZ4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IC:AgBase.
DR GO; GO:0051219; F:phosphoprotein binding; IMP:AgBase.
DR GO; GO:0033555; P:multicellular organismal response to stress; IEA:Ensembl.
DR GO; GO:0009409; P:response to cold; IEA:Ensembl.
DR GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR GO; GO:0035902; P:response to immobilization stress; IEA:Ensembl.
DR GO; GO:0009612; P:response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0042594; P:response to starvation; IEA:Ensembl.
DR GO; GO:0009414; P:response to water deprivation; IEA:Ensembl.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 4.10.400.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR042484; LRP11.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR46876; PTHR46876; 2.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF07502; MANEC; 1.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00765; MANEC; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; SSF49299; 1.
DR SUPFAM; SSF57424; SSF57424; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50986; MANSC; 1.
DR PROSITE; PS50093; PKD; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Membrane;
KW Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..37
FT /evidence="ECO:0000255"
FT CHAIN 38..500
FT /note="Low-density lipoprotein receptor-related protein 11"
FT /id="PRO_0000017337"
FT TOPO_DOM 38..450
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 474..500
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 99..184
FT /note="MANSC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00341"
FT DOMAIN 210..305
FT /note="PKD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00151"
FT DOMAIN 309..345
FT /note="LDL-receptor class A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT REGION 358..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 491
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8CB67"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 291
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 401
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 310..322
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 317..335
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 329..344
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT VAR_SEQ 205..237
FT /note="EKDAPPLSKAGQDVVLHLPTDGVVLDGRESTDD -> GKRATEGPALARALE
FT TRSALAKLEAKHTRAKLF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017535"
FT VAR_SEQ 238..500
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017536"
FT VARIANT 92
FT /note="P -> R (in dbSNP:rs9322225)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_025537"
FT VARIANT 281
FT /note="T -> M (in dbSNP:rs9478945)"
FT /id="VAR_056002"
FT VARIANT 351
FT /note="R -> H (in dbSNP:rs17854254)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_025538"
FT VARIANT 442
FT /note="G -> R (in dbSNP:rs9478144)"
FT /id="VAR_056003"
SQ SEQUENCE 500 AA; 53311 MW; A90C62D2154C9C31 CRC64;
MASVAQESAG SQRRLPPRHG ALRGLLLLCL WLPSGRAALP PAAPLSELHA QLSGVEQLLE
EFRRQLQQER PQEELELELR AGGGPQEDCP GPGSGGYSAM PDAIIRTKDS LAAGASFLRA
PAAVRGWRQC VAACCSEPRC SVAVVELPRR PAPPAAVLGC YLFNCTARGR NVCKFALHSG
YSSYSLSRAP DGAALATARA SPRQEKDAPP LSKAGQDVVL HLPTDGVVLD GRESTDDHAI
VQYEWALLQG DPSVDMKVPQ SGTLKLSHLQ EGTYTFQLTV TDTAGQRSSD NVSVTVLRAA
YSTGGCLHTC SRYHFFCDDG CCIDITLACD GVQQCPDGSD EDFCQNLGLD RKMVTHTAAS
PALPRTTGPS EDAGGDSLVE KSQKATAPNK PPALSNTEKR NHSAFWGPES QIIPVMPDSS
SSGKNRKEES YIFESKGDGG GGEHPAPETG AVLPLALGLA ITALLLLMVA CRLRLVKQKL
KKARPITSEE SDYLINGMYL
