LRP_CAEEL
ID LRP_CAEEL Reviewed; 4753 AA.
AC Q04833;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Low-density lipoprotein receptor-related protein;
DE Short=LRP;
DE Flags: Precursor;
GN Name=lrp-1; ORFNames=F29D11.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8506301; DOI=10.1073/pnas.90.10.4572;
RA Yochem J., Greenwald I.;
RT "A gene for a low density lipoprotein receptor-related protein in the
RT nematode Caenorhabditis elegans.";
RL Proc. Natl. Acad. Sci. U.S.A. 90:4572-4576(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=12754521; DOI=10.1038/nbt829;
RA Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,
RA Kasai K., Takahashi N., Isobe T.;
RT "Lectin affinity capture, isotope-coded tagging and mass spectrometry to
RT identify N-linked glycoproteins.";
RL Nat. Biotechnol. 21:667-672(2003).
RN [4]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1057; ASN-1597; ASN-1718 AND
RP ASN-4248, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=15888633; DOI=10.1093/glycob/cwi075;
RA Fan X., She Y.-M., Bagshaw R.D., Callahan J.W., Schachter H., Mahuran D.J.;
RT "Identification of the hydrophobic glycoproteins of Caenorhabditis
RT elegans.";
RL Glycobiology 15:952-964(2005).
RN [5]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118; ASN-178; ASN-1431;
RP ASN-1542; ASN-1545; ASN-1597; ASN-1718; ASN-2364; ASN-2762; ASN-3557;
RP ASN-3752 AND ASN-4063, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- FUNCTION: May act as a receptor for the endocytosis of extracellular
CC ligands such as chylomicron remnants, protease-inhibitor complexes and
CC vitellogenin.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC Membrane, coated pit.
CC -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
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DR EMBL; M96150; AAA28105.1; -; Genomic_DNA.
DR EMBL; Z73907; CAA98124.1; -; Genomic_DNA.
DR PIR; A47437; A47437.
DR RefSeq; NP_492127.1; NM_059726.5.
DR SMR; Q04833; -.
DR BioGRID; 37962; 11.
DR STRING; 6239.F29D11.1; -.
DR iPTMnet; Q04833; -.
DR EPD; Q04833; -.
DR PaxDb; Q04833; -.
DR PeptideAtlas; Q04833; -.
DR PRIDE; Q04833; -.
DR EnsemblMetazoa; F29D11.1.1; F29D11.1.1; WBGene00003071.
DR GeneID; 172520; -.
DR UCSC; F29D11.1; c. elegans.
DR CTD; 172520; -.
DR WormBase; F29D11.1; CE05765; WBGene00003071; lrp-1.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000166355; -.
DR HOGENOM; CLU_000085_0_0_1; -.
DR InParanoid; Q04833; -.
DR OMA; RTCQPEQ; -.
DR OrthoDB; 1606at2759; -.
DR PhylomeDB; Q04833; -.
DR PRO; PR:Q04833; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003071; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0016324; C:apical plasma membrane; IDA:WormBase.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR GO; GO:0030139; C:endocytic vesicle; IDA:WormBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0015248; F:sterol transporter activity; IMP:WormBase.
DR GO; GO:0042395; P:ecdysis, collagen and cuticulin-based cuticle; IMP:UniProtKB.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR GO; GO:0040017; P:positive regulation of locomotion; IMP:WormBase.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.
DR GO; GO:0030334; P:regulation of cell migration; IGI:WormBase.
DR GO; GO:0015918; P:sterol transport; IMP:WormBase.
DR CDD; cd00112; LDLa; 31.
DR Gene3D; 2.120.10.30; -; 8.
DR Gene3D; 4.10.400.10; -; 34.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR Pfam; PF00057; Ldl_recept_a; 29.
DR Pfam; PF00058; Ldl_recept_b; 8.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 21.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00192; LDLa; 35.
DR SMART; SM00135; LY; 32.
DR SUPFAM; SSF57184; SSF57184; 2.
DR SUPFAM; SSF57424; SSF57424; 33.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS01209; LDLRA_1; 28.
DR PROSITE; PS50068; LDLRA_2; 34.
DR PROSITE; PS51120; LDLRB; 30.
PE 1: Evidence at protein level;
KW Calcium; Coated pit; Disulfide bond; EGF-like domain; Endocytosis;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..4753
FT /note="Low-density lipoprotein receptor-related protein"
FT /id="PRO_0000017341"
FT TOPO_DOM 19..4570
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 4571..4596
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 4597..4753
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 51..89
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 90..133
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 136..177
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 180..220
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 221..259
FT /note="LDL-receptor class A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 260..298
FT /note="LDL-receptor class A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 299..337
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 338..368
FT /note="EGF-like 2; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 436..482
FT /note="LDL-receptor class B 1"
FT REPEAT 483..525
FT /note="LDL-receptor class B 2"
FT REPEAT 526..566
FT /note="LDL-receptor class B 3"
FT REPEAT 567..609
FT /note="LDL-receptor class B 4"
FT REPEAT 610..654
FT /note="LDL-receptor class B 5"
FT DOMAIN 669..712
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 766..808
FT /note="LDL-receptor class B 6"
FT REPEAT 809..858
FT /note="LDL-receptor class B 7"
FT REPEAT 859..902
FT /note="LDL-receptor class B 8"
FT REPEAT 903..944
FT /note="LDL-receptor class B 9"
FT DOMAIN 997..1043
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1052..1097
FT /note="LDL-receptor class A 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1099..1140
FT /note="LDL-receptor class A 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1144..1184
FT /note="LDL-receptor class A 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1185..1225
FT /note="LDL-receptor class A 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1226..1265
FT /note="LDL-receptor class A 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1268..1309
FT /note="LDL-receptor class A 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1311..1352
FT /note="LDL-receptor class A 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1357..1397
FT /note="LDL-receptor class A 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 1398..1436
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1437..1476
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 1524..1566
FT /note="LDL-receptor class B 10"
FT REPEAT 1567..1610
FT /note="LDL-receptor class B 11"
FT REPEAT 1611..1654
FT /note="LDL-receptor class B 12"
FT REPEAT 1655..1699
FT /note="LDL-receptor class B 13"
FT DOMAIN 1747..1786
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 1894..1942
FT /note="LDL-receptor class B 14"
FT REPEAT 1943..1989
FT /note="LDL-receptor class B 15"
FT REPEAT 1990..2032
FT /note="LDL-receptor class B 16"
FT DOMAIN 2080..2120
FT /note="EGF-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 2215..2259
FT /note="LDL-receptor class B 17"
FT REPEAT 2260..2303
FT /note="LDL-receptor class B 18"
FT REPEAT 2304..2345
FT /note="LDL-receptor class B 19"
FT DOMAIN 2396..2439
FT /note="EGF-like 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 2582..2632
FT /note="LDL-receptor class B 20"
FT REPEAT 2633..2675
FT /note="LDL-receptor class B 21"
FT DOMAIN 2728..2780
FT /note="EGF-like 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2790..2831
FT /note="LDL-receptor class A 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2832..2870
FT /note="LDL-receptor class A 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2872..2914
FT /note="LDL-receptor class A 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2917..2958
FT /note="LDL-receptor class A 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 2959..2999
FT /note="LDL-receptor class A 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3004..3046
FT /note="LDL-receptor class A 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3047..3095
FT /note="LDL-receptor class A 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3098..3137
FT /note="LDL-receptor class A 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3138..3176
FT /note="LDL-receptor class A 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3185..3223
FT /note="LDL-receptor class A 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3224..3265
FT /note="EGF-like 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3266..3306
FT /note="EGF-like 12; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 3354..3401
FT /note="LDL-receptor class B 22"
FT REPEAT 3402..3444
FT /note="LDL-receptor class B 23"
FT REPEAT 3445..3493
FT /note="LDL-receptor class B 24"
FT REPEAT 3494..3536
FT /note="LDL-receptor class B 25"
FT REPEAT 3537..3577
FT /note="LDL-receptor class B 26"
FT DOMAIN 3582..3624
FT /note="EGF-like 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 3625..3668
FT /note="LDL-receptor class A 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3669..3707
FT /note="LDL-receptor class A 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3707..3748
FT /note="LDL-receptor class A 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3751..3790
FT /note="LDL-receptor class A 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3791..3832
FT /note="LDL-receptor class A 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3831..3873
FT /note="LDL-receptor class A 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3876..3914
FT /note="LDL-receptor class A 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3915..3953
FT /note="LDL-receptor class A 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3957..3997
FT /note="LDL-receptor class A 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3998..4042
FT /note="LDL-receptor class A 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4047..4085
FT /note="LDL-receptor class A 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4088..4131
FT /note="EGF-like 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4132..4176
FT /note="EGF-like 15; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REPEAT 4227..4276
FT /note="LDL-receptor class B 27"
FT REPEAT 4343..4386
FT /note="LDL-receptor class B 28"
FT REPEAT 4388..4429
FT /note="LDL-receptor class B 29"
FT REPEAT 4430..4470
FT /note="LDL-receptor class B 30"
FT DOMAIN 4477..4515
FT /note="EGF-like 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 4526..4554
FT /note="EGF-like 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT REGION 4661..4753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 4653..4658
FT /note="Endocytosis signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 4667..4697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4724..4742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 4744
FT /note="Critical for endocytosis"
FT /evidence="ECO:0000250"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754521,
FT ECO:0000269|PubMed:17761667"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 380
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 887
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1039
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1057
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15888633"
FT CARBOHYD 1184
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1431
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 1542
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 1545
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 1597
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15888633,
FT ECO:0000269|PubMed:17761667"
FT CARBOHYD 1718
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15888633,
FT ECO:0000269|PubMed:17761667"
FT CARBOHYD 1871
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2364
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 2501
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2762
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 2888
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2996
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3046
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3557
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 3626
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3682
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3752
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 4063
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 4139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 4248
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:15888633"
FT DISULFID 53..65
FT /evidence="ECO:0000250"
FT DISULFID 60..78
FT /evidence="ECO:0000250"
FT DISULFID 72..87
FT /evidence="ECO:0000250"
FT DISULFID 92..109
FT /evidence="ECO:0000250"
FT DISULFID 99..122
FT /evidence="ECO:0000250"
FT DISULFID 116..131
FT /evidence="ECO:0000250"
FT DISULFID 138..152
FT /evidence="ECO:0000250"
FT DISULFID 146..165
FT /evidence="ECO:0000250"
FT DISULFID 159..175
FT /evidence="ECO:0000250"
FT DISULFID 182..195
FT /evidence="ECO:0000250"
FT DISULFID 189..208
FT /evidence="ECO:0000250"
FT DISULFID 202..218
FT /evidence="ECO:0000250"
FT DISULFID 223..235
FT /evidence="ECO:0000250"
FT DISULFID 230..248
FT /evidence="ECO:0000250"
FT DISULFID 242..257
FT /evidence="ECO:0000250"
FT DISULFID 262..275
FT /evidence="ECO:0000250"
FT DISULFID 269..288
FT /evidence="ECO:0000250"
FT DISULFID 282..297
FT /evidence="ECO:0000250"
FT DISULFID 302..311
FT /evidence="ECO:0000250"
FT DISULFID 307..320
FT /evidence="ECO:0000250"
FT DISULFID 322..336
FT /evidence="ECO:0000250"
FT DISULFID 342..352
FT /evidence="ECO:0000250"
FT DISULFID 348..361
FT /evidence="ECO:0000250"
FT DISULFID 363..367
FT /evidence="ECO:0000250"
FT DISULFID 673..682
FT /evidence="ECO:0000250"
FT DISULFID 678..697
FT /evidence="ECO:0000250"
FT DISULFID 699..711
FT /evidence="ECO:0000250"
FT DISULFID 1001..1010
FT /evidence="ECO:0000250"
FT DISULFID 1006..1026
FT /evidence="ECO:0000250"
FT DISULFID 1028..1042
FT /evidence="ECO:0000250"
FT DISULFID 1054..1068
FT /evidence="ECO:0000250"
FT DISULFID 1063..1081
FT /evidence="ECO:0000250"
FT DISULFID 1075..1095
FT /evidence="ECO:0000250"
FT DISULFID 1101..1114
FT /evidence="ECO:0000250"
FT DISULFID 1108..1127
FT /evidence="ECO:0000250"
FT DISULFID 1121..1138
FT /evidence="ECO:0000250"
FT DISULFID 1146..1158
FT /evidence="ECO:0000250"
FT DISULFID 1153..1171
FT /evidence="ECO:0000250"
FT DISULFID 1165..1182
FT /evidence="ECO:0000250"
FT DISULFID 1187..1199
FT /evidence="ECO:0000250"
FT DISULFID 1194..1212
FT /evidence="ECO:0000250"
FT DISULFID 1206..1223
FT /evidence="ECO:0000250"
FT DISULFID 1228..1241
FT /evidence="ECO:0000250"
FT DISULFID 1235..1254
FT /evidence="ECO:0000250"
FT DISULFID 1248..1263
FT /evidence="ECO:0000250"
FT DISULFID 1270..1283
FT /evidence="ECO:0000250"
FT DISULFID 1277..1296
FT /evidence="ECO:0000250"
FT DISULFID 1290..1307
FT /evidence="ECO:0000250"
FT DISULFID 1313..1325
FT /evidence="ECO:0000250"
FT DISULFID 1320..1338
FT /evidence="ECO:0000250"
FT DISULFID 1332..1350
FT /evidence="ECO:0000250"
FT DISULFID 1359..1373
FT /evidence="ECO:0000250"
FT DISULFID 1366..1386
FT /evidence="ECO:0000250"
FT DISULFID 1380..1396
FT /evidence="ECO:0000250"
FT DISULFID 1401..1412
FT /evidence="ECO:0000250"
FT DISULFID 1408..1421
FT /evidence="ECO:0000250"
FT DISULFID 1423..1435
FT /evidence="ECO:0000250"
FT DISULFID 1441..1451
FT /evidence="ECO:0000250"
FT DISULFID 1447..1460
FT /evidence="ECO:0000250"
FT DISULFID 1462..1475
FT /evidence="ECO:0000250"
FT DISULFID 1751..1760
FT /evidence="ECO:0000250"
FT DISULFID 1756..1770
FT /evidence="ECO:0000250"
FT DISULFID 1772..1785
FT /evidence="ECO:0000250"
FT DISULFID 2084..2095
FT /evidence="ECO:0000250"
FT DISULFID 2091..2105
FT /evidence="ECO:0000250"
FT DISULFID 2107..2119
FT /evidence="ECO:0000250"
FT DISULFID 2400..2415
FT /evidence="ECO:0000250"
FT DISULFID 2411..2426
FT /evidence="ECO:0000250"
FT DISULFID 2428..2438
FT /evidence="ECO:0000250"
FT DISULFID 2732..2743
FT /evidence="ECO:0000250"
FT DISULFID 2739..2759
FT /evidence="ECO:0000250"
FT DISULFID 2761..2779
FT /evidence="ECO:0000250"
FT DISULFID 2792..2805
FT /evidence="ECO:0000250"
FT DISULFID 2800..2818
FT /evidence="ECO:0000250"
FT DISULFID 2812..2829
FT /evidence="ECO:0000250"
FT DISULFID 2834..2846
FT /evidence="ECO:0000250"
FT DISULFID 2841..2859
FT /evidence="ECO:0000250"
FT DISULFID 2853..2868
FT /evidence="ECO:0000250"
FT DISULFID 2874..2886
FT /evidence="ECO:0000250"
FT DISULFID 2881..2899
FT /evidence="ECO:0000250"
FT DISULFID 2893..2912
FT /evidence="ECO:0000250"
FT DISULFID 2919..2932
FT /evidence="ECO:0000250"
FT DISULFID 2926..2945
FT /evidence="ECO:0000250"
FT DISULFID 2939..2956
FT /evidence="ECO:0000250"
FT DISULFID 2961..2973
FT /evidence="ECO:0000250"
FT DISULFID 2968..2986
FT /evidence="ECO:0000250"
FT DISULFID 2980..2997
FT /evidence="ECO:0000250"
FT DISULFID 3006..3019
FT /evidence="ECO:0000250"
FT DISULFID 3014..3032
FT /evidence="ECO:0000250"
FT DISULFID 3026..3044
FT /evidence="ECO:0000250"
FT DISULFID 3049..3069
FT /evidence="ECO:0000250"
FT DISULFID 3056..3082
FT /evidence="ECO:0000250"
FT DISULFID 3076..3093
FT /evidence="ECO:0000250"
FT DISULFID 3100..3112
FT /evidence="ECO:0000250"
FT DISULFID 3107..3125
FT /evidence="ECO:0000250"
FT DISULFID 3119..3135
FT /evidence="ECO:0000250"
FT DISULFID 3140..3152
FT /evidence="ECO:0000250"
FT DISULFID 3147..3165
FT /evidence="ECO:0000250"
FT DISULFID 3159..3174
FT /evidence="ECO:0000250"
FT DISULFID 3187..3199
FT /evidence="ECO:0000250"
FT DISULFID 3194..3212
FT /evidence="ECO:0000250"
FT DISULFID 3206..3222
FT /evidence="ECO:0000250"
FT DISULFID 3227..3239
FT /evidence="ECO:0000250"
FT DISULFID 3235..3248
FT /evidence="ECO:0000250"
FT DISULFID 3250..3264
FT /evidence="ECO:0000250"
FT DISULFID 3270..3281
FT /evidence="ECO:0000250"
FT DISULFID 3277..3290
FT /evidence="ECO:0000250"
FT DISULFID 3292..3305
FT /evidence="ECO:0000250"
FT DISULFID 3586..3597
FT /evidence="ECO:0000250"
FT DISULFID 3593..3608
FT /evidence="ECO:0000250"
FT DISULFID 3610..3623
FT /evidence="ECO:0000250"
FT DISULFID 3627..3641
FT /evidence="ECO:0000250"
FT DISULFID 3634..3654
FT /evidence="ECO:0000250"
FT DISULFID 3648..3666
FT /evidence="ECO:0000250"
FT DISULFID 3671..3683
FT /evidence="ECO:0000250"
FT DISULFID 3678..3696
FT /evidence="ECO:0000250"
FT DISULFID 3690..3705
FT /evidence="ECO:0000250"
FT DISULFID 3709..3722
FT /evidence="ECO:0000250"
FT DISULFID 3716..3735
FT /evidence="ECO:0000250"
FT DISULFID 3729..3746
FT /evidence="ECO:0000250"
FT DISULFID 3753..3765
FT /evidence="ECO:0000250"
FT DISULFID 3760..3778
FT /evidence="ECO:0000250"
FT DISULFID 3772..3788
FT /evidence="ECO:0000250"
FT DISULFID 3793..3806
FT /evidence="ECO:0000250"
FT DISULFID 3800..3819
FT /evidence="ECO:0000250"
FT DISULFID 3813..3830
FT /evidence="ECO:0000250"
FT DISULFID 3833..3847
FT /evidence="ECO:0000250"
FT DISULFID 3841..3860
FT /evidence="ECO:0000250"
FT DISULFID 3854..3871
FT /evidence="ECO:0000250"
FT DISULFID 3878..3890
FT /evidence="ECO:0000250"
FT DISULFID 3885..3903
FT /evidence="ECO:0000250"
FT DISULFID 3897..3912
FT /evidence="ECO:0000250"
FT DISULFID 3917..3929
FT /evidence="ECO:0000250"
FT DISULFID 3924..3942
FT /evidence="ECO:0000250"
FT DISULFID 3936..3951
FT /evidence="ECO:0000250"
FT DISULFID 3959..3971
FT /evidence="ECO:0000250"
FT DISULFID 3966..3984
FT /evidence="ECO:0000250"
FT DISULFID 3978..3995
FT /evidence="ECO:0000250"
FT DISULFID 4000..4014
FT /evidence="ECO:0000250"
FT DISULFID 4008..4027
FT /evidence="ECO:0000250"
FT DISULFID 4021..4040
FT /evidence="ECO:0000250"
FT DISULFID 4049..4061
FT /evidence="ECO:0000250"
FT DISULFID 4056..4074
FT /evidence="ECO:0000250"
FT DISULFID 4068..4083
FT /evidence="ECO:0000250"
FT DISULFID 4092..4105
FT /evidence="ECO:0000250"
FT DISULFID 4101..4114
FT /evidence="ECO:0000250"
FT DISULFID 4116..4130
FT /evidence="ECO:0000250"
FT DISULFID 4136..4146
FT /evidence="ECO:0000250"
FT DISULFID 4142..4155
FT /evidence="ECO:0000250"
FT DISULFID 4157..4175
FT /evidence="ECO:0000250"
FT DISULFID 4481..4490
FT /evidence="ECO:0000250"
FT DISULFID 4486..4500
FT /evidence="ECO:0000250"
FT DISULFID 4502..4514
FT /evidence="ECO:0000250"
FT DISULFID 4528..4536
FT /evidence="ECO:0000250"
FT DISULFID 4530..4542
FT /evidence="ECO:0000250"
FT DISULFID 4544..4553
FT /evidence="ECO:0000250"
SQ SEQUENCE 4753 AA; 526425 MW; CCFC40E397B8D4FC CRC64;
MILRLLIFTA LAVTTANSST RQQSTFHSIQ VDSPPSVRSR IISASVNTAS SVCNENDFRC
NDGKCIRTEW KCDGSGDCSD GEDEKDCPHP GCKSDQWQCD TYTWHSVSCI AEYQRCDNIT
DCADGSDEKD CPASTVDCSS QNVFMCADGR QCFDVSKKCD GKYDCRDLSD EKDSCSRNHT
ACFQYQFRCA DKTQCIQKSW VCDGSKDCAD GSDEPDTCEF KKCTANEFQC KNKRCQPRKF
RCDYYDDCGD NSDEDECGEY RCPPGKWNCP GTGHCIDQLK LCDGSKDCAD GADEQQCSQN
LCPSLGCQAG CHPSPHGGEC TCPSGYKLDD RFHRTCSDIN ECAEFGYCDQ LCANHRPGFT
CSCLGDCFTL QMEHGPGKDN LTMRGYCVSN NADKMKLFVA RREGLYRLNP KNPDEEVKKL
ASGEFIYGID FDYGDRKIFW TDRLAHSAFS ADVDDEGEIS QIKKLSLKSL VYPRCLAVDW
ITNTLYIIES GSRRIDVSSY DGERRTVLLA DGLTLPLDIA LDPLRGEMFF TNQLKLEAAA
MDGTNRRTLV NTHTHQVSGI VVDITAKRVY WVDPKVDRLE SIDYQGNDRR IVAQGMNVVP
HPFGLALFDQ YLYWTDWTRL GVIQVEKFGS DTKLLWSNTE NNVFPMGISA YHPMAQPGPG
QSECLAMKIE NPCTNADCEG MCILSKDNGG FGVGYKCACP IGQKLVNGKR CIDSIDYLLF
SSNKIVRGIF PEINEKALAE AVLPISPISQ RRIGMYFEVE CDVHGNSFFY ADIMDNTIYR
IRPDGEGAAP VLVTHNDGLF SMSFDWISKQ LYYVDNIRNS LEVVKIGETG LVHPDELVRR
QLITELRDPV SVVVHPWKGL LFYAEAMRPA AIYRCHIDGQ NCQVIRNTTL GRPSEMAIDF
AENRLCWGDT LLKTISCMDF DGKNVVKLDI DNPIPVAITI MNEYIYYVHQ RPYSIRRVHK
KNGGGSKIVR EFGADERSIF SLKACSHQNQ PIPDDSREHP CRASQCTQLC FATPSESHPN
ELEAKCACRQ GFMINKENNH SCQKDPAEKI EQLCSSNSTQ FQCKNGRCIP KEWKCDGEND
CLDESDEIDE KGDKCFHETE CAENTIKCRN TKKCIPAQYG CDGDNDCGDY SDEDVKYCKD
GQKPVCAAKK FQCDNHRCIP EQWKCDSDND CGDGSDEKLE MCGNATCAAN QFSCANGRCI
PIYWLCDGDN DCYDGTDEDK ERCPPVQCSA LQFRCANGRQ CVPLRNHCDG QSDCEDGSDE
DSCAVTAESC TPDQFKCVSS GLCIPASWKC DGQQDCDDGS DEPKFGCTSG RQCSSDQFKC
GNGRCILNNW LCDGENDCGD GSDESSERGC KTSMNARKCP FEHVACENDQ ETCIPLHQLC
DGKTHCPGGT DEGGRCARDL CSADRAGCSF KCHNSPNGPI CSCPFGEQLV NKTKCEPENE
CLDSSSCSQR CKDEKHGFTC SCDEGYELDV DKRTCKVADN VKDTRIYVSN RNRIYYSDHK
LDNWHTFGAI VENAIALAWD SLTDRIYWSD IREKKILSAN RNGTNATVFI ADGLDITEGI
ALDWVGRNLY WVDSSLNTIE VANLEDPKQR TLLVHQNVSQ PRGIAVDPRK GVMFWTDWGQ
NPCIERASMD GTDRQIIVKT KIYWPNTIAL DYTTDRVYFA DSKLDFIDFV NYDGSGRTQV
LASSKFVQHP HALAIFEDMM YYSDRRLQKL QVYPKYPNGT TSEYPSHTFS KALGVVAVHP
VLQPVIKNNP CSTNPCSHLC LLNNKNTFTC KCPMGEKLDA SGKKCIDDAK PFLVIIQKTN
VFGIEMNSAS EKETPVLAGM VPLSGLGNAF DAAYDALSEE MFILEHTNHA KTLAQITTDS
AIYRSTVNGG NKTKMFSSAV PDDAYCLGFD WNGRNLVVGN KITQTIEIIR TQGKQYRSVI
LSNDQSPTAV VTPVAIAVDA DKGYVFWLDR GGGAADAKVA RAGLDGSNPL VIASNDLAEL
DHIAIDTTNT RVYFSEAKAG RISSVTYDGQ DRHYVLSDGG RQPNGLAFYG DRLFYADSAF
DSIEVATING DSQPPQWTHF KKDVENLANI KALQPRASSS GHPCHINNGN CDHICIPLMF
AQRTCTCANG YVKDGQTSCK LFDESFVIVA TKTKVIGYPI DETQSKGVAM EPIGGLSITG
VDYDYESKTI YVAEASGINK GITAYTIGES SPRAVIRDSI GSLTIKSLAI DWINYNMYFI
NHDAERTNIE VSKLDGTYRK ILLTTKTETP SSIAVDPVSR YLYWADQGQK PTIQRSFLDG
SRREVIVSSG IAEPTDLVVD VASKMIYWSD AKMDGIYRVR STGGTPELVR SDIASAAGVA
LHGQNMYWTD NRLEKLFRAT SKPNQTSLLL SPTTVAASLK DIGDVAVFSS NNQPRASSPC
QITDNLRKSP CTQLCFATPG TQTPTCSCAR GVLKGRTCEE PDTYIMFSDG DKIIDVAIEP
DVKASRPLKD PFPEISNLQT FDVDVNLRRV YFVVESPVGV NISWFSMNNA ENPRLVFGAS
KQPHAKEIRH ISDMKLDWLT QKIYFTTGRG GKVMAIDTAG EHLSTIASGD WTYALAIDPC
SGLLFWSDSG YKTSGGLYEP RIERSNLAGG SRKVIVSESI SLPAAIAVDF RNQKIYWADV
NRLNIEVADY DGQNRKVIAS GYRAKSLDIW DRWLYMSDPL SNGVFRIDKE SGSGLENVVS
DRRIPGALRV FASESDVRTR NQVCNALTSQ LCKTDNGGCD QLCTVVADDI GLAASKVQCS
CNDTYELVQE PGKDYPTQCV LRGSNSEPAK ECLPPYNFQC GDGSCILLGA TCDSKPDCAD
ASDENPNYCN TRSCPEDYNL CTNRRCIDSA KKCNHIDDCG DGSDELDCPS AVACAEGTFP
CSNGHCINQT KVCDGHNDCH DEQVSDESLA TCPGLPIDCR GVKVRCPNTN ICIQPADLCD
GYDDCGDKAD ENQLFCMNQQ CAQHYVRCPS GRCIPETWQC DGDNDCSDGW DETHTNCTDT
AGKKICVGDY LFQCDNLKCI SRAFICDGED DCGDGSDEHS RHGCGNRTCT DQEFHCTSNA
KLAQPKYECI PRAWLCDGDV TCAGGEDEST ELCKTEKKEC NKGEFRCSNQ HCIHSTWECD
GDNDCLDGSD EHANCTYSSC QPDFFQCANH KCVPNSWKCD GNDDCEDGSD EKDCPKNSAS
AQKASKCSNG QFQCTSGECI DDAKVCDRNF DCTDRSDESS LCFIDECSLA EKPLCEQKCM
DMKIGYKCDC FEGFAIDISD QKSCHNVNEC YEGISGCSQK CDDKIGSYKC GCVDGYQLSS
DDHSCKRTEM EPEPFFLLAN KHYIRKISID GNKYELAAQG FDNVVSLDID LTEKKAYLID
QGKLRLLRVD LDEMDSPLSS YETVLRHNVY GTEGIAVDWV GRKLYMLNRQ ERSIRVCELD
GRFCKTLIRD RIQQPKAIVV HPGKGYLFFT EWSLQPYIGR IALDGSPELQ DPIFKLAEHD
LGWPNAIAID YFSDRLFWGD AHLNEIGFMD FDGNGRRHIP AQRTSHVSSM VVFDDYLYWA
DWNLREVLRC DKWTGKNETI LKKTVQLPND LRIVHPMRQP AYPNPCGDNN GGCSHLCLIG
AGGNGYTCSC PDQFVLLSDQ KTCEPNCTER QFACGGDDAK CIPKLWYCDG EPDCRDGSDE
PGESICGQRI CPVGEFQCTN HNCTRPFQIC DGNDDCGDSS DEQNCDKACD PWMFKCAATG
RCIPRRFTCD GDDDCGDRSD EADTLCMSAE RNCTAEEFRC NNNKCIAKAW RCDNDDDCGD
GSDETPECAQ IECKKGWTRC SSSYRCIPNW AFCNGQDDCR DNSDEDKQRC PTCDDVGEFR
CATSGKCIPR RWMCDTENDC GDNSDELDAS CGGTTRPCSE SEFRCNDGKC IPGSKVCDGT
IQCSDGLDES QCTLRRCLPG HRQCDDGTCI AEHKWCDRKK DCPNAADELH CEDVSRRTCS
PFEFECANSV CIPRKFMCDG DNDCGDNSDE TSSECRSAQC DPPLRFRCAH SRLCLNILQL
CNGFNDCGPN DFSDEHLSMC SSFSEYGDCS SDQFKCANGK CVNGTVACDR KDDCGDASDE
IGCSKHGGKT SCEAFGNNGG CKHICTDVRD GFYCHCRDGF RPDPQSPKEC IDIDECAGNN
TCTQLCLNTK GSYLCRCHED YENNVVVGSM TGKDCRAKGD AANVMIGADD SLVQLSLHGS
GTNRHAAAKA NDDDNDIIGI AFDPRKELMY WIDGSERTIY RSAIANGNQS HEGQKLDVDF
AAMGVVPTAI AVDYTTGNLF IAAVSENIEN GLVTARKKRM SEPIDNQNTG FIFVCLPDGR
YLKKIVAGHL QQPTALITAP SAGRICYSDA GLHAKIECAD MDGTHRQIIV KDLVFSPTSM
AIDEGKGNRI YWVDPKYRRV DAVNIDGSER TTVVHDRHIP YAVDVFENHI YWLSRESKTL
YVQDKFGRGR VSVLASDLED GHTVRVSQKY AKDTQRTVSG CERAQCSHLC VSLPSTGFAC
LCPDGIVPQL DGSCATQHVE ALTMPKQCKC TNGGKCRLDG SCECTSDFEG DQCEKESSVS
RKIIGTLSEN FITVLLYILA FLFAFGLIGF CALNLYKRRQ LLFKKNEAAD GSVSFHGNVI
SFSNPVLENK QDAPGSEFNM QQMTSMHDDS TTFTNPVYEL EDVDMSSPPP SNDQPSTSAS
AMSPNRPSTS AASSFVPPTF DQDEIELKTA DEIIVPKAEI SKPPIPARPK KEKADPLRVD
NPLYDPDSEV SDV
