ID   LRP_HALS3               Reviewed;         154 AA.
AC   B0R717;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=HTH-type transcriptional regulator Lrp;
GN   Name=lrp; OrderedLocusNames=OE_3923F;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
RN   [2]
RP   FUNCTION.
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=20509863; DOI=10.1186/1471-2199-11-40;
RA   Schwaiger R., Schwarz C., Furtwangler K., Tarasov V., Wende A.,
RA   Oesterhelt D.;
RT   "Transcriptional control by two leucine-responsive regulatory proteins in
RT   Halobacterium salinarum R1.";
RL   BMC Mol. Biol. 11:40-40(2010).
CC   -!- FUNCTION: Transcription factor that regulates multiple target genes,
CC       including those encoding enzymes involved in amino acid synthesis,
CC       central metabolism, transport processes and other regulators of
CC       transcription. Acts as both an activator and a repressor of
CC       transcription. {ECO:0000269|PubMed:20509863}.
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DR   EMBL; AM774415; CAP14536.1; -; Genomic_DNA.
DR   RefSeq; WP_010903541.1; NC_010364.1.
DR   AlphaFoldDB; B0R717; -.
DR   SMR; B0R717; -.
DR   EnsemblBacteria; CAP14536; CAP14536; OE_3923F.
DR   GeneID; 5953792; -.
DR   GeneID; 62887400; -.
DR   KEGG; hsl:OE_3923F; -.
DR   HOGENOM; CLU_091233_5_4_2; -.
DR   OMA; HVSGDYD; -.
DR   PhylomeDB; B0R717; -.
DR   PRO; PR:B0R717; -.
DR   Proteomes; UP000001321; Chromosome.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..154
FT                   /note="HTH-type transcriptional regulator Lrp"
FT                   /id="PRO_0000428914"
FT   DOMAIN          3..64
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
SQ   SEQUENCE   154 AA;  16715 MW;  16B7194C2909F2A9 CRC64;
     MTYENLDVKL VNELLGDGRA SLRSLADDLD VSVTTVSNHL QTLEDEGAVN GYTPVVDYER
     LGYDVTAILQ LKVDGTALPE ITGTLRGHKQ MVSVYEITGD YDVLAIGKFT DTDDMNTLIK
     ELLADADINE SSTSVVLNAA AENEQFELDL DGDA