LRRC1_MOUSE
ID LRRC1_MOUSE Reviewed; 524 AA.
AC Q80VQ1; Q3UI50; Q8BKR1; Q8BUS9;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Leucine-rich repeat-containing protein 1;
GN Name=Lrrc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=NMRI; TISSUE=Mammary gland, and Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with DLG1. May form a complex with DLG1 and ERBIN,
CC where interaction between LRRC1 and ERBIN is indirect (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Note=Localized at the
CC basolateral side of epithelial cells. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q80VQ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80VQ1-2; Sequence=VSP_010914;
CC Name=3;
CC IsoId=Q80VQ1-3; Sequence=VSP_010915, VSP_010916;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH46591.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK051043; BAC34508.1; -; mRNA.
DR EMBL; AK082721; BAC38586.1; -; mRNA.
DR EMBL; AK147075; BAE27656.1; -; mRNA.
DR EMBL; BC046591; AAH46591.1; ALT_INIT; mRNA.
DR EMBL; BC087542; AAH87542.1; -; mRNA.
DR CCDS; CCDS72282.1; -. [Q80VQ1-1]
DR RefSeq; NP_001139520.1; NM_001146048.1. [Q80VQ1-1]
DR RefSeq; NP_766116.3; NM_172528.3.
DR AlphaFoldDB; Q80VQ1; -.
DR SMR; Q80VQ1; -.
DR BioGRID; 229517; 1.
DR IntAct; Q80VQ1; 1.
DR STRING; 10090.ENSMUSP00000109048; -.
DR iPTMnet; Q80VQ1; -.
DR PhosphoSitePlus; Q80VQ1; -.
DR SwissPalm; Q80VQ1; -.
DR EPD; Q80VQ1; -.
DR jPOST; Q80VQ1; -.
DR MaxQB; Q80VQ1; -.
DR PaxDb; Q80VQ1; -.
DR PeptideAtlas; Q80VQ1; -.
DR PRIDE; Q80VQ1; -.
DR ProteomicsDB; 292365; -. [Q80VQ1-1]
DR ProteomicsDB; 292366; -. [Q80VQ1-2]
DR ProteomicsDB; 292367; -. [Q80VQ1-3]
DR Antibodypedia; 17278; 95 antibodies from 26 providers.
DR DNASU; 214345; -.
DR Ensembl; ENSMUST00000183734; ENSMUSP00000138912; ENSMUSG00000032352. [Q80VQ1-3]
DR Ensembl; ENSMUST00000183873; ENSMUSP00000139226; ENSMUSG00000032352. [Q80VQ1-1]
DR GeneID; 214345; -.
DR KEGG; mmu:214345; -.
DR UCSC; uc009qtk.2; mouse. [Q80VQ1-1]
DR CTD; 55227; -.
DR MGI; MGI:2442313; Lrrc1.
DR VEuPathDB; HostDB:ENSMUSG00000032352; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000154025; -.
DR HOGENOM; CLU_000288_18_23_1; -.
DR InParanoid; Q80VQ1; -.
DR OMA; VIDKRHC; -.
DR PhylomeDB; Q80VQ1; -.
DR Reactome; R-MMU-9696270; RND2 GTPase cycle.
DR BioGRID-ORCS; 214345; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Lrrc1; mouse.
DR PRO; PR:Q80VQ1; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q80VQ1; protein.
DR Bgee; ENSMUSG00000032352; Expressed in spermatid and 225 other tissues.
DR ExpressionAtlas; Q80VQ1; baseline and differential.
DR Genevisible; Q80VQ1; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 12.
DR PROSITE; PS51450; LRR; 15.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Leucine-rich repeat;
KW Membrane; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..524
FT /note="Leucine-rich repeat-containing protein 1"
FT /id="PRO_0000084490"
FT REPEAT 11..34
FT /note="LRR 1"
FT REPEAT 35..58
FT /note="LRR 2"
FT REPEAT 60..81
FT /note="LRR 3"
FT REPEAT 83..105
FT /note="LRR 4"
FT REPEAT 107..126
FT /note="LRR 5"
FT REPEAT 127..149
FT /note="LRR 6"
FT REPEAT 150..172
FT /note="LRR 7"
FT REPEAT 173..196
FT /note="LRR 8"
FT REPEAT 198..218
FT /note="LRR 9"
FT REPEAT 219..242
FT /note="LRR 10"
FT REPEAT 244..264
FT /note="LRR 11"
FT REPEAT 265..288
FT /note="LRR 12"
FT REPEAT 290..310
FT /note="LRR 13"
FT REPEAT 311..334
FT /note="LRR 14"
FT REPEAT 336..356
FT /note="LRR 15"
FT REPEAT 357..380
FT /note="LRR 16"
FT REPEAT 382..405
FT /note="LRR 17"
FT REGION 464..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 456..512
FT /evidence="ECO:0000255"
FT COMPBIAS 470..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 480
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9BTT6"
FT VAR_SEQ 1..81
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010914"
FT VAR_SEQ 331..349
FT /note="IGGCCSLTMFCIRDNRLTR -> EHISGKVCRLFYHKAATAI (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010915"
FT VAR_SEQ 350..524
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010916"
FT CONFLICT 115
FT /note="N -> D (in Ref. 1; BAC38586)"
FT /evidence="ECO:0000305"
FT CONFLICT 369
FT /note="R -> K (in Ref. 1; BAC34508)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 524 AA; 59412 MW; 546AA6726A1109D8 CRC64;
MFHCIPLWRC NRHVEAIDKR HCSLVYVPEE IYRYARSLEE LLLDANQLRE LPEQFFQLVK
LRKLGLSDNE IQRLPPEIAN FMQLVELDVS RNDIPEIPES IAFCKALQVA DFSGNPLTRL
PESFPELQNL TCLSVNDISL QSLPENIGNL YNLASLELRE NLLTYLPDSL TQLRRLEELD
LGNNEIYNLP ESIGALLHLK DLWLDGNQLS ELPQEIGNLK NLLCLDVSEN RLERLPEEIS
GLTSLTYLVI SQNLLETIPE GIGKLKKLSI LKLDQNRLTQ LPEAIGDCEN LTELVLTENR
LLTLPKSIGK LKKLSNLNAD RNKLVSLPKE IGGCCSLTMF CIRDNRLTRL PAEVSQAVEL
HVLDVAGNRL HHLPLSLTTL KLKALWLSDN QSQPLLTFQT DIDRATGEKI LTCVLLPQMP
SEPICQESLP RCGALESLVT DMSEEAWNDR SVHRVSAIRF LEDEKDEDEN ETRTLQRRAT
PHPGELKNMK KTVENLRNDM NAAKGLDSNK NEVNHAAERV TTSV
