LRP6A_ARATH
ID LRP6A_ARATH Reviewed; 422 AA.
AC Q94A38; A8MS45; F4KG39; Q9FL36;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=La-related protein 6A;
DE Short=AtLARP6a;
GN Name=LARP6A; OrderedLocusNames=At5g46250; ORFNames=MPL12.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19299548; DOI=10.1261/rna.1478709;
RA Bousquet-Antonelli C., Deragon J.M.;
RT "A comprehensive analysis of the La-motif protein superfamily.";
RL RNA 15:750-764(2009).
CC -!- FUNCTION: Transcriptional regulator. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q94A38-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q94A38-2; Sequence=VSP_054174, VSP_054175;
CC Name=3;
CC IsoId=Q94A38-3; Sequence=VSP_054173, VSP_054174, VSP_054175;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11080.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB010698; BAB11080.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002688; AED95357.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95358.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95359.1; -; Genomic_DNA.
DR EMBL; AY050403; AAK91419.1; -; mRNA.
DR EMBL; BT000588; AAN18157.1; -; mRNA.
DR RefSeq; NP_001078721.1; NM_001085252.1. [Q94A38-3]
DR RefSeq; NP_568660.3; NM_123994.4. [Q94A38-2]
DR RefSeq; NP_851141.1; NM_180810.3. [Q94A38-1]
DR AlphaFoldDB; Q94A38; -.
DR SMR; Q94A38; -.
DR BioGRID; 19916; 2.
DR IntAct; Q94A38; 2.
DR STRING; 3702.AT5G46250.1; -.
DR iPTMnet; Q94A38; -.
DR PaxDb; Q94A38; -.
DR PRIDE; Q94A38; -.
DR ProteomicsDB; 238592; -. [Q94A38-1]
DR EnsemblPlants; AT5G46250.1; AT5G46250.1; AT5G46250. [Q94A38-1]
DR EnsemblPlants; AT5G46250.2; AT5G46250.2; AT5G46250. [Q94A38-2]
DR EnsemblPlants; AT5G46250.3; AT5G46250.3; AT5G46250. [Q94A38-3]
DR GeneID; 834667; -.
DR Gramene; AT5G46250.1; AT5G46250.1; AT5G46250. [Q94A38-1]
DR Gramene; AT5G46250.2; AT5G46250.2; AT5G46250. [Q94A38-2]
DR Gramene; AT5G46250.3; AT5G46250.3; AT5G46250. [Q94A38-3]
DR KEGG; ath:AT5G46250; -.
DR Araport; AT5G46250; -.
DR TAIR; locus:2170478; AT5G46250.
DR eggNOG; KOG1855; Eukaryota.
DR InParanoid; Q94A38; -.
DR OMA; NEEDWRN; -.
DR OrthoDB; 882725at2759; -.
DR PhylomeDB; Q94A38; -.
DR PRO; PR:Q94A38; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q94A38; baseline and differential.
DR Genevisible; Q94A38; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005844; C:polysome; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd12288; RRM_La_like_plant; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR034878; La-rel_plant_RRM.
DR InterPro; IPR045180; La_dom_prot.
DR InterPro; IPR006630; La_HTH.
DR InterPro; IPR002344; Lupus_La.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22792; PTHR22792; 1.
DR Pfam; PF05383; La; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PRINTS; PR00302; LUPUSLA.
DR SMART; SM00715; LA; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50961; HTH_LA; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome; RNA-binding;
KW Transcription; Transcription regulation.
FT CHAIN 1..422
FT /note="La-related protein 6A"
FT /id="PRO_0000428669"
FT DOMAIN 97..188
FT /note="HTH La-type RNA-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00332"
FT DOMAIN 193..283
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 263..264
FT /note="AA -> VT (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_054173"
FT VAR_SEQ 338..340
FT /note="DGG -> VKG (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_054174"
FT VAR_SEQ 341..422
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_054175"
SQ SEQUENCE 422 AA; 46842 MW; 4EC4BBBF1E068F0E CRC64;
MSSLPLRSGE KMESPSISDA VPLHAPEDAT ADFSQPQSPL HEVDSFPVTE SSDDVVVNVS
EIPNLSPSDD DFDHERNSGE DRDQDHGENP VETDGVVVPI DELNQKIIRQ VEYYFSDENL
PTDKFLLNAM KRNKKGFVPI STIATFHKMK KLTRDHALIV SALKESSFLV VSADEKKVKR
LSPLPEIRDP KIFTVLVENL PEDHSNENIR EIFGKAGSIK SVSICDPNAV EESEKGGKKE
NFIRTRLHAF VEYETVEAAE KAAATLNNEQ DWRNGLRVKL LEQAAGKFAQ RRPARREVDK
EKDTTGRVHD QTGGEKNKKT REHQNHRLHH SDNPADDDGG NHQKDKNGNK GRVVGQGRRQ
NHQGGNGIGH GTASSSSHPN YHPVEVSKRP PGPRMPDGTR GFTMGRGKAI PPPTSTQTSH
EV
