LRP_SALTY
ID LRP_SALTY Reviewed; 164 AA.
AC P0A2S0; O87635; P37403;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Leucine-responsive regulatory protein;
GN Name=lrp; OrderedLocusNames=STM0959;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7883720; DOI=10.1128/jb.177.6.1624-1626.1995;
RA Friedberg D., Platko J.V., Tyler B., Calvo J.M.;
RT "The amino acid sequence of Lrp is highly conserved in four enteric
RT microorganisms.";
RL J. Bacteriol. 177:1624-1626(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Mediates a global response to leucine. Exogenous leucine
CC affects the expression of a number of different operons; lrp mediates
CC this effect for at least some of these operons. For example it is
CC regulator of the branched-chain amino acid transport genes.
CC -!- SUBUNIT: Homodimer.
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DR EMBL; U02273; AAA75467.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL19894.1; -; Genomic_DNA.
DR PIR; S59993; S59993.
DR RefSeq; NP_459935.1; NC_003197.2.
DR RefSeq; WP_000228469.1; NC_003197.2.
DR AlphaFoldDB; P0A2S0; -.
DR BMRB; P0A2S0; -.
DR SMR; P0A2S0; -.
DR STRING; 99287.STM0959; -.
DR PaxDb; P0A2S0; -.
DR PRIDE; P0A2S0; -.
DR EnsemblBacteria; AAL19894; AAL19894; STM0959.
DR GeneID; 1252478; -.
DR GeneID; 64296168; -.
DR GeneID; 67462861; -.
DR KEGG; stm:STM0959; -.
DR PATRIC; fig|99287.12.peg.1011; -.
DR HOGENOM; CLU_091233_0_0_6; -.
DR OMA; AGDENYI; -.
DR PhylomeDB; P0A2S0; -.
DR BioCyc; SENT99287:STM0959-MON; -.
DR PRO; PR:P0A2S0; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006524; P:alanine catabolic process; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR GO; GO:0043200; P:response to amino acid; IBA:GO_Central.
DR GO; GO:0043201; P:response to leucine; IBA:GO_Central.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01037; AsnC_trans_reg; 1.
DR PRINTS; PR00033; HTHASNC.
DR SMART; SM00344; HTH_ASNC; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF54909; SSF54909; 1.
DR PROSITE; PS00519; HTH_ASNC_1; 1.
DR PROSITE; PS50956; HTH_ASNC_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..164
FT /note="Leucine-responsive regulatory protein"
FT /id="PRO_0000111735"
FT DOMAIN 12..73
FT /note="HTH asnC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT CONFLICT 86
FT /note="A -> G (in Ref. 1; AAA75467)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 164 AA; 18857 MW; 3943FA9347BE1E2C CRC64;
MVDSKKRPGK DLDRIDRNIL NELQKDGRIS NVELSKRVGL SPTPCLERVR RLERQGFIQG
YTALLNPHYL DASLLVFVEI TLNRGAPDVF EQFNAAVQKL EEIQECHLVS GDFDYLLKTR
VPDMSAYRKL LGETLLRLPG VNDTRTYVVM EEVKQSNRLV IKTR
