LRRC2_MOUSE
ID LRRC2_MOUSE Reviewed; 371 AA.
AC Q8VDB8; Q9CX04;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Leucine-rich repeat-containing protein 2;
GN Name=Lrrc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=12461651; DOI=10.1007/s00335-002-3037-y;
RA Kiss H., Darai E., Kiss C., Kost-Alimova M., Klein G., Dumanski J.P.,
RA Imreh S.;
RT "Comparative human/murine sequence analysis of the common eliminated region
RT 1 from human 3p21.3.";
RL Mamm. Genome 13:646-655(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic stem cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
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DR EMBL; AJ428068; CAD20990.1; -; mRNA.
DR EMBL; AK010252; BAB26797.1; -; mRNA.
DR CCDS; CCDS23580.1; -.
DR RefSeq; NP_083114.2; NM_028838.2.
DR RefSeq; XP_006512428.1; XM_006512365.3.
DR AlphaFoldDB; Q8VDB8; -.
DR SMR; Q8VDB8; -.
DR IntAct; Q8VDB8; 1.
DR STRING; 10090.ENSMUSP00000035076; -.
DR PhosphoSitePlus; Q8VDB8; -.
DR PaxDb; Q8VDB8; -.
DR PRIDE; Q8VDB8; -.
DR ProteomicsDB; 290169; -.
DR DNASU; 74249; -.
DR GeneID; 74249; -.
DR KEGG; mmu:74249; -.
DR UCSC; uc009rvh.1; mouse.
DR CTD; 79442; -.
DR MGI; MGI:1921499; Lrrc2.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; Q8VDB8; -.
DR OrthoDB; 1025459at2759; -.
DR PhylomeDB; Q8VDB8; -.
DR TreeFam; TF333627; -.
DR BioGRID-ORCS; 74249; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Lrrc2; mouse.
DR PRO; PR:Q8VDB8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8VDB8; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEP:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00369; LRR_TYP; 3.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..371
FT /note="Leucine-rich repeat-containing protein 2"
FT /id="PRO_0000084492"
FT REPEAT 122..143
FT /note="LRR 1"
FT REPEAT 145..166
FT /note="LRR 2"
FT REPEAT 168..189
FT /note="LRR 3"
FT REPEAT 191..214
FT /note="LRR 4"
FT REPEAT 215..235
FT /note="LRR 5"
FT REPEAT 238..260
FT /note="LRR 6"
FT REPEAT 261..282
FT /note="LRR 7"
FT REPEAT 284..305
FT /note="LRR 8"
FT REPEAT 308..329
FT /note="LRR 9"
FT CONFLICT 52
FT /note="Q -> E (in Ref. 2; BAB26797)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 371 AA; 42956 MW; 55E96FF2D60E6A23 CRC64;
MGHKVVVFDI SVVRALWETR VKKHKAWQKK EAERLEKSAL EKIKEEWDFV AQCRRKGVPQ
AEYCKNGFVD TSTRLLEKIE RNSVSRQSAR VKDRDKRRSP FVFELSGTQW KELPDSLKEQ
THLKEWYIHS TLIQIIPTYI ELFQAMKILD LPKNQITCLP AEIGRLKNLK ELNVSFNHLK
SIPPELGDCE HLERLDCSGN LDLMDLPFEL SNLKQVTFVD ISANKFSSVP ICVLRMCRLQ
WLDISSNNLS DLPQDIDRLE ELQGFLLYKN KLTYLPQAML NLKKLTLLVV SGDHLVEVPT
ALCDASTPLK FVSLVDNPID KTGCQDTEDT VESERDRQHF DKEFMKAYIE DLKEREAVPS
YTTKVSFSLQ L
