LRP1B_MOUSE
ID LRP1B_MOUSE Reviewed; 4599 AA.
AC Q9JI18; Q8BZD3; Q8BZM7;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 29-SEP-2021, entry version 151.
DE RecName: Full=Low-density lipoprotein receptor-related protein 1B;
DE Short=LRP-1B;
DE AltName: Full=Low-density lipoprotein receptor-related protein-deleted in tumor;
DE Short=LRP-DIT;
DE Flags: Precursor;
GN Name=Lrp1b; Synonyms=Lrpdit;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yaklichkin S., Lisitsyn N.;
RT "The structure of the mouse homologue of the human candidate tumor
RT suppressor gene LRP1B/LRP-DIT.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3770-4599.
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Potential cell surface proteins that bind and internalize
CC ligands in the process of receptor-mediated endocytosis.
CC -!- SUBUNIT: Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by
CC internalization and degradation of the ligands. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9JI18; Q9WVI9-1: Mapk8ip1; NbExp=3; IntAct=EBI-8294317, EBI-288461;
CC Q9JI18; Q80VC8: Pick1; NbExp=4; IntAct=EBI-8294317, EBI-8521477;
CC Q9JI18; P69566: Ranbp9; NbExp=2; IntAct=EBI-8294317, EBI-772305;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
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DR EMBL; AF270884; AAF81758.1; -; mRNA.
DR EMBL; AK035795; BAC29188.1; -; mRNA.
DR EMBL; AK034122; BAC28594.1; -; mRNA.
DR CCDS; CCDS84520.1; -.
DR SMR; Q9JI18; -.
DR IntAct; Q9JI18; 7.
DR MINT; Q9JI18; -.
DR STRING; 10090.ENSMUSP00000054275; -.
DR GlyConnect; 2484; 12 N-Linked glycans (13 sites).
DR GlyGen; Q9JI18; 46 sites, 12 N-linked glycans (13 sites).
DR iPTMnet; Q9JI18; -.
DR PhosphoSitePlus; Q9JI18; -.
DR PaxDb; Q9JI18; -.
DR PRIDE; Q9JI18; -.
DR ProteomicsDB; 252524; -.
DR MGI; MGI:2151136; Lrp1b.
DR eggNOG; KOG1215; Eukaryota.
DR InParanoid; Q9JI18; -.
DR ChiTaRS; Lrp1b; mouse.
DR PRO; PR:Q9JI18; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9JI18; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; ISO:MGI.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IDA:MGI.
DR GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR CDD; cd00112; LDLa; 30.
DR Gene3D; 2.120.10.30; -; 8.
DR Gene3D; 4.10.400.10; -; 32.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR032485; DUF5050.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF16472; DUF5050; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF00057; Ldl_recept_a; 31.
DR Pfam; PF00058; Ldl_recept_b; 10.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 24.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00192; LDLa; 32.
DR SMART; SM00135; LY; 36.
DR SUPFAM; SSF57184; SSF57184; 3.
DR SUPFAM; SSF57424; SSF57424; 32.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS01209; LDLRA_1; 27.
DR PROSITE; PS50068; LDLRA_2; 32.
DR PROSITE; PS51120; LDLRB; 36.
PE 1: Evidence at protein level;
KW Calcium; Disulfide bond; EGF-like domain; Endocytosis; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..4599
FT /note="Low-density lipoprotein receptor-related protein 1B"
FT /id="PRO_0000017320"
FT TOPO_DOM 21..4444
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 4445..4467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 4468..4599
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..70
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 76..114
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 116..154
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 155..194
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 295..337
FT /note="LDL-receptor class B 1"
FT REPEAT 338..381
FT /note="LDL-receptor class B 2"
FT REPEAT 382..425
FT /note="LDL-receptor class B 3"
FT DOMAIN 471..517
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 568..610
FT /note="LDL-receptor class B 4"
FT REPEAT 611..656
FT /note="LDL-receptor class B 5"
FT REPEAT 657..706
FT /note="LDL-receptor class B 6"
FT REPEAT 707..750
FT /note="LDL-receptor class B 7"
FT DOMAIN 794..834
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 844..882
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 885..923
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 926..963
FT /note="LDL-receptor class A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 966..1003
FT /note="LDL-receptor class A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1005..1043
FT /note="LDL-receptor class A 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1052..1089
FT /note="LDL-receptor class A 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1094..1132
FT /note="LDL-receptor class A 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1135..1174
FT /note="LDL-receptor class A 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1174..1213
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1214..1253
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 1300..1346
FT /note="LDL-receptor class B 8"
FT REPEAT 1347..1389
FT /note="LDL-receptor class B 9"
FT REPEAT 1390..1436
FT /note="LDL-receptor class B 10"
FT REPEAT 1437..1480
FT /note="LDL-receptor class B 11"
FT REPEAT 1481..1522
FT /note="LDL-receptor class B 12"
FT DOMAIN 1527..1570
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 1618..1660
FT /note="LDL-receptor class B 13"
FT REPEAT 1661..1704
FT /note="LDL-receptor class B 14"
FT REPEAT 1705..1744
FT /note="LDL-receptor class B 15"
FT REPEAT 1745..1787
FT /note="LDL-receptor class B 16"
FT DOMAIN 1834..1875
FT /note="EGF-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 1922..1964
FT /note="LDL-receptor class B 17"
FT REPEAT 1965..2007
FT /note="LDL-receptor class B 28"
FT REPEAT 2008..2051
FT /note="LDL-receptor class B 19"
FT REPEAT 2052..2095
FT /note="LDL-receptor class B 20"
FT DOMAIN 2143..2183
FT /note="EGF-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 2239..2280
FT /note="LDL-receptor class B 21"
FT REPEAT 2281..2329
FT /note="LDL-receptor class B 22"
FT REPEAT 2330..2374
FT /note="LDL-receptor class B 23"
FT REPEAT 2375..2416
FT /note="LDL-receptor class B 24"
FT REPEAT 2417..2459
FT /note="LDL-receptor class B 25"
FT DOMAIN 2464..2504
FT /note="EGF-like 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2509..2548
FT /note="LDL-receptor class A 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2551..2587
FT /note="LDL-receptor class A 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2590..2626
FT /note="LDL-receptor class A 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2629..2675
FT /note="LDL-receptor class A 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2681..2717
FT /note="LDL-receptor class A 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2719..2757
FT /note="LDL-receptor class A 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2760..2800
FT /note="LDL-receptor class A 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2804..2841
FT /note="LDL-receptor class A 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2844..2885
FT /note="LDL-receptor class A 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2890..2926
FT /note="LDL-receptor class A 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2927..2967
FT /note="EGF-like 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2968..3008
FT /note="EGF-like 12; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 3055..3098
FT /note="LDL-receptor class B 26"
FT REPEAT 3099..3141
FT /note="LDL-receptor class B 27"
FT REPEAT 3142..3185
FT /note="LDL-receptor class B 28"
FT REPEAT 3186..3224
FT /note="LDL-receptor class B 29"
FT REPEAT 3225..3268
FT /note="LDL-receptor class B 30"
FT DOMAIN 3273..3314
FT /note="EGF-like 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3316..3353
FT /note="LDL-receptor class A 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3356..3392
FT /note="LDL-receptor class A 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3395..3432
FT /note="LDL-receptor class A 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3435..3472
FT /note="LDL-receptor class A 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3475..3511
FT /note="LDL-receptor class A 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3514..3550
FT /note="LDL-receptor class A 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3552..3588
FT /note="LDL-receptor class A 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3593..3629
FT /note="LDL-receptor class A 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3631..3668
FT /note="LDL-receptor class A 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3673..3711
FT /note="LDL-receptor class A 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3714..3752
FT /note="LDL-receptor class A 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3761..3797
FT /note="LDL-receptor class A 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3801..3843
FT /note="EGF-like 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3844..3881
FT /note="EGF-like 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 3933..3980
FT /note="LDL-receptor class B 31"
FT REPEAT 3981..4038
FT /note="LDL-receptor class B 32"
FT REPEAT 4039..4082
FT /note="LDL-receptor class B 33"
FT REPEAT 4083..4127
FT /note="LDL-receptor class B 34"
FT DOMAIN 4171..4208
FT /note="EGF-like 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4213..4249
FT /note="EGF-like 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4249..4285
FT /note="EGF-like 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4285..4321
FT /note="EGF-like 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4321..4357
FT /note="EGF-like 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4357..4392
FT /note="EGF-like 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4390..4427
FT /note="EGF-like 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT MOTIF 4492..4495
FT /note="Endocytosis signal"
FT /evidence="ECO:0000255"
FT MOTIF 4559..4562
FT /note="Endocytosis signal"
FT /evidence="ECO:0000255"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 313
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 360
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 443
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 725
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 758
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 829
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 883
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 919
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1041
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1089
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1209
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1298
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1502
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1549
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1636
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1754
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1816
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1921
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1983
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2458
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2488
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2507
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2549
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2626
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2647
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2802
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2892
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3034
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3066
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3076
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3316
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3682
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3877
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3894
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3906
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4017
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4381
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4420
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..45
FT /evidence="ECO:0000250"
FT DISULFID 39..58
FT /evidence="ECO:0000250"
FT DISULFID 52..69
FT /evidence="ECO:0000250"
FT DISULFID 77..90
FT /evidence="ECO:0000250"
FT DISULFID 84..103
FT /evidence="ECO:0000250"
FT DISULFID 97..113
FT /evidence="ECO:0000250"
FT DISULFID 159..169
FT /evidence="ECO:0000250"
FT DISULFID 165..178
FT /evidence="ECO:0000250"
FT DISULFID 180..193
FT /evidence="ECO:0000250"
FT DISULFID 798..809
FT /evidence="ECO:0000250"
FT DISULFID 805..818
FT /evidence="ECO:0000250"
FT DISULFID 820..833
FT /evidence="ECO:0000250"
FT DISULFID 845..857
FT /evidence="ECO:0000250"
FT DISULFID 852..870
FT /evidence="ECO:0000250"
FT DISULFID 864..881
FT /evidence="ECO:0000250"
FT DISULFID 886..898
FT /evidence="ECO:0000250"
FT DISULFID 893..911
FT /evidence="ECO:0000250"
FT DISULFID 905..922
FT /evidence="ECO:0000250"
FT DISULFID 927..939
FT /evidence="ECO:0000250"
FT DISULFID 934..952
FT /evidence="ECO:0000250"
FT DISULFID 946..962
FT /evidence="ECO:0000250"
FT DISULFID 967..980
FT /evidence="ECO:0000250"
FT DISULFID 975..993
FT /evidence="ECO:0000250"
FT DISULFID 987..1002
FT /evidence="ECO:0000250"
FT DISULFID 1006..1018
FT /evidence="ECO:0000250"
FT DISULFID 1013..1031
FT /evidence="ECO:0000250"
FT DISULFID 1025..1042
FT /evidence="ECO:0000250"
FT DISULFID 1053..1066
FT /evidence="ECO:0000250"
FT DISULFID 1060..1079
FT /evidence="ECO:0000250"
FT DISULFID 1073..1088
FT /evidence="ECO:0000250"
FT DISULFID 1095..1109
FT /evidence="ECO:0000250"
FT DISULFID 1103..1122
FT /evidence="ECO:0000250"
FT DISULFID 1116..1131
FT /evidence="ECO:0000250"
FT DISULFID 1136..1150
FT /evidence="ECO:0000250"
FT DISULFID 1143..1163
FT /evidence="ECO:0000250"
FT DISULFID 1157..1173
FT /evidence="ECO:0000250"
FT DISULFID 1176..1187
FT /evidence="ECO:0000250"
FT DISULFID 1183..1197
FT /evidence="ECO:0000250"
FT DISULFID 1199..1212
FT /evidence="ECO:0000250"
FT DISULFID 1531..1544
FT /evidence="ECO:0000250"
FT DISULFID 1540..1554
FT /evidence="ECO:0000250"
FT DISULFID 1556..1569
FT /evidence="ECO:0000250"
FT DISULFID 1838..1849
FT /evidence="ECO:0000250"
FT DISULFID 1845..1859
FT /evidence="ECO:0000250"
FT DISULFID 1861..1874
FT /evidence="ECO:0000250"
FT DISULFID 2147..2158
FT /evidence="ECO:0000250"
FT DISULFID 2154..2168
FT /evidence="ECO:0000250"
FT DISULFID 2170..2182
FT /evidence="ECO:0000250"
FT DISULFID 2510..2523
FT /evidence="ECO:0000250"
FT DISULFID 2518..2536
FT /evidence="ECO:0000250"
FT DISULFID 2530..2547
FT /evidence="ECO:0000250"
FT DISULFID 2552..2564
FT /evidence="ECO:0000250"
FT DISULFID 2559..2577
FT /evidence="ECO:0000250"
FT DISULFID 2571..2586
FT /evidence="ECO:0000250"
FT DISULFID 2591..2603
FT /evidence="ECO:0000250"
FT DISULFID 2598..2616
FT /evidence="ECO:0000250"
FT DISULFID 2610..2625
FT /evidence="ECO:0000250"
FT DISULFID 2630..2652
FT /evidence="ECO:0000250"
FT DISULFID 2646..2665
FT /evidence="ECO:0000250"
FT DISULFID 2659..2674
FT /evidence="ECO:0000250"
FT DISULFID 2682..2694
FT /evidence="ECO:0000250"
FT DISULFID 2689..2707
FT /evidence="ECO:0000250"
FT DISULFID 2701..2716
FT /evidence="ECO:0000250"
FT DISULFID 2720..2732
FT /evidence="ECO:0000250"
FT DISULFID 2727..2745
FT /evidence="ECO:0000250"
FT DISULFID 2739..2756
FT /evidence="ECO:0000250"
FT DISULFID 2761..2774
FT /evidence="ECO:0000250"
FT DISULFID 2768..2787
FT /evidence="ECO:0000250"
FT DISULFID 2781..2799
FT /evidence="ECO:0000250"
FT DISULFID 2805..2817
FT /evidence="ECO:0000250"
FT DISULFID 2812..2830
FT /evidence="ECO:0000250"
FT DISULFID 2824..2840
FT /evidence="ECO:0000250"
FT DISULFID 2845..2857
FT /evidence="ECO:0000250"
FT DISULFID 2852..2871
FT /evidence="ECO:0000250"
FT DISULFID 2865..2884
FT /evidence="ECO:0000250"
FT DISULFID 2891..2903
FT /evidence="ECO:0000250"
FT DISULFID 2898..2916
FT /evidence="ECO:0000250"
FT DISULFID 2910..2925
FT /evidence="ECO:0000250"
FT DISULFID 2930..2942
FT /evidence="ECO:0000250"
FT DISULFID 2938..2951
FT /evidence="ECO:0000250"
FT DISULFID 2953..2966
FT /evidence="ECO:0000250"
FT DISULFID 2972..2982
FT /evidence="ECO:0000250"
FT DISULFID 2978..2991
FT /evidence="ECO:0000250"
FT DISULFID 2993..3007
FT /evidence="ECO:0000250"
FT DISULFID 3317..3329
FT /evidence="ECO:0000250"
FT DISULFID 3324..3342
FT /evidence="ECO:0000250"
FT DISULFID 3336..3352
FT /evidence="ECO:0000250"
FT DISULFID 3357..3369
FT /evidence="ECO:0000250"
FT DISULFID 3364..3382
FT /evidence="ECO:0000250"
FT DISULFID 3376..3391
FT /evidence="ECO:0000250"
FT DISULFID 3396..3409
FT /evidence="ECO:0000250"
FT DISULFID 3403..3422
FT /evidence="ECO:0000250"
FT DISULFID 3416..3431
FT /evidence="ECO:0000250"
FT DISULFID 3436..3449
FT /evidence="ECO:0000250"
FT DISULFID 3443..3462
FT /evidence="ECO:0000250"
FT DISULFID 3456..3471
FT /evidence="ECO:0000250"
FT DISULFID 3476..3488
FT /evidence="ECO:0000250"
FT DISULFID 3483..3501
FT /evidence="ECO:0000250"
FT DISULFID 3495..3510
FT /evidence="ECO:0000250"
FT DISULFID 3515..3527
FT /evidence="ECO:0000250"
FT DISULFID 3522..3540
FT /evidence="ECO:0000250"
FT DISULFID 3534..3549
FT /evidence="ECO:0000250"
FT DISULFID 3553..3565
FT /evidence="ECO:0000250"
FT DISULFID 3560..3578
FT /evidence="ECO:0000250"
FT DISULFID 3572..3587
FT /evidence="ECO:0000250"
FT DISULFID 3594..3606
FT /evidence="ECO:0000250"
FT DISULFID 3601..3619
FT /evidence="ECO:0000250"
FT DISULFID 3613..3628
FT /evidence="ECO:0000250"
FT DISULFID 3632..3645
FT /evidence="ECO:0000250"
FT DISULFID 3639..3658
FT /evidence="ECO:0000250"
FT DISULFID 3652..3667
FT /evidence="ECO:0000250"
FT DISULFID 3674..3686
FT /evidence="ECO:0000250"
FT DISULFID 3681..3699
FT /evidence="ECO:0000250"
FT DISULFID 3693..3710
FT /evidence="ECO:0000250"
FT DISULFID 3715..3729
FT /evidence="ECO:0000250"
FT DISULFID 3723..3742
FT /evidence="ECO:0000250"
FT DISULFID 3736..3751
FT /evidence="ECO:0000250"
FT DISULFID 3762..3774
FT /evidence="ECO:0000250"
FT DISULFID 3769..3787
FT /evidence="ECO:0000250"
FT DISULFID 3781..3796
FT /evidence="ECO:0000250"
FT DISULFID 3805..3818
FT /evidence="ECO:0000250"
FT DISULFID 3812..3827
FT /evidence="ECO:0000250"
FT DISULFID 3829..3842
FT /evidence="ECO:0000250"
FT DISULFID 3848..3858
FT /evidence="ECO:0000250"
FT DISULFID 3854..3867
FT /evidence="ECO:0000250"
FT DISULFID 4217..4227
FT /evidence="ECO:0000250"
FT DISULFID 4221..4237
FT /evidence="ECO:0000250"
FT DISULFID 4239..4248
FT /evidence="ECO:0000250"
FT DISULFID 4253..4263
FT /evidence="ECO:0000250"
FT DISULFID 4257..4273
FT /evidence="ECO:0000250"
FT DISULFID 4275..4284
FT /evidence="ECO:0000250"
FT DISULFID 4289..4299
FT /evidence="ECO:0000250"
FT DISULFID 4293..4309
FT /evidence="ECO:0000250"
FT DISULFID 4311..4320
FT /evidence="ECO:0000250"
FT DISULFID 4325..4335
FT /evidence="ECO:0000250"
FT DISULFID 4329..4345
FT /evidence="ECO:0000250"
FT DISULFID 4347..4356
FT /evidence="ECO:0000250"
FT DISULFID 4394..4404
FT /evidence="ECO:0000250"
FT DISULFID 4398..4415
FT /evidence="ECO:0000250"
FT DISULFID 4417..4426
FT /evidence="ECO:0000250"
FT CONFLICT 4521..4553
FT /note="Missing (in Ref. 2; BAC29188)"
FT /evidence="ECO:0000305"
FT CONFLICT 4552
FT /note="F -> S (in Ref. 2; BAC28594)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 4599 AA; 513634 MW; 11462A3354FFB200 CRC64;
MSQLLLAILT LSGLLPNAEV LIVGANQDQH LCDPGEFLCH DHVTCVSQSW LCDGDPDCPD
QSDESLDTCP EEVEIKCPLN HIACHGSSAC VHLSKLCNGV VDCPDGFDEG GHCQELLPSC
QQLNCQFKCA MVRNATRCYC EDGFEVAEDG RSCKDQDECS IYGICSQTCK NTYGSYACSC
VEGYIMQSDN RSCKVKHEPT DKAPMLLISS LETIELFYIN GSKMTTLSSA NRNEIHTLDF
IYSEEMICWI ESRESSNQLK CGQITKAGRL TDQRIINSLQ SFQNVEQMAF DWLTRNIYFV
DHVSDRIFVC NFNGSVCVTL IESELHNPKA IAADPIAGKL FFTDYGNVPK IERCDLDGMN
RTRIVYSKAE QPSALALDLV NRLVYWVDLY LDYVGVVDYQ GKNRHTIVQG RQVKHLYGIT
VFEDYLYATS SDNFNIIRIN RFNGTDIHSI IKMESARGIR TYQKRTQPTV RSHACEVDAY
GMPGGCSHIC LLSSSYKTRT CRCRTGFNMG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL
NTKIADECMI PIENLVNPRA LDFHAEANYI YFADTTSFLI GRQKIDGTER ETILKDDLDN
VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGGMSHPRAI VVDPVNGWMY
WTDWKEDKID DSVGRIEKAW MDGVNRQVFV TSKMLWPNGL TLDFHTSTLY WCDAYYDHIE
KVFLNGTHRK VVYSGKELNH PFGLSHHGNY VFWTDYMNGS IFQLDLMTNE VTLLRHERAP
LFGLQIYDPR KQQGDNMCRI NNGGCGTLCL AIPAGRVCAC ADNQLLDENG TTCTFNPEEI
RFHICKPGEF RCKNKHCIQA RWKCDGDDDC LDGSDEDSVT CFNHSCPDDQ FKCQNNRCIP
KRWLCDGAND CGSNEDESNQ TCTARTCQAD QFSCGNGRCI PTAWLCDRED DCGDQTDEVA
SCEFPTCEPL TQFICKSGRC ISNKWHCDTD DDCGDRSDEV GCVHSCLDDQ FRCSSGRCIP
GHWACDGDND CGDFSDETHI NCTKEEARSP AGCIGNEFQC RPDGNCIPDL WRCDGEKDCE
DGSDEKGCNG TIRLCDHKTK FSCRSTGRCI NNAWVCDGDV DCEDQSDEED CDSFLCGPPK
YPCANDTSVC LQPEKLCNGR KDCPDGSDEG DLCDECSLNN GGCSNHCSVV PGRGIVCSCP
EGHQLKKDNR TCEIVDYCAS HLRCSQVCEQ QKHMVKCSCY EGWALGTDGE SCTSVDSFEA
FIIFSIRHEI RRIDLHKGDY SLLVPGLRNT IALDFHFNQS LLYWTDVVED RIYRGKLSES
GGVSAIEVVV EHGLATPEGL TVDWIAGNIY WIDSNLDQIE VSKLDGSLRA TLIAGAMEHP
RAIALDPRYG ILFWTDWDAN FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFERRIV
WTDARSDAIY SAFYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLAKANKWTG
QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANEGRGPC SHLCLINHNR SAACACPHLM
KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYVNFITAF TVPDIDDVAV IDFDASEERL
YWTDIKTQTI TRAFINGTGL ETVISRDIQS IRGLAVDWVS RNLYWISSEF DETQINVARL
DGSLKTSIIH GIDKPQCLAA HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI
DYVENKLYWI SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL
GTCNKRDGRN PSILRNKTSG VVHMKVYDKE AQQGSNSCQV NNGGCSQLCL PTSETTRTCM
CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPRDKV DALMPISGAA FAVGIDFHAE
NDTIYWTDMG LNKISRAKRD QTWKEDVVTN GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA
RLNGSFRYVI ISQGLDQPRS IAVHPEKGFL FWTEWGQVPC IGKARLDGSE KVMIVSVGIT
WPNGISIDYE ENKLYWCDAR SDKIERIDLD TGANREVLLS GSNVDLFSVA VFGAYIYWSD
RAHANGSVRR GHKNDATETV TMRTGLGVNL KEIKIFNRVR EKGTNVCAKE NGGCQQLCLY
RGNSRRTCAC AHGYLAGDGV TCLRHEGYLL YSGRTILKSI HLSDETNLNS PVRPYENPNY
FKNIIALAFD YNQRREGTNR IFYSDAHFGN IQLIKDNWED RQVIVENVGS VEGLAYHRAW
DTLYWTSSST SSITRHTVDQ TRPGAIDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ
HPSIMRATLT GKNAHVVVST DILTPNGLTI DHRAEKLYFS DGSLGKIERC EYDGSQRHVI
VKSGPGTFLS LAVYDSYIFW SDWGRRAILR SNKYTGGETK ILRSDIPHQP MGIIAVANDT
NSCELSPCAL LNGGCHDLCL LTPDGRVNCS CRGDRVLLAN NRCVTKNSSC NIYSEFECGN
GDCVDYVLTC DGIPHCKDKS DEKLLYCENR SCRSGFKPCY NRRCVPHGKL CDGTNDCGDS
SDELDCKVST CSTVEFRCAD GTCIPRSARC NQNMDCSDAS DEKGCNNTDC THFYKLGVKS
TGFIRCNSTS LCVLPSWICD GSNDCGDYSD ELKCPVQNKH KCEENYFGCP SGRCILNTWV
CDGQKDCEDG LDELHCDSSC SWNQFACSVK KCISKHWICD GEDDCGDSLD ESDSICGAVT
CAADMFSCQG SHACVPQHWL CDGERDCPDG SDELSSAGCA PNNTCDENAF MCHNKVCIPK
QFVCDHDDDC GDGSDEFLQC GYRQCGPEEF RCADGRCLVN TLWQCDGDFD CPDSSDEAPI
NPRCRSAEHS CNSSFFMCKN GRCIPSDGLC DIRDDCGDGS DETNCHINEC LSKKISGCSQ
DCQDLPVSYK CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CHCAEGYETQ
PDNPNGCRSL SDEEPFLILA DQHEIRKIST DGSNYTLLKQ GLNNVIALDF DYREEFIYWI
DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN LYWSDTEKRI IEVSKLNGLY
PTVLVSKRLK FPRDLSLDPR AGNLYWIDCC EYPHIGRVGM DGTNQSVVIE TKISRPMALT
IDYVNHRLYW ADENHIEFSN MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRV
HKTSGADRLS LINSWHAITD IQVYHSYRQP DVSKHLCTVN NGGCSHLCLL GPGKTHTCAC
PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD DCPEFKCQPG
RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLAGQ FKCTKNKKCI PVNLRCNGQD
DCGDEEDEKD CPENSCSPDY FQCKTTKHCI SKLWVCDEDP DCADASDEAN CDKKTCGPHE
FQCKNNNCIP DHWRCDNQND CSDNSDEDNC KPQTCTLKDF LCSNGDCVSS RFWCDGEFDC
ADGSDEKNCE TSCSKDQFQC SNGQCLSAKW KCDGHEDCKY GEDEKNCEPA FPVCSSSEYM
CASGGCLSAS LKCNGEPDCV DGSDEMDCVI ECKEDQFQCK NKAYCIPIRW LCDGIYDCVD
GSDEETCGRG GSICRDDEFL CNNSLCKLHF WVCDGEDDCG DNSDEAPDMC VKFLCPPTRP
YRCRNDRICL QLEKICNGIN DCGDNSDEEH CSGKLSLKSK PCKKDEFTCS NRNCIPMELQ
CDSLDDCGDG SDEQGCLKTP IEHTCENNGN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKGR
ECADLNECLL FGICSHHCLN TRGSYKCVCD QNFQEKNNSC IAKGSEDQAL YIANDTDILG
FVYPFNYSGG HQQISHVEHN SRITGMDVHY QRNVIVWSTQ FNPGGIFYKM IDAREKRQAN
SGLICPEFKR PRDIAVDWVA GNVYWTDHSR MHWFSYYTTH WTSLRYSINV GQLNGPNCTR
LLTNMAGEPY AIAVNPKRGM MYWTVIGDHS HIEEAAMDGT LRRVLVQKNL QRPTGLTVDH
FGERIYWADF ELSIIGSVLY DGSSPVVSVS SKQGLLHPHR IDVFEDYIYG AGPKNGIFRV
QKFGHGSVEV LALGVDKTKS ILVSHRYKQL NLPNPCLDLS CDFLCLLNPS GATCICPEGK
YMMNGTCHDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGGRCEV NHCSNYCQNG
GTCIPSTLGR PTCICALGFT GPNCGKAVCE DSCHNGGSCV VTAGNQPYCH CQADYTGDRC
QYYVCHHYCV NSESCTIGND GSVECVCPTR YEGPKCEIDK CVRCHGGHCI INKDNEDIFC
NCTNGKIASS CQLCDGYCYN GGTCQLDPET SIPVCVCSTN WSGTQCERPA PKSSKSEHIS
TRSIAIIVPL VLLVTLVTTL VIGLVVCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV
DHDHSDGGLL EPSFMIDPVK SRYIGGGSSA FKLPHTAPPI YLNSDLKGPL TFGPTNYSNP
VYAKLYMDGQ NCRNSLASVD ERKELLPKKI EIGIRETVA
