LRRC3_DANRE
ID LRRC3_DANRE Reviewed; 266 AA.
AC A8WHP9; A8BB12;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Leucine-rich repeat-containing protein 3;
DE Flags: Precursor;
GN Name=lrrc3; ORFNames=sc:d0333, si:dkey-253a1.3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-209.
RX PubMed=18296487; DOI=10.1101/gr.7187808;
RA Bushell K.M., Soellner C., Schuster-Boeckler B., Bateman A., Wright G.J.;
RT "Large-scale screening for novel low-affinity extracellular protein
RT interactions.";
RL Genome Res. 18:622-630(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the LRRC3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAP07984.1; Type=Miscellaneous discrepancy; Note=C-terminus of translation can be extended by 1 residue.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX247868; CAP19488.1; -; Genomic_DNA.
DR EMBL; CU468760; CAP07984.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001107114.1; NM_001113642.1.
DR RefSeq; XP_009303150.1; XM_009304875.2.
DR AlphaFoldDB; A8WHP9; -.
DR SMR; A8WHP9; -.
DR STRING; 7955.ENSDARP00000120615; -.
DR PaxDb; A8WHP9; -.
DR Ensembl; ENSDART00000142888; ENSDARP00000120615; ENSDARG00000078415.
DR GeneID; 100001372; -.
DR KEGG; dre:100001372; -.
DR CTD; 81543; -.
DR ZFIN; ZDB-GENE-080327-13; lrrc3.
DR eggNOG; KOG4237; Eukaryota.
DR GeneTree; ENSGT00940000154360; -.
DR HOGENOM; CLU_064640_0_0_1; -.
DR InParanoid; A8WHP9; -.
DR OMA; QCPDHAG; -.
DR OrthoDB; 1050061at2759; -.
DR PhylomeDB; A8WHP9; -.
DR TreeFam; TF327070; -.
DR PRO; PR:A8WHP9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000078415; Expressed in early embryo and 15 other tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00013; LRRNT; 1.
DR PROSITE; PS51450; LRR; 3.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..38
FT /evidence="ECO:0000255"
FT CHAIN 39..266
FT /note="Leucine-rich repeat-containing protein 3"
FT /id="PRO_0000345964"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 39..70
FT /note="LRRNT"
FT REPEAT 71..92
FT /note="LRR 1"
FT REPEAT 95..116
FT /note="LRR 2"
FT REPEAT 120..141
FT /note="LRR 3"
FT DOMAIN 151..204
FT /note="LRRCT"
SQ SEQUENCE 266 AA; 30055 MW; 5DE44ECD0E09B2A7 CRC64;
MTFPAGAYVL RKVFIPHGCP LIFRLLLAVI CLSVPSFACP KSCHCSERNS LTVVQCSSRN
LEEIPPDLPH DTVSLQLSSN HITKIPNQAF KNLPWLQELD LSRNAIETVD AGAFKGVSES
LRTLDLSHNH MQGVPKEAFA RLHAKISLSN NPWHCECTLQ EVLRELRLDP ETVNEVSCHT
SDQEKYAGKP VIQVLDSGIN FCNFHHKTTD VAMFVTMFGW FTMVIAYVIY YVRHNQEDAR
RHLEYLKSLP SSSQISKDFD TISTVL
