ID   LRPA1_HALS3             Reviewed;         142 AA.
AC   B0R4X4;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=HTH-type transcriptional regulator LrpA1;
GN   Name=lrpA1; OrderedLocusNames=OE_2621R;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
RN   [2]
RP   FUNCTION, DNA-BINDING, DISRUPTION PHENOTYPE, AND INDUCTION.
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=20509863; DOI=10.1186/1471-2199-11-40;
RA   Schwaiger R., Schwarz C., Furtwangler K., Tarasov V., Wende A.,
RA   Oesterhelt D.;
RT   "Transcriptional control by two leucine-responsive regulatory proteins in
RT   Halobacterium salinarum R1.";
RL   BMC Mol. Biol. 11:40-40(2010).
CC   -!- FUNCTION: Transcription factor that regulates genes involved in amino
CC       acid metabolism. Represses the aspB3 gene, coding for an aspartate
CC       transaminase, in the presence of L-aspartate. Another target gene is
CC       the basal transcriptional regulator tfbB. Binds also its own promoter.
CC       {ECO:0000269|PubMed:20509863}.
CC   -!- INDUCTION: Transcripts accumulate during exponential growth. Is also
CC       subject to negative autoregulation. {ECO:0000269|PubMed:20509863}.
CC   -!- DISRUPTION PHENOTYPE: Leads to strong induction of aspB3 and OE_6130F.
CC       {ECO:0000269|PubMed:20509863}.
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DR   EMBL; AM774415; CAP13789.1; -; Genomic_DNA.
DR   RefSeq; WP_010902807.1; NC_010364.1.
DR   AlphaFoldDB; B0R4X4; -.
DR   SMR; B0R4X4; -.
DR   EnsemblBacteria; CAP13789; CAP13789; OE_2621R.
DR   GeneID; 5953569; -.
DR   GeneID; 62886645; -.
DR   KEGG; hsl:OE_2621R; -.
DR   HOGENOM; CLU_091233_5_4_2; -.
DR   OMA; EDCWFIA; -.
DR   PhylomeDB; B0R4X4; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..142
FT                   /note="HTH-type transcriptional regulator LrpA1"
FT                   /id="PRO_0000428913"
FT   DOMAIN          1..72
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
SQ   SEQUENCE   142 AA;  15179 MW;  13B5DC90641B8F46 CRC64;
     MSTESTEERI LAALEEDAQA SYAAIAERAD VSKPTVRKYI DQLESDGVIV GYSADVDPKK
     LSGQSIAMVG IDVASEQYVE ATRTLQELDS VQALYSSSGD HMLMAEVRAA DGDALGDVIS
     DEVLAIDGVT AAHPSFLQER LK