LRPC_BACSU
ID LRPC_BACSU Reviewed; 144 AA.
AC P96582;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=HTH-type transcriptional regulator LrpC;
GN Name=lrpC; Synonyms=ydaI; OrderedLocusNames=BSU04250;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT subtilis genome.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP CHARACTERIZATION.
RX PubMed=9341680; DOI=10.1007/s004380050546;
RA Beloin C., Ayora S., Exley R., Hirschbein L., Ogasawara N., Kasahara Y.,
RA Alonso J.C., Le Hegarat F.;
RT "Characterization of an lrp-like (lrpC) gene from Bacillus subtilis.";
RL Mol. Gen. Genet. 256:63-71(1997).
CC -!- FUNCTION: Transcriptional regulator with a possible role in regulation
CC of amino acid metabolism. Plays a role in the growth phase transition.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA19262.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB001488; BAA19262.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL009126; CAB12232.1; -; Genomic_DNA.
DR PIR; F69653; F69653.
DR RefSeq; NP_388306.1; NC_000964.3.
DR RefSeq; WP_003246585.1; NZ_JNCM01000031.1.
DR PDB; 2CFX; X-ray; 2.40 A; A/B/C/D/E/F/G/H=1-144.
DR PDBsum; 2CFX; -.
DR AlphaFoldDB; P96582; -.
DR SMR; P96582; -.
DR STRING; 224308.BSU04250; -.
DR PaxDb; P96582; -.
DR PRIDE; P96582; -.
DR EnsemblBacteria; CAB12232; CAB12232; BSU_04250.
DR GeneID; 940147; -.
DR KEGG; bsu:BSU04250; -.
DR PATRIC; fig|224308.179.peg.451; -.
DR eggNOG; COG1522; Bacteria.
DR InParanoid; P96582; -.
DR OMA; VSMRQED; -.
DR PhylomeDB; P96582; -.
DR BioCyc; BSUB:BSU04250-MON; -.
DR EvolutionaryTrace; P96582; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01037; AsnC_trans_reg; 1.
DR PRINTS; PR00033; HTHASNC.
DR SMART; SM00344; HTH_ASNC; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF54909; SSF54909; 1.
DR PROSITE; PS50956; HTH_ASNC_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..144
FT /note="HTH-type transcriptional regulator LrpC"
FT /id="PRO_0000111740"
FT DOMAIN 3..64
FT /note="HTH asnC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT DNA_BIND 22..41
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT HELIX 5..16
FT /evidence="ECO:0007829|PDB:2CFX"
FT HELIX 22..29
FT /evidence="ECO:0007829|PDB:2CFX"
FT HELIX 33..45
FT /evidence="ECO:0007829|PDB:2CFX"
FT STRAND 48..56
FT /evidence="ECO:0007829|PDB:2CFX"
FT HELIX 59..61
FT /evidence="ECO:0007829|PDB:2CFX"
FT STRAND 65..73
FT /evidence="ECO:0007829|PDB:2CFX"
FT HELIX 74..76
FT /evidence="ECO:0007829|PDB:2CFX"
FT HELIX 78..86
FT /evidence="ECO:0007829|PDB:2CFX"
FT STRAND 91..111
FT /evidence="ECO:0007829|PDB:2CFX"
FT HELIX 112..122
FT /evidence="ECO:0007829|PDB:2CFX"
FT TURN 123..125
FT /evidence="ECO:0007829|PDB:2CFX"
FT STRAND 126..136
FT /evidence="ECO:0007829|PDB:2CFX"
SQ SEQUENCE 144 AA; 16450 MW; 78852BE30103417F CRC64;
MKLDQIDLNI IEELKKDSRL SMRELGRKIK LSPPSVTERV RQLESFGIIK QYTLEVDQKK
LGLPVSCIVE ATVKNADYER FKSYIQTLPN IEFCYRIAGA ACYMLKINAE SLEAVEDFIN
KTSPYAQTVT HVIFSEIDTK NGRG
