ID   LRRC3_BOVIN             Reviewed;         257 AA.
AC   A6H793;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Leucine-rich repeat-containing protein 3;
DE   Flags: Precursor;
GN   Name=LRRC3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LRRC3 family. {ECO:0000305}.
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DR   EMBL; BC146159; AAI46160.1; -; mRNA.
DR   RefSeq; NP_001092354.1; NM_001098884.1.
DR   AlphaFoldDB; A6H793; -.
DR   SMR; A6H793; -.
DR   STRING; 9913.ENSBTAP00000023769; -.
DR   PaxDb; A6H793; -.
DR   Ensembl; ENSBTAT00000023769; ENSBTAP00000023769; ENSBTAG00000017882.
DR   GeneID; 506054; -.
DR   KEGG; bta:506054; -.
DR   CTD; 81543; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017882; -.
DR   VGNC; VGNC:31008; LRRC3.
DR   eggNOG; KOG4237; Eukaryota.
DR   GeneTree; ENSGT00940000154360; -.
DR   HOGENOM; CLU_064640_0_0_1; -.
DR   InParanoid; A6H793; -.
DR   OMA; QCPDHAG; -.
DR   OrthoDB; 1050061at2759; -.
DR   TreeFam; TF327070; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000017882; Expressed in liver and 92 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01462; LRRNT; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..257
FT                   /note="Leucine-rich repeat-containing protein 3"
FT                   /id="PRO_0000345963"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          33..64
FT                   /note="LRRNT"
FT   REPEAT          65..86
FT                   /note="LRR 1"
FT   REPEAT          89..110
FT                   /note="LRR 2"
FT   REPEAT          114..135
FT                   /note="LRR 3"
FT   DOMAIN          145..198
FT                   /note="LRRCT"
SQ   SEQUENCE   257 AA;  28000 MW;  E7FCEFE254519C72 CRC64;
     MGPTGRQSPS SLPVPAGGPC LLLLFCLRLG ASCPQNCQCP DHAGAVAVHC SARGLQEVPR
     DIPADTVLLK LDANKIARIP NGAFQHLHQL RELDLSQNAI ETIGPAAFSG LAGGLRLLDL
     SHNRLRRIPK DALGKLSAKI RLAHNPLHCE CALQEALWEL KLDPDSVDEI ACHTSVQEEY
     VGKPLIQALD SGVSFCSVHH KTTDVAMLVT MFGWFAMVIT YVVYYVRQNQ EDARRHLEYL
     KSLPSTPMSK DPTSSAP