ID   LRP_KLEAE               Reviewed;         164 AA.
AC   P0ACJ4; O87635; P0A2S1; P19494; P37403;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Leucine-responsive regulatory protein;
GN   Name=lrp;
OS   Klebsiella aerogenes (Enterobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7883720; DOI=10.1128/jb.177.6.1624-1626.1995;
RA   Friedberg D., Platko J.V., Tyler B., Calvo J.M.;
RT   "The amino acid sequence of Lrp is highly conserved in four enteric
RT   microorganisms.";
RL   J. Bacteriol. 177:1624-1626(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=W70;
RX   PubMed=9922277; DOI=10.1128/jb.181.3.1054-1058.1999;
RA   Janes B.K., Bender R.A.;
RT   "Two roles for the leucine-responsive regulatory protein in expression of
RT   the alanine catabolic operon (dadAB) in Klebsiella aerogenes.";
RL   J. Bacteriol. 181:1054-1058(1999).
CC   -!- FUNCTION: Mediates a global response to leucine. Exogenous leucine
CC       affects the expression of a number of different operons; lrp mediates
CC       this effect for at least some of these operons. For example it is
CC       regulator of the branched-chain amino acid transport genes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U02272; AAA75439.1; -; Genomic_DNA.
DR   EMBL; AF090144; AAD12584.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0ACJ4; -.
DR   SMR; P0ACJ4; -.
DR   STRING; 548.EAG7_02473; -.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
DR   PROSITE; PS00519; HTH_ASNC_1; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..164
FT                   /note="Leucine-responsive regulatory protein"
FT                   /id="PRO_0000111727"
FT   DOMAIN          12..73
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   DNA_BIND        31..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   CONFLICT        95
FT                   /note="T -> A (in Ref. 2; AAD12584)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   164 AA;  18887 MW;  2952FB9347A2725C CRC64;
     MVDSKKRPGK DLDRIDRNIL NELQKDGRIS NVELSKRVGL SPTPCLERVR RLERQGFIQG
     YTALLNPHYL DASLLVFVEI TLNRGAPDVF EQFNTAVQKL EEIQECHLVS GDFDYLLKTR
     VPDMSAYRKL LGETLLRLPG VNDTRTYVVM EEVKQSNRLV IKTR