ID   LRP6C_ARATH             Reviewed;         455 AA.
AC   Q9LHL3;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=La-related protein 6C;
DE            Short=AtLARP6c;
GN   Name=LARP6C; OrderedLocusNames=At3g19090; ORFNames=MHP21.1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA   Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT   features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT   clones.";
RL   DNA Res. 7:217-221(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19299548; DOI=10.1261/rna.1478709;
RA   Bousquet-Antonelli C., Deragon J.M.;
RT   "A comprehensive analysis of the La-motif protein superfamily.";
RL   RNA 15:750-764(2009).
CC   -!- FUNCTION: Transcriptional regulator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; AP002041; BAB02607.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE76193.1; -; Genomic_DNA.
DR   RefSeq; NP_188540.1; NM_112796.2.
DR   AlphaFoldDB; Q9LHL3; -.
DR   SMR; Q9LHL3; -.
DR   BioGRID; 6777; 1.
DR   STRING; 3702.AT3G19090.1; -.
DR   PaxDb; Q9LHL3; -.
DR   PRIDE; Q9LHL3; -.
DR   ProteomicsDB; 238632; -.
DR   EnsemblPlants; AT3G19090.1; AT3G19090.1; AT3G19090.
DR   GeneID; 821444; -.
DR   Gramene; AT3G19090.1; AT3G19090.1; AT3G19090.
DR   KEGG; ath:AT3G19090; -.
DR   Araport; AT3G19090; -.
DR   TAIR; locus:2089508; AT3G19090.
DR   eggNOG; KOG1855; Eukaryota.
DR   HOGENOM; CLU_033595_0_0_1; -.
DR   InParanoid; Q9LHL3; -.
DR   PhylomeDB; Q9LHL3; -.
DR   PRO; PR:Q9LHL3; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LHL3; baseline and differential.
DR   Genevisible; Q9LHL3; AT.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005844; C:polysome; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd12288; RRM_La_like_plant; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR009818; Ataxin-2_C.
DR   InterPro; IPR034878; La-rel_plant_RRM.
DR   InterPro; IPR045180; La_dom_prot.
DR   InterPro; IPR006630; La_HTH.
DR   InterPro; IPR002344; Lupus_La.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR22792; PTHR22792; 1.
DR   Pfam; PF05383; La; 1.
DR   Pfam; PF07145; PAM2; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PRINTS; PR00302; LUPUSLA.
DR   SMART; SM00715; LA; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50961; HTH_LA; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..455
FT                   /note="La-related protein 6C"
FT                   /id="PRO_0000428671"
FT   DOMAIN          138..229
FT                   /note="HTH La-type RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00332"
FT   DOMAIN          236..324
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          348..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..366
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   455 AA;  48959 MW;  E88117B22C33BBA9 CRC64;
     MAQMQREEVE SVTTEKKRLD GGGGSSGAQA TAFKFNAQAP EFVPRSHTTA PAPQVSPVSG
     YFYPCFHYNG GCIGGCGGGV CGGGGTGVGT QSSDWIYVGG GDPTAQHQHV HDPAAAFYIS
     NPAVQFPASQ NSSSSSKNLL SDDLRLKIVK QVEYQFTDMS LLANESISKH ISKDPEGYVP
     VSYIASTKKI KALTSNHHLV SLALRSSSKL VVSEDGKKVK RTSQFTDRDR EELQGRTVVA
     ENLPDDHSYQ NLEKIFGVVG NVKAIRICHP PESNSSRPKG DFLMSNKIHA LIEYDNTVIA
     DKAVEKLNDE RNWRKGLRVR LLLRCSPKSV LKNRRNFDGI LIDDELPSYE SGEDSPRLHL
     TESQLDNDGD DNNVGGLWGK GRGKGRGRSP RSYAVGGGGR SFGIGLGVSL GIPSLGSHES
     SSPKTATKGP RMPDGTRGFT MGRGKPSISL SPNNL