LRR70_HUMAN
ID LRR70_HUMAN Reviewed; 622 AA.
AC Q7Z2Q7; Q6ZWI5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Leucine-rich repeat-containing protein 70;
DE AltName: Full=Synleurin;
DE Flags: Precursor;
GN Name=LRRC70; ORFNames=UNQ1891/PRO4337;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12767927; DOI=10.1016/s0006-291x(03)00876-3;
RA Wang W., Yang Y., Li L., Shi Y.;
RT "Synleurin, a novel leucine-rich repeat protein that increases the
RT intensity of pleiotropic cytokine responses.";
RL Biochem. Biophys. Res. Commun. 305:981-988(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Renders cells highly sensitive to the activation by cytokines
CC and lipopolysaccharide (LPS). {ECO:0000269|PubMed:12767927}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels in many tissues, including
CC smooth muscle, brain, uterus, pancreas, cartilage, adipose, spleen and
CC testis. {ECO:0000269|PubMed:12767927}.
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DR EMBL; AY280614; AAP36706.1; -; mRNA.
DR EMBL; AY358733; AAQ89095.1; -; mRNA.
DR EMBL; AK123022; BAC85517.1; -; mRNA.
DR EMBL; CH471137; EAW51382.1; -; Genomic_DNA.
DR CCDS; CCDS47218.1; -.
DR RefSeq; NP_852607.3; NM_181506.4.
DR AlphaFoldDB; Q7Z2Q7; -.
DR SMR; Q7Z2Q7; -.
DR BioGRID; 131676; 3.
DR IntAct; Q7Z2Q7; 1.
DR STRING; 9606.ENSP00000399441; -.
DR GlyGen; Q7Z2Q7; 5 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q7Z2Q7; -.
DR PhosphoSitePlus; Q7Z2Q7; -.
DR BioMuta; LRRC70; -.
DR DMDM; 74759111; -.
DR PaxDb; Q7Z2Q7; -.
DR PeptideAtlas; Q7Z2Q7; -.
DR PRIDE; Q7Z2Q7; -.
DR ProteomicsDB; 68964; -.
DR Antibodypedia; 23715; 62 antibodies from 14 providers.
DR DNASU; 100130733; -.
DR Ensembl; ENST00000334994.6; ENSP00000399441.1; ENSG00000186105.8.
DR GeneID; 100130733; -.
DR KEGG; hsa:100130733; -.
DR MANE-Select; ENST00000334994.6; ENSP00000399441.1; NM_181506.5; NP_852607.3.
DR UCSC; uc011cqs.1; human.
DR CTD; 100130733; -.
DR GeneCards; LRRC70; -.
DR HGNC; HGNC:35155; LRRC70.
DR HPA; ENSG00000186105; Low tissue specificity.
DR neXtProt; NX_Q7Z2Q7; -.
DR OpenTargets; ENSG00000186105; -.
DR PharmGKB; PA164722127; -.
DR VEuPathDB; HostDB:ENSG00000186105; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000163637; -.
DR HOGENOM; CLU_484489_0_0_1; -.
DR InParanoid; Q7Z2Q7; -.
DR OMA; HNPIEAI; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q7Z2Q7; -.
DR TreeFam; TF331598; -.
DR PathwayCommons; Q7Z2Q7; -.
DR SignaLink; Q7Z2Q7; -.
DR BioGRID-ORCS; 100130733; 11 hits in 1070 CRISPR screens.
DR GenomeRNAi; 100130733; -.
DR Pharos; Q7Z2Q7; Tdark.
DR PRO; PR:Q7Z2Q7; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q7Z2Q7; protein.
DR Bgee; ENSG00000186105; Expressed in subcutaneous adipose tissue and 95 other tissues.
DR ExpressionAtlas; Q7Z2Q7; baseline and differential.
DR Genevisible; Q7Z2Q7; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0060760; P:positive regulation of response to cytokine stimulus; IMP:UniProtKB.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR PROSITE; PS51450; LRR; 11.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..622
FT /note="Leucine-rich repeat-containing protein 70"
FT /id="PRO_0000317750"
FT TRANSMEM 527..547
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 32..60
FT /note="LRRNT"
FT REPEAT 61..82
FT /note="LRR 1"
FT REPEAT 85..106
FT /note="LRR 2"
FT REPEAT 109..130
FT /note="LRR 3"
FT REPEAT 133..154
FT /note="LRR 4"
FT REPEAT 157..178
FT /note="LRR 5"
FT REPEAT 181..202
FT /note="LRR 6"
FT REPEAT 205..226
FT /note="LRR 7"
FT REPEAT 229..250
FT /note="LRR 8"
FT REPEAT 253..274
FT /note="LRR 9"
FT REPEAT 277..298
FT /note="LRR 10"
FT REPEAT 301..322
FT /note="LRR 11"
FT REPEAT 326..347
FT /note="LRR 12"
FT DOMAIN 359..406
FT /note="LRRCT"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 266
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 331
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 400
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 614
FT /note="V -> A (in Ref. 3; BAC85517)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 622 AA; 70301 MW; 49D2EE78153F2C60 CRC64;
MCGLQFSLPC LRLFLVVTCY LLLLLHKEIL GCSSVCQLCT GRQINCRNLG LSSIPKNFPE
STVFLYLTGN NISYINESEL TGLHSLVALY LDNSNILYVY PKAFVQLRHL YFLFLNNNFI
KRLDPGIFKG LLNLRNLYLQ YNQVSFVPRG VFNDLVSVQY LNLQRNRLTV LGSGTFVGMV
ALRILDLSNN NILRISESGF QHLENLACLY LGSNNLTKVP SNAFEVLKSL RRLSLSHNPI
EAIQPFAFKG LANLEYLLLK NSRIRNVTRD GFSGINNLKH LILSHNDLEN LNSDTFSLLK
NLIYLKLDRN RIISIDNDTF ENMGASLKIL NLSFNNLTAL HPRVLKPLSS LIHLQANSNP
WECNCKLLGL RDWLASSAIT LNIYCQNPPS MRGRALRYIN ITNCVTSSIN VSRAWAVVKS
PHIHHKTTAL MMAWHKVTTN GSPLENTETE NITFWERIPT SPAGRFFQEN AFGNPLETTA
VLPVQIQLTT SVTLNLEKNS ALPNDAASMS GKTSLICTQE VEKLNEAFDI LLAFFILACV
LIIFLIYKVV QFKQKLKASE NSRENRLEYY SFYQSARYNV TASICNTSPN SLESPGLEQI
RLHKQIVPEN EAQVILFEHS AL
