LRRC2_HUMAN
ID LRRC2_HUMAN Reviewed; 371 AA.
AC Q9BYS8; B2RDQ7; Q96LT5;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Leucine-rich repeat-containing protein 2;
GN Name=LRRC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLU-145.
RX PubMed=11896456; DOI=10.1038/sj.ejhg.5200758;
RA Kiss H., Yang Y., Kiss C., Andersson K., Klein G., Imreh S., Dumanski J.P.;
RT "The transcriptional map of the common eliminated region 1 (C3CER1) in
RT 3p21.3.";
RL Eur. J. Hum. Genet. 10:52-61(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-32.
RC TISSUE=Cerebellum, and Synovium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, Kidney, and Stomach;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AJ308569; CAC33442.1; -; mRNA.
DR EMBL; AK057808; BAB71585.1; -; mRNA.
DR EMBL; AK315636; BAG38004.1; -; mRNA.
DR EMBL; BC029118; AAH29118.1; -; mRNA.
DR CCDS; CCDS2741.1; -.
DR RefSeq; NP_078788.2; NM_024512.4.
DR RefSeq; XP_011532412.1; XM_011534110.2.
DR AlphaFoldDB; Q9BYS8; -.
DR SMR; Q9BYS8; -.
DR BioGRID; 122668; 2.
DR IntAct; Q9BYS8; 3.
DR STRING; 9606.ENSP00000379241; -.
DR iPTMnet; Q9BYS8; -.
DR PhosphoSitePlus; Q9BYS8; -.
DR BioMuta; LRRC2; -.
DR DMDM; 23821855; -.
DR MassIVE; Q9BYS8; -.
DR PaxDb; Q9BYS8; -.
DR PeptideAtlas; Q9BYS8; -.
DR PRIDE; Q9BYS8; -.
DR ProteomicsDB; 79700; -.
DR Antibodypedia; 29724; 148 antibodies from 20 providers.
DR DNASU; 79442; -.
DR Ensembl; ENST00000296144.3; ENSP00000296144.3; ENSG00000163827.14.
DR Ensembl; ENST00000395905.8; ENSP00000379241.3; ENSG00000163827.14.
DR Ensembl; ENST00000682605.1; ENSP00000507018.1; ENSG00000163827.14.
DR GeneID; 79442; -.
DR KEGG; hsa:79442; -.
DR MANE-Select; ENST00000395905.8; ENSP00000379241.3; NM_024512.5; NP_078788.2.
DR UCSC; uc003cpu.5; human.
DR CTD; 79442; -.
DR DisGeNET; 79442; -.
DR GeneCards; LRRC2; -.
DR HGNC; HGNC:14676; LRRC2.
DR HPA; ENSG00000163827; Group enriched (heart muscle, skeletal muscle, tongue).
DR MIM; 607180; gene.
DR neXtProt; NX_Q9BYS8; -.
DR OpenTargets; ENSG00000163827; -.
DR PharmGKB; PA30461; -.
DR VEuPathDB; HostDB:ENSG00000163827; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000154960; -.
DR HOGENOM; CLU_000288_18_8_1; -.
DR InParanoid; Q9BYS8; -.
DR OMA; EHWKELP; -.
DR OrthoDB; 1025459at2759; -.
DR PhylomeDB; Q9BYS8; -.
DR TreeFam; TF333627; -.
DR PathwayCommons; Q9BYS8; -.
DR SignaLink; Q9BYS8; -.
DR BioGRID-ORCS; 79442; 44 hits in 1070 CRISPR screens.
DR ChiTaRS; LRRC2; human.
DR GenomeRNAi; 79442; -.
DR Pharos; Q9BYS8; Tdark.
DR PRO; PR:Q9BYS8; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9BYS8; protein.
DR Bgee; ENSG00000163827; Expressed in skeletal muscle tissue of rectus abdominis and 145 other tissues.
DR Genevisible; Q9BYS8; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..371
FT /note="Leucine-rich repeat-containing protein 2"
FT /id="PRO_0000084491"
FT REPEAT 122..143
FT /note="LRR 1"
FT REPEAT 145..166
FT /note="LRR 2"
FT REPEAT 168..189
FT /note="LRR 3"
FT REPEAT 191..214
FT /note="LRR 4"
FT REPEAT 215..235
FT /note="LRR 5"
FT REPEAT 238..260
FT /note="LRR 6"
FT REPEAT 261..283
FT /note="LRR 7"
FT REPEAT 284..305
FT /note="LRR 8"
FT REPEAT 308..329
FT /note="LRR 9"
FT VARIANT 32
FT /note="V -> A (in dbSNP:rs28687398)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_051140"
FT VARIANT 83
FT /note="T -> A (in dbSNP:rs17286758)"
FT /id="VAR_051141"
FT VARIANT 145
FT /note="A -> E (in dbSNP:rs17078944)"
FT /evidence="ECO:0000269|PubMed:11896456"
FT /id="VAR_051142"
FT CONFLICT 30
FT /note="K -> R (in Ref. 2; BAB71585)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 371 AA; 42943 MW; FF67A824F26680C3 CRC64;
MGHKVVVFDI SVIRALWETR VKKHKAWQKK EVERLEKSAL EKIKEEWNFV AECRRKGIPQ
AVYCKNGFID TSVRLLDKIE RNTLTRQSSL PKDRGKRSSA FVFELSGEHW TELPDSLKEQ
THLREWYISN TLIQIIPTYI QLFQAMRILD LPKNQISHLP AEIGCLKNLK ELNVGFNYLK
SIPPELGDCE NLERLDCSGN LELMELPFEL SNLKQVTFVD ISANKFSSVP ICVLRMSNLQ
WLDISSNNLT DLPQDIDRLE ELQSFLLYKN KLTYLPYSML NLKKLTLLVV SGDHLVELPT
ALCDSSTPLK FVSLMDNPID NAQCEDGNEI MESERDRQHF DKEVMKAYIE DLKERESVPS
YTTKVSFSLQ L
