LRP1_CHICK
ID LRP1_CHICK Reviewed; 4543 AA.
AC P98157;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Low-density lipoprotein receptor-related protein 1;
DE Short=LRP-1;
DE AltName: Full=Alpha-2-macroglobulin receptor;
DE Short=A2MR;
DE Flags: Precursor;
GN Name=LRP1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=White leghorn; TISSUE=Liver, and Ovary;
RX PubMed=7506255; DOI=10.1016/s0021-9258(17)42336-2;
RA Nimpf J., Stifani S., Bilous P.T., Schneider W.J.;
RT "The somatic cell-specific low density lipoprotein receptor-related protein
RT of the chicken. Close kinship to mammalian low density lipoprotein receptor
RT gene family members.";
RL J. Biol. Chem. 269:212-219(1994).
RN [2]
RP 3D-STRUCTURE MODELING.
RX PubMed=9790844; DOI=10.1006/jmbi.1998.2115;
RA Springer T.A.;
RT "An extracellular beta-propeller module predicted in lipoprotein and
RT scavenger receptors, tyrosine kinases, epidermal growth factor precursor,
RT and extracellular matrix components.";
RL J. Mol. Biol. 283:837-862(1998).
CC -!- FUNCTION: Endocytic receptor involved in endocytosis and in
CC phagocytosis of apoptotic cells. Involved in cellular lipid
CC homeostasis. Involved in the plasma clearance of chylomicron remnants
CC and activated LRPAP1 (alpha 2-macroglobulin), as well as the local
CC metabolism of complexes between plasminogen activators and their
CC endogenous inhibitors. Acts as an alpha-2-macroglobulin receptor.
CC {ECO:0000250|UniProtKB:Q07954}.
CC -!- SUBUNIT: Binds vitellogenin and LRPAP1 (alpha 2-macroglobulin).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC Membrane, coated pit.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P98157-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P98157-2; Sequence=VSP_004312;
CC -!- TISSUE SPECIFICITY: Somatic.
CC -!- PTM: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515
CC kDa large extracellular domain (LRP-515) that remains non-covalently
CC associated.
CC -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
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DR EMBL; X74904; CAA52870.1; -; mRNA.
DR PIR; A53102; A53102.
DR RefSeq; NP_990573.1; NM_205242.1.
DR SMR; P98157; -.
DR STRING; 9031.ENSGALP00000040865; -.
DR PaxDb; P98157; -.
DR PRIDE; P98157; -.
DR GeneID; 396170; -.
DR KEGG; gga:396170; -.
DR CTD; 4035; -.
DR VEuPathDB; HostDB:geneid_396170; -.
DR eggNOG; KOG1215; Eukaryota.
DR InParanoid; P98157; -.
DR OrthoDB; 1606at2759; -.
DR PhylomeDB; P98157; -.
DR PRO; PR:P98157; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016964; F:alpha-2 macroglobulin receptor activity; ISS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00112; LDLa; 30.
DR Gene3D; 2.120.10.30; -; 8.
DR Gene3D; 4.10.400.10; -; 30.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR032485; DUF5050.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF16472; DUF5050; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 30.
DR Pfam; PF00058; Ldl_recept_b; 13.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 24.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00192; LDLa; 31.
DR SMART; SM00135; LY; 37.
DR SUPFAM; SSF57184; SSF57184; 3.
DR SUPFAM; SSF57424; SSF57424; 30.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 5.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 27.
DR PROSITE; PS50068; LDLRA_2; 31.
DR PROSITE; PS51120; LDLRB; 34.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Coated pit; Disulfide bond; EGF-like domain;
KW Endocytosis; Glycoprotein; Membrane; Metal-binding; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..4543
FT /note="Low-density lipoprotein receptor-related protein 1"
FT /id="PRO_0000017318"
FT TOPO_DOM 22..4419
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 4420..4443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 4444..4543
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 27..68
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 72..112
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 113..151
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 152..191
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 294..336
FT /note="LDL-receptor class B 1"
FT REPEAT 337..380
FT /note="LDL-receptor class B 2"
FT REPEAT 381..424
FT /note="LDL-receptor class B 3"
FT DOMAIN 476..522
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 573..615
FT /note="LDL-receptor class B 4"
FT REPEAT 616..661
FT /note="LDL-receptor class B 5"
FT REPEAT 662..712
FT /note="LDL-receptor class B 6"
FT REPEAT 713..756
FT /note="LDL-receptor class B 7"
FT DOMAIN 801..841
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 850..890
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 891..931
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 932..971
FT /note="LDL-receptor class A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 972..1011
FT /note="LDL-receptor class A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1011..1051
FT /note="LDL-receptor class A 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1058..1097
FT /note="LDL-receptor class A 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1100..1140
FT /note="LDL-receptor class A 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1141..1180
FT /note="LDL-receptor class A 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1181..1220
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1221..1260
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 1307..1353
FT /note="LDL-receptor class B 8"
FT REPEAT 1354..1396
FT /note="LDL-receptor class B 9"
FT REPEAT 1397..1443
FT /note="LDL-receptor class B 10"
FT REPEAT 1444..1488
FT /note="LDL-receptor class B 11"
FT REPEAT 1489..1529
FT /note="LDL-receptor class B 12"
FT DOMAIN 1534..1577
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 1625..1667
FT /note="LDL-receptor class B 13"
FT REPEAT 1668..1711
FT /note="LDL-receptor class B 14"
FT REPEAT 1712..1751
FT /note="LDL-receptor class B 15"
FT REPEAT 1752..1796
FT /note="LDL-receptor class B 16"
FT DOMAIN 1842..1883
FT /note="EGF-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 1930..1972
FT /note="LDL-receptor class B 17"
FT REPEAT 1973..2015
FT /note="LDL-receptor class B 18"
FT REPEAT 2016..2059
FT /note="LDL-receptor class B 19"
FT REPEAT 2060..2103
FT /note="LDL-receptor class B 20"
FT DOMAIN 2151..2191
FT /note="EGF-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 2247..2288
FT /note="LDL-receptor class B 21"
FT REPEAT 2289..2337
FT /note="LDL-receptor class B 22"
FT REPEAT 2338..2382
FT /note="LDL-receptor class B 23"
FT REPEAT 2383..2425
FT /note="LDL-receptor class B 24"
FT REPEAT 2426..2467
FT /note="LDL-receptor class B 25"
FT DOMAIN 2472..2512
FT /note="EGF-like 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2516..2557
FT /note="LDL-receptor class A 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2558..2596
FT /note="LDL-receptor class A 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2597..2635
FT /note="LDL-receptor class A 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2636..2684
FT /note="LDL-receptor class A 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2688..2730
FT /note="LDL-receptor class A 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2730..2769
FT /note="LDL-receptor class A 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2770..2812
FT /note="LDL-receptor class A 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2814..2853
FT /note="LDL-receptor class A 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2854..2897
FT /note="LDL-receptor class A 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2900..2938
FT /note="LDL-receptor class A 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2939..2978
FT /note="EGF-like 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2979..3019
FT /note="EGF-like 12; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 3066..3110
FT /note="LDL-receptor class B 26"
FT REPEAT 3111..3153
FT /note="LDL-receptor class B 27"
FT REPEAT 3154..3197
FT /note="LDL-receptor class B 28"
FT REPEAT 3198..3240
FT /note="LDL-receptor class B 29"
FT REPEAT 3241..3281
FT /note="LDL-receptor class B 30"
FT DOMAIN 3287..3328
FT /note="EGF-like 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3329..3368
FT /note="LDL-receptor class A 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3369..3407
FT /note="LDL-receptor class A 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3408..3447
FT /note="LDL-receptor class A 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3448..3488
FT /note="LDL-receptor class A 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3489..3530
FT /note="LDL-receptor class A 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3531..3569
FT /note="LDL-receptor class A 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3570..3608
FT /note="LDL-receptor class A 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3608..3646
FT /note="LDL-receptor class A 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3649..3689
FT /note="LDL-receptor class A 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3690..3730
FT /note="LDL-receptor class A 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3736..3776
FT /note="LDL-receptor class A 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3779..3821
FT /note="EGF-like 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3822..3859
FT /note="EGF-like 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 3910..3952
FT /note="LDL-receptor class B 31"
FT REPEAT 3969..4011
FT /note="LDL-receptor class B 32"
FT REPEAT 4012..4055
FT /note="LDL-receptor class B 33"
FT REPEAT 4056..4100
FT /note="LDL-receptor class B 34"
FT DOMAIN 4146..4182
FT /note="EGF-like 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4195..4231
FT /note="EGF-like 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4231..4267
FT /note="EGF-like 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4267..4303
FT /note="EGF-like 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4303..4339
FT /note="EGF-like 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4339..4374
FT /note="EGF-like 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4372..4409
FT /note="EGF-like 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 4522..4543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 3939..3942
FT /note="Recognition site for proteolytical processing"
FT /evidence="ECO:0000255"
FT MOTIF 4501..4506
FT /note="NPXY motif"
FT BINDING 869
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 872
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 874
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 876
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 882
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 883
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 1030
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 1033
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 1035
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 1037
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 1043
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 1044
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 1078
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 1081
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 1083
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 1085
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 1091
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 1092
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 138
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 359
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 448
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 731
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 926
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1048
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1153
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1216
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1305
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1509
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1556
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1573
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1614
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1643
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1721
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1731
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1761
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1823
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1929
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1991
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2044
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2123
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2466
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2496
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2515
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2595
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2614
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2632
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2813
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2903
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3045
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3086
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3330
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3485
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3659
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3786
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3837
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3952
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4074
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4278
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..42
FT /evidence="ECO:0000250"
FT DISULFID 36..55
FT /evidence="ECO:0000250"
FT DISULFID 49..66
FT /evidence="ECO:0000250"
FT DISULFID 74..87
FT /evidence="ECO:0000250"
FT DISULFID 81..100
FT /evidence="ECO:0000250"
FT DISULFID 94..110
FT /evidence="ECO:0000250"
FT DISULFID 117..126
FT /evidence="ECO:0000250"
FT DISULFID 122..135
FT /evidence="ECO:0000250"
FT DISULFID 137..150
FT /evidence="ECO:0000250"
FT DISULFID 156..166
FT /evidence="ECO:0000250"
FT DISULFID 162..175
FT /evidence="ECO:0000250"
FT DISULFID 177..190
FT /evidence="ECO:0000250"
FT DISULFID 480..495
FT /evidence="ECO:0000250"
FT DISULFID 491..506
FT /evidence="ECO:0000250"
FT DISULFID 508..521
FT /evidence="ECO:0000250"
FT DISULFID 805..816
FT /evidence="ECO:0000250"
FT DISULFID 812..825
FT /evidence="ECO:0000250"
FT DISULFID 827..840
FT /evidence="ECO:0000250"
FT DISULFID 852..864
FT /evidence="ECO:0000250"
FT DISULFID 859..877
FT /evidence="ECO:0000250"
FT DISULFID 871..888
FT /evidence="ECO:0000250"
FT DISULFID 893..905
FT /evidence="ECO:0000250"
FT DISULFID 900..918
FT /evidence="ECO:0000250"
FT DISULFID 912..929
FT /evidence="ECO:0000250"
FT DISULFID 934..946
FT /evidence="ECO:0000250"
FT DISULFID 941..959
FT /evidence="ECO:0000250"
FT DISULFID 953..969
FT /evidence="ECO:0000250"
FT DISULFID 974..987
FT /evidence="ECO:0000250"
FT DISULFID 982..1000
FT /evidence="ECO:0000250"
FT DISULFID 994..1009
FT /evidence="ECO:0000250"
FT DISULFID 1013..1025
FT /evidence="ECO:0000250"
FT DISULFID 1020..1038
FT /evidence="ECO:0000250"
FT DISULFID 1032..1049
FT /evidence="ECO:0000250"
FT DISULFID 1060..1073
FT /evidence="ECO:0000250"
FT DISULFID 1067..1086
FT /evidence="ECO:0000250"
FT DISULFID 1080..1095
FT /evidence="ECO:0000250"
FT DISULFID 1102..1116
FT /evidence="ECO:0000250"
FT DISULFID 1110..1129
FT /evidence="ECO:0000250"
FT DISULFID 1123..1138
FT /evidence="ECO:0000250"
FT DISULFID 1143..1157
FT /evidence="ECO:0000250"
FT DISULFID 1150..1170
FT /evidence="ECO:0000250"
FT DISULFID 1164..1180
FT /evidence="ECO:0000250"
FT DISULFID 1183..1194
FT /evidence="ECO:0000250"
FT DISULFID 1190..1204
FT /evidence="ECO:0000250"
FT DISULFID 1206..1219
FT /evidence="ECO:0000250"
FT DISULFID 1225..1235
FT /evidence="ECO:0000250"
FT DISULFID 1231..1244
FT /evidence="ECO:0000250"
FT DISULFID 1246..1259
FT /evidence="ECO:0000250"
FT DISULFID 1538..1551
FT /evidence="ECO:0000250"
FT DISULFID 1547..1561
FT /evidence="ECO:0000250"
FT DISULFID 1563..1576
FT /evidence="ECO:0000250"
FT DISULFID 1846..1857
FT /evidence="ECO:0000250"
FT DISULFID 1853..1867
FT /evidence="ECO:0000250"
FT DISULFID 1869..1882
FT /evidence="ECO:0000250"
FT DISULFID 2155..2166
FT /evidence="ECO:0000250"
FT DISULFID 2162..2176
FT /evidence="ECO:0000250"
FT DISULFID 2178..2190
FT /evidence="ECO:0000250"
FT DISULFID 2476..2487
FT /evidence="ECO:0000250"
FT DISULFID 2483..2497
FT /evidence="ECO:0000250"
FT DISULFID 2499..2511
FT /evidence="ECO:0000250"
FT DISULFID 2518..2531
FT /evidence="ECO:0000250"
FT DISULFID 2526..2544
FT /evidence="ECO:0000250"
FT DISULFID 2538..2555
FT /evidence="ECO:0000250"
FT DISULFID 2560..2572
FT /evidence="ECO:0000250"
FT DISULFID 2567..2585
FT /evidence="ECO:0000250"
FT DISULFID 2579..2594
FT /evidence="ECO:0000250"
FT DISULFID 2599..2611
FT /evidence="ECO:0000250"
FT DISULFID 2606..2624
FT /evidence="ECO:0000250"
FT DISULFID 2618..2633
FT /evidence="ECO:0000250"
FT DISULFID 2638..2660
FT /evidence="ECO:0000250"
FT DISULFID 2654..2673
FT /evidence="ECO:0000250"
FT DISULFID 2667..2682
FT /evidence="ECO:0000250"
FT DISULFID 2690..2702
FT /evidence="ECO:0000250"
FT DISULFID 2697..2715
FT /evidence="ECO:0000250"
FT DISULFID 2709..2724
FT /evidence="ECO:0000250"
FT DISULFID 2732..2744
FT /evidence="ECO:0000250"
FT DISULFID 2739..2757
FT /evidence="ECO:0000250"
FT DISULFID 2751..2767
FT /evidence="ECO:0000250"
FT DISULFID 2772..2785
FT /evidence="ECO:0000250"
FT DISULFID 2779..2798
FT /evidence="ECO:0000250"
FT DISULFID 2792..2810
FT /evidence="ECO:0000250"
FT DISULFID 2816..2828
FT /evidence="ECO:0000250"
FT DISULFID 2823..2841
FT /evidence="ECO:0000250"
FT DISULFID 2835..2851
FT /evidence="ECO:0000250"
FT DISULFID 2856..2868
FT /evidence="ECO:0000250"
FT DISULFID 2863..2882
FT /evidence="ECO:0000250"
FT DISULFID 2876..2895
FT /evidence="ECO:0000250"
FT DISULFID 2902..2914
FT /evidence="ECO:0000250"
FT DISULFID 2909..2927
FT /evidence="ECO:0000250"
FT DISULFID 2921..2936
FT /evidence="ECO:0000250"
FT DISULFID 2941..2953
FT /evidence="ECO:0000250"
FT DISULFID 2949..2962
FT /evidence="ECO:0000250"
FT DISULFID 2964..2977
FT /evidence="ECO:0000250"
FT DISULFID 2983..2993
FT /evidence="ECO:0000250"
FT DISULFID 2989..3002
FT /evidence="ECO:0000250"
FT DISULFID 3004..3018
FT /evidence="ECO:0000250"
FT DISULFID 3291..3302
FT /evidence="ECO:0000250"
FT DISULFID 3298..3312
FT /evidence="ECO:0000250"
FT DISULFID 3314..3327
FT /evidence="ECO:0000250"
FT DISULFID 3331..3343
FT /evidence="ECO:0000250"
FT DISULFID 3338..3356
FT /evidence="ECO:0000250"
FT DISULFID 3350..3366
FT /evidence="ECO:0000250"
FT DISULFID 3371..3383
FT /evidence="ECO:0000250"
FT DISULFID 3378..3396
FT /evidence="ECO:0000250"
FT DISULFID 3390..3405
FT /evidence="ECO:0000250"
FT DISULFID 3410..3423
FT /evidence="ECO:0000250"
FT DISULFID 3417..3436
FT /evidence="ECO:0000250"
FT DISULFID 3430..3445
FT /evidence="ECO:0000250"
FT DISULFID 3450..3463
FT /evidence="ECO:0000250"
FT DISULFID 3457..3476
FT /evidence="ECO:0000250"
FT DISULFID 3470..3486
FT /evidence="ECO:0000250"
FT DISULFID 3491..3504
FT /evidence="ECO:0000250"
FT DISULFID 3498..3517
FT /evidence="ECO:0000250"
FT DISULFID 3511..3528
FT /evidence="ECO:0000250"
FT DISULFID 3533..3545
FT /evidence="ECO:0000250"
FT DISULFID 3540..3558
FT /evidence="ECO:0000250"
FT DISULFID 3552..3567
FT /evidence="ECO:0000250"
FT DISULFID 3572..3584
FT /evidence="ECO:0000250"
FT DISULFID 3579..3597
FT /evidence="ECO:0000250"
FT DISULFID 3591..3606
FT /evidence="ECO:0000250"
FT DISULFID 3610..3622
FT /evidence="ECO:0000250"
FT DISULFID 3617..3635
FT /evidence="ECO:0000250"
FT DISULFID 3629..3644
FT /evidence="ECO:0000250"
FT DISULFID 3658..3676
FT /evidence="ECO:0000250"
FT DISULFID 3670..3687
FT /evidence="ECO:0000250"
FT DISULFID 3692..3706
FT /evidence="ECO:0000250"
FT DISULFID 3700..3719
FT /evidence="ECO:0000250"
FT DISULFID 3713..3728
FT /evidence="ECO:0000250"
FT DISULFID 3738..3752
FT /evidence="ECO:0000250"
FT DISULFID 3747..3765
FT /evidence="ECO:0000250"
FT DISULFID 3759..3774
FT /evidence="ECO:0000250"
FT DISULFID 3783..3796
FT /evidence="ECO:0000250"
FT DISULFID 3790..3805
FT /evidence="ECO:0000250"
FT DISULFID 3807..3820
FT /evidence="ECO:0000250"
FT DISULFID 3826..3836
FT /evidence="ECO:0000250"
FT DISULFID 3832..3845
FT /evidence="ECO:0000250"
FT DISULFID 3847..3858
FT /evidence="ECO:0000250"
FT DISULFID 4150..4159
FT /evidence="ECO:0000250"
FT DISULFID 4155..4168
FT /evidence="ECO:0000250"
FT DISULFID 4170..4181
FT /evidence="ECO:0000250"
FT DISULFID 4199..4209
FT /evidence="ECO:0000250"
FT DISULFID 4203..4219
FT /evidence="ECO:0000250"
FT DISULFID 4221..4230
FT /evidence="ECO:0000250"
FT DISULFID 4235..4245
FT /evidence="ECO:0000250"
FT DISULFID 4239..4255
FT /evidence="ECO:0000250"
FT DISULFID 4257..4266
FT /evidence="ECO:0000250"
FT DISULFID 4271..4281
FT /evidence="ECO:0000250"
FT DISULFID 4275..4291
FT /evidence="ECO:0000250"
FT DISULFID 4293..4302
FT /evidence="ECO:0000250"
FT DISULFID 4307..4317
FT /evidence="ECO:0000250"
FT DISULFID 4311..4327
FT /evidence="ECO:0000250"
FT DISULFID 4329..4338
FT /evidence="ECO:0000250"
FT DISULFID 4343..4351
FT /evidence="ECO:0000250"
FT DISULFID 4346..4362
FT /evidence="ECO:0000250"
FT DISULFID 4364..4373
FT /evidence="ECO:0000250"
FT DISULFID 4376..4386
FT /evidence="ECO:0000250"
FT DISULFID 4380..4397
FT /evidence="ECO:0000250"
FT DISULFID 4399..4408
FT /evidence="ECO:0000250"
FT VAR_SEQ 2725..2729
FT /note="SERQD -> N (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:7506255"
FT /id="VSP_004312"
SQ SEQUENCE 4543 AA; 507133 MW; C8D5823BB868BAD5 CRC64;
MGPLLALAGC LLALLAAPAA RALEAPKTCS PKQFACKDQI TCISKGWRCD GEKDCPDGSD
ESPDICPQSK VSRCQPNEHN CLGTELCIHM SKLCNGLHDC FDGSDEGPHC REQLANCTAL
GCQHHCVPTL SGPACYCNNS FQLAEDRRSC KDFDECTVYG TCSQTCTNTE GSYTCSCVEG
YLLQPDNRSC KAKNEPVDRP PVLLIANSQN ILATYLSGAP VPNITPTSAK QTTAMDFNYI
EDTVCWVHVG DSASQTILKC AKIPNLKGFV EERSINISLS LHQVEQMAID WLTGNFYFVD
DIDDRIFVCN KNGLTCVTLL DLELYNPKGI ALDPAMGKVF FTDYGQIPKV ERCDMDGQNR
TKLVDSKIVF PHGITLDLVS RLVYWADAYL DYIEVVDYEG KNRHTIIQGI LIEHLYGLTV
FENYLYATNS DNANAQQKTS VIRVNRFNST EYQVVTRVDK GGALHIYHQR RQPTVRSHAC
EPDQFGKPGG CSDICLLGNS HKSRTCRCRS GFSLGSDGKS CKKPEHELFL VYGKGRPGII
RGMDMGAKVP DEHMIPIENL MNPRALDFHA ETGFIYFADT TSYLIGRQKI DGTERETILK
DGIHNVEGIA VDWMGNNLYW TDDGPKKTIS VARLEKAAQT RKTLIEGKMT HPRAIVVDPL
NGWMYWTDWE EDPKDSKRGK IERAWMDGSN RNVFITSKTV LWPNGLSLDI PAKILYWVDA
FYDRIEMVYL NGTERKIVYE GPELNHAFGL CHYSSFLFWT EYRSGSIYRL DQSSKAVSLL
RNERPPIFEI RMYDAQQQQV GSNKCRVNNG GCSSLCLATP RGRQCACAED QILGADSVTC
EANPSYIPPP QCQPGEFACK NNRCIQERWK CDGDNDCLDN SDEAPELCHQ HTCPSDRFKC
KNNRCIPNRW LCDGDNDCGN NEDESNSTCS ARTCSPNQFS CASGRCIPIS WTCDLDDDCG
DRSDESASCA YPTCFPLTQF TCNNGRCINI NWRCDNDNDC GDNSDEAGCS HSCSSNQFKC
NSGRCIPVHW TCDGDNDCGD YSDETHANCT NQATRPPGGC HTDEFQCRLD GLCIPMRWRC
DGDTDCMDSS DEKNCEGVTH VCDPNVKFGC KDSARCISKA WVCDGDSDCE DNSDEENCES
LVCKPPSHTC ANNTSICLPP EKLCDGSDDC GDGSDEGELC DQCSLNNGGC SHNCTVAPGE
GIVCSCPLGM ELGADNKTCQ IQSYCAKHLK CSQKCEQDKY NVKCSCYEGW MLEPDGESCR
SLDPFKPFII FSNRHEIRRI DLHRGDYSVL VPGLRNTIAL DFHLNQSSLY WTDVVEDKIY
RGKLLENGAL TSFEVVIQYG LATPEGLAVD WIAGNIYWVE SNLDQIEVAK LDGTMRTTLL
AGDIEHPRAI ALDPRYGILF WTDWDASLPR IEAASMSGAG RRTIHKETGS GGWPNGLTVD
YLEKRILWID ARSDAIYSAL YDGTGHIEVL RGHEYLSHPF AVTLYGGEVY WTDWRTNTLA
KANKWTGHNV TVVQRTNTQP FDLQVYHPSR QPLAPNPCEA NGGKGPCSHL CLINYNRTLS
CACPHLMKLD KDNTTCYEFK KFLLYARQME IRGVDIDNPY YNYIISFTVP DIDNVTVVDY
DAVEQRIYWS DVRTQTIKRA FINGTGVETV VSADLPNAHG LSVDWVSRNL FWTSYDTNKK
QINVARLDGS FKNAVIQGLD KPHCLVVHPL HGKLYWTDGD NISVANMDGS NRTLLFTNQR
GPVGLAIDYP ESKLYWISSG NGTINRCNLD GSDLEVIVAV KSQLSKATAL AIMGDKLWWA
DQASERMGTC NKKDGTEVTV LRNSTTLVML MKVYDESIQQ AGSNPCSVNN GDCSQLCLPT
SETSRSCMCT AGYSLKSGQQ SCEGVGSFLL YSVHEGIRGI PLDPNDKSDA LVPVSGTSLA
VGIDFHAEND TIYWVDMGLS TISRAKRDQT WREDVVTNGI GRVEGIAVDW IAGNIYWTDQ
GFDVIEVARL NGSFRYVVIS QGLDKPRAIT VHPEKGYLFW TEWGQYPRIE RSRLDGTERM
VLVNVSISWP NGISVDYEDG KLYWCDARTD KIERIDLETG ENREVVLSSD NMDMFSVSVF
EDYIYWSDRT HANGSIKRGS KDNATESVSL RTGIGVQLKD IKVFNRARQK GTNVCAQNNG
GCQQLCLFRG GGRRTCACAH GMLSEDGVSC RDYDGYLLYS ERTILKSIHL SDENNLNAPI
KPFEDAEHMK NVIALAFDYR YGTKGSNRIF YSDIHFGNIQ QINDDGTGRR TIVENVGSVE
GLAYHRGWDT LYWTSYTTST ITRHTVDQSR LGAFERETVI TMSGDDHPRA FVLDECQNLM
FWTNWNEQHP SIMRATLSGA NVLIIIDQDI RTPNGLAIDH RAEKIYFSDA TLDKIERCEY
DGSHRHVILK SEPVHPFGLA VYGDYIFWTD WVRRAVQRAN KYVGTDMKLL RVDIPQQPMG
IIAVANDTDS CELSPCRVNN GGCQDLCLLT PKGHVNCSCR GERVLQEDFT CKALNSTCNV
HDEFECGNGD CIDFSRTCDG VVHCKDKSDE KQSYCSSRKC KKGFLHCMNG RCVASRFWCN
GVDDCGDNSD EVPCNKTSCA ATEFRCRDGS CIGNSSRCNQ FIDCEDASDE MNCTATDCSS
YFKLGVKGTT FQKCEHTSLC YAPSWVCDGA NDCGDYSDER NCPGGRKPKC PANYFACPSG
RCIPMTWTCD KEDDCENGED ETHCSERQDK FCYPVQFECN NHRCISKLWV CDGADDCGDG
SDEDSRCRLT TCSTGSFQCP GTYVCVPERW LCDGDKDCAD GADETLAAGC LYNNTCDERE
FMCGNRQCIP KHFVCDHDDD CGDGSDESPE CEYPTCGPHE FRCANGRCLS NSQWECDGEF
DCHDHSDEAP KNPRCSSPES KCNDSFFMCK NGKCIPEALL CDNNNDCADG SDELNCFINE
CLNKKLSGCS QECEDLKIGY KCRCRPGFRL KDDGKTCIDI DECSTTYPCS QKCINTLGSY
KCLCIEGYKL KPDNPTSCKA VTDEEPFLIF ANRYYLRKLN LDGSNYTLLK QGLNNAVALD
FDYREQMIYW TDVTTQGSMI RRMHINGSNV QVLHRTGLSN PDGLAVDWVG GNLYWCDKGR
DTIEVSKLNG AYRTVLVNSG LREPRALVVD VQNGYLYWTD WGDHSLIGKI GMDGTNRSVI
VDTKITWPNG LTLDYINSRI YWADAREDYI EFASLDGSNR HTVLSQDIPH IFALTLFEDY
IYWTDWETKS INRAHKTTGA NKTLLISTLH RPMDIHIYHP YRQPDVPNHP CKTNNAGCSN
LCLLSPGGGH KCACPTNFYL GSDGKTCVSN CTASQFVCKN DKCIPFWWKC DTEDDCGDRS
DEPEDCPEFK CRPGQFQCST GICTNPAFIC DGDNDCQDNS DEANCDIHVC LPSQFKCTNT
NRCIPGIFRC NGQDNCGDGE DEKDCPEVTC APNQFQCAIT KRCIPRVWVC DRDNDCVDGS
DEPANCTQMT CGVDEFRCKD SGRCIPARWK CDGEDDCGDG SDEPKEECDE RTCEPYQFRC
KNNRCVPGRW QCDYDNDCGD NSDEESCTPR PCSESEFSCA NGRCIAGRWK CDGDHDCADG
SDEKDCIPRC EFDQYQCKNG HCIPMRWRCD ADADCMDGTD EEDCGTGVRT CPLDEFQCNN
TLRKPLAWKC DGEDDCGDNS DENPEECLKF QCPPNRPFRC KNDRVCLWIG RQCDGIDNCG
DNTDEKDCES PTAKPKSCSQ DKNEFLCENK KCISANLRCN FFDDCGDGSD EKSCSHEHKS
YDCMTNTTMC GDEAQCIQAQ SSTYCTCRRG FQKVPDKNSC QDVNECLRFG TCSQLCNNTK
GSHVCSCAKN FMKTDNMCKA EGSEHQILYI ADDNKIRSMY PFNPNSAYEP AFQGDENVRI
DAMDIYVKGN KIYWTNWHTG RISYCELPAS SAASTASNRN RRQIDGGVTH LNISGLKMPR
GIAVDWVAGN IYWTDSGRDV IEVAQMKGEN RKTLISGMID EPHAIVVDPL RGTMYWSDWG
NHPKIETAAM DGTLRETLVQ DNIQWPTGLA VDYHNERLYW ADAKLSVIGS IRLNGTDPVV
AIDNKKGLSH PFSIDIFEDY IYGVTYINNR IFKIHKFGHK SVTNLTSGLN HATDVVLYHQ
YKQPEVTNPC DRKKCEWLCL LSPSGPVCTC PNGKRLDNGT CVLIPSPTAS AVVPTTDTCD
LVCLNGGSCF LNARKQAKCR CQPRYNGERC QINQCSDYCQ NGGLCTASPS GMPTCRCPTG
FTGSRCDQQV CTNYCHNNGS CTVNQGNQPN CRCPPTFIGD RCQYQQCFNY CENNGVCQMS
RDGVKQCRCP PQFEGAQCQD NKCSRCQEGK CNINRQSGDV SCICPDGKIA PSCLTCDSYC
LNGGTCSISD KTQLPECLCP LEVTGMRCEE FIVGEQQSGR TASIVIPILL LLLLLAVVAF
AWYKWRIKGA KGFQHQRMTN GAMNVEIGNP TYKMYEGEPD DDVGELLDAD FALDPDKPTN
FTNPVYATLY MGAHSSRNSL ASTDEKRELL ARGADDDLTD PLA
