LRR4_PLAF7
ID LRR4_PLAF7 Reviewed; 3394 AA.
AC O77384;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 23-FEB-2022, entry version 84.
DE RecName: Full=Protein PFC0760c;
GN ORFNames=PFC0760c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=10448855; DOI=10.1038/22964;
RA Bowman S., Lawson D., Basham D., Brown D., Chillingworth T., Churcher C.M.,
RA Craig A., Davies R.M., Devlin K., Feltwell T., Gentles S., Gwilliam R.,
RA Hamlin N., Harris D., Holroyd S., Hornsby T., Horrocks P., Jagels K.,
RA Jassal B., Kyes S., McLean J., Moule S., Mungall K.L., Murphy L.,
RA Oliver K., Quail M.A., Rajandream M.A., Rutter S., Skelton J., Squares R.,
RA Squares S., Sulston J.E., Whitehead S., Woodward J.R., Newbold C.,
RA Barrell B.G.;
RT "The complete nucleotide sequence of chromosome 3 of Plasmodium
RT falciparum.";
RL Nature 400:532-538(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [4] {ECO:0000305}
RP SYNTHESIS OF 2208-2236 AND 2401-2429, AND POSSIBLE CANDIDATE MALARIA
RP EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; AL844502; CAB11140.1; -; Genomic_DNA.
DR PIR; T18501; T18501.
DR RefSeq; XP_001351243.1; XM_001351207.1.
DR SMR; O77384; -.
DR BioGRID; 1209731; 16.
DR IntAct; O77384; 13.
DR STRING; 5833.PFC0760c; -.
DR PRIDE; O77384; -.
DR EnsemblProtists; CAB11140; CAB11140; PF3D7_0317300.
DR GeneID; 814487; -.
DR KEGG; pfa:PF3D7_0317300; -.
DR VEuPathDB; PlasmoDB:PF3D7_0317300; -.
DR HOGENOM; CLU_224997_0_0_1; -.
DR InParanoid; O77384; -.
DR OMA; WPVNSRR; -.
DR PhylomeDB; O77384; -.
DR Proteomes; UP000001450; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0016540; P:protein autoprocessing; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Merozoite; Reference proteome; Repeat.
FT CHAIN 1..3394
FT /note="Protein PFC0760c"
FT /id="PRO_0000388754"
FT REGION 471..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1892..1918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2648..2693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2835..2909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3000..3057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3107..3394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2654..2672
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2673..2693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2855..2909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3008..3049
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3147..3262
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3263..3286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3287..3330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3331..3380
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3394 AA; 402952 MW; 81BB86F2056A4B57 CRC64;
MNNDFMKNEK DDYDKVNEEE YSLENFRGID MNNNVDISNM NNNLNDVGEL INIDNNDKYD
EDQLSLIKES LEYGELLLSN VKEEDENNRR EHFKKNDYMK DTEDVHYKES KIGQDKRFMH
SLCVKELKST EEGELFDDEK YKDKDTLINM LRKKLEIKIK DYNLIMDTLI LTKEECSKKE
EQLKDYKMKY NKMEKECYSL KNEIERKNNE KHLNIGSFSF YKNEYDDMKY KLLKCEEKNK
ILLNKNQELH QTIIQMKNDS YNQNIKFKKD IDVLTEDKKN ILIQNKNFTK QNKILIDKYL
RQEKIIYKLK KHNEEQEIII KECHKKIEFV NKNSVNHLNK VRDVLNKSLI KSEEHVKLYT
NLKKENDSLK IEYNKSKTNI QQLNEQLVNY KNFIKEMEKK YKQLVVKNNS LFSITHDFIN
LKNSNIIIIR RTSDMKQIFK MYNLDIEHFN EQDHLSVIYI YEILYNTNDN NNNDNDNNND
NNNNNNNNND NNNNNNNDNN NNNNNYNNIM MMIENMNSGN HPNSNNLHNY RHNTNDENNL
SSLKTSFRYK INNKSGKSRS IKSRSHFSGD NEYIQDQLSN REMKDHYNYI ERYNHSSNRN
DIHNLYYMEE NVSHNNNKSD YDEDGDAENN NYYIKIKKNK YKKLNDLLNK AQMKIITLTR
ANEMFEKYCS NIKNTLIRDD MKKFRKPDIS DVHILHNEKI YLEKLLNEKL NYIKDIEKKL
DELHGVINKN KEDIYILQVE KQTLIKVISS VYDYTKMESE NHIFKMNTTW NKMLNNVHMS
SNKDYNNQNN QNIENNQNIE NNQNNQNIEN NQNIENNQNN QNNQNNQNNQ NNQNNQNNQN
NAGIHISPDD FLKYRMSLEK FIQFTIKEHI VYIMKDEKKK TSNIIKESIS LKKKHTKKSI
INNNNDNNNE DDDDNDMLSV MYSNDDVIKN KRKENNKEIL EEHVSFSSFS NNEYIAHSFN
SILLQLSNYI FNIECKQMEY FKNSNLLSYV DDYTITIELF YRLKKYNNIF SIEQILGTQY
PSILQKLHDG IYCLKDNNKK KNNDGDNKSQ EDDDGNKKKN NDGDNKSQED DDGNKKKNND
GDNKSQEDDY GNKKKNNDDD DDDSYKIELI VDELNKCKKN YTDEELYELM KGSDFDIFKK
YKNFYLNHFI NINNIFSTII SFHIHNIEDK YKKVYERYFN LFNFNFSNVE LSFDLLIRRF
DKILRLTKKY EQLLEENYEK IKNKNEKEEY LHACIKELEM NLERYNNEKI ILDEQINEKE
KKINIINEKY LILEKEYEEY QNKNIFINAQ IENLEKEKKQ LQEEIIQKDM INVKLNEKNC
DIIKIYEKEK QYLHTLLQEN KDSHNYLKDK FENLLNLNEK LKYDHDISLN KINTLWLEEK
ENNKKNTFHM NNLRVENNNL LLKMKELQNK YNIIKKELNE RIKQINVFRN NVSTLSLRDN
RSTRGSIHQI NNMYMNNTHL GFMGASKINN NISNLYYSNM IHMSHRGSII KNKEDAEGNS
TQARMNNKDS TDNIINNIHN TDNINNMNNI NNNTLNSINS NHLYYPFPFH NNVNSPKMVG
MCDVTLASGV NKKDDFLLNL EENEENSFLE YEIRIKSLQE ELCDKESEIL KIKGEKNILI
TCIETWKCFC KNSKEEISRL KEICKEQLEK HKEFLLINKS NEDKLKYINS LLCDEKDKYD
IVVKDIKNNM RNEIDKLNND INEKSYEIKL LKHENNNLIN EMNILKNKET ENMNIKQKEE
DYIKLIKKDK TNIQNEYNDL LEKYNEVVVK NNMLYNDMNV LLKEHKEEIF LLKENIKILQ
KDNTYLNDMF KNQINYVDNN LLKNRLDQLF NINQDLQKHL DTNQKHLEQL KYDYIEIKER
LKIEKTKINK QEKYIIQLQK DNNLILNDFN STTTTTNNNN NNDNNNDNNN DNNDNNNDTY
QQFIHSLKAN LENSRLELKE LSNLNEKIQL SDEKNRMKIT ILEDKLFKNE KDKMKLQQII
DDNNKNYMIQ YNKLKTNLDM LSEENRMLLL NKEEYEKQIE QLNHDHKLFI STKNNDIQII
ENEKLQEQVD QYITTINEKD KIIVHLNLQI KKLANQNEHM RSRCDIFNVA HSQDNIKNDH
MVVGEDIMGD TNHDVNKNID QGTNQHINQG TNQHINQGTN QHDTCDGPNY NYVKVQNATN
REDNKNKERN LSQEIYKYIN ENIDLTSELE KKNDMLENYK NELKEKNEEI YKLNNDIDML
SNNCKKLKES IMMMEKYKII MNNNIQEKDE IIENLKNKYN NKLDDLINNY SVVDKSIVSC
FEDSNIMSPS CNDILNVFNN LSKSNKKVCT NMDICNENMD SISSINNVNN INNVNNINNV
NNINNVNNIN NVKNIVDINN YLVNNLQLNK DNDNIIIIKF NILKLFKLGS CYLYIINRNL
KEIQMLKNQI LSLEESIKSL NEFINNLKNE NEKNELIKIN NFEEILKLKN NLQDNESCIQ
NLNNYLKKNE ELNKINVKNI FKYKGYIIHL IQQSNVFCKI FKHFNENKII DQSIINKLLY
LKKSFDFYMY DSVIQEIREN KNIIINQDFL TDEYFKHIQT FTKTCNVLIQ RGYLSILKDT
NNDFFIQNKQ SNQQGNQNGN HINMCNIYPD DEINVTADQQ IFDGTENVQQ SLQNEEDYVN
NEEMYTDKMD LDNNMNGDDD DDDDDDDDDD NNNNNNNNNN NNNNNMGDED NHLVNAFNNH
NLLTNGNVKS DQINNETLER YEENIIQNIY TNDNVDNNQV IENINKILIK DKQDIINNDE
LKNEHNNLIR LINESIENAH NLENVYVQND ANNLINDNIK KEETLTYVDE KDNVSNESNS
KCDDDKKENE DIIQAKNENY PVSTHYDNND DINKDNINND NNNDNINDDN NNDNINNDNN
NDNINNDNIN NDNINNDNNN DNNNDNSNNG FVCELSSNIN DFNNILNVNK DNFQGINKSN
NFSTNLSEYN YDAYVKIVEA GSALENKKQQ DKKRKYFSDS EITKENGYLG ESNSIKIRKV
SVGGDNDNND DDNNDDNDDD DNDDDNNDDD NNNDDDNDDS YDDEEKEQEN YSNDVNTELN
NHVTFEDISV HNNIQENKKN YFSNVHENTF NLHVDENVHE DLQNYEDYVN NNNNNNDDDN
EEESNNSCYI ISSDDEGDKK NVSKQNDDDE DDDDNGDDDD NEDDDDNEDD DNGDDDDNED
DDNGDDDDNE DDNYDDEDND NYENEDDDNY ANEDDDNYEN DDDDNYENDD DDNYENDDDN
YENDDDDNYE NGDDDNDNDH NDDNNDEEKY SCHDDKNEHT NNDLLNIDHD NNKNNITDEL
YSTYNVSVSH NKDPSNKENE IQNLISIDSS NENDENDEND ENDENDENDE NDENDENDEN
DENDEKDEND ENDENDENFD NNNEGTLNEM NSEE
