LRRC3_HUMAN
ID LRRC3_HUMAN Reviewed; 257 AA.
AC Q9BY71; Q0VDJ2;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Leucine-rich repeat-containing protein 3;
DE Flags: Precursor;
GN Name=LRRC3; Synonyms=C21orf102, LRRC3A; ORFNames=UNQ9233/PRO31982;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hahn Y., Park H.-S., Kim Y.S.;
RT "A novel leucine-rich repeat-containing gene LRRC3 on the human chromosome
RT 21.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12036297; DOI=10.1006/geno.2002.6781;
RA Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B.,
RA Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S.,
RA Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E.;
RT "Nineteen additional unpredicted transcripts from human chromosome 21.";
RL Genomics 79:824-832(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BY71; P16333: NCK1; NbExp=2; IntAct=EBI-1761329, EBI-389883;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed; detected in testis, lung, small
CC intestine, breast, brain, heart, bone marrow, placenta, colon, fetal
CC brain, liver, fetal liver, thymus, salivary gland, spinal cord, spleen,
CC trachea and adrenal gland.
CC -!- SIMILARITY: Belongs to the LRRC3 family. {ECO:0000305}.
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DR EMBL; AB058646; BAB40229.1; -; mRNA.
DR EMBL; AY061857; AAL35741.1; -; mRNA.
DR EMBL; AY358120; AAQ88487.1; -; mRNA.
DR EMBL; BC119648; AAI19649.1; -; mRNA.
DR EMBL; BC119649; AAI19650.1; -; mRNA.
DR CCDS; CCDS13711.1; -.
DR RefSeq; NP_112153.1; NM_030891.4.
DR AlphaFoldDB; Q9BY71; -.
DR SMR; Q9BY71; -.
DR BioGRID; 123511; 17.
DR IntAct; Q9BY71; 10.
DR STRING; 9606.ENSP00000291592; -.
DR iPTMnet; Q9BY71; -.
DR PhosphoSitePlus; Q9BY71; -.
DR BioMuta; LRRC3; -.
DR DMDM; 18202742; -.
DR EPD; Q9BY71; -.
DR MassIVE; Q9BY71; -.
DR PaxDb; Q9BY71; -.
DR PeptideAtlas; Q9BY71; -.
DR PRIDE; Q9BY71; -.
DR ProteomicsDB; 79596; -.
DR Antibodypedia; 2538; 40 antibodies from 15 providers.
DR DNASU; 81543; -.
DR Ensembl; ENST00000291592.6; ENSP00000291592.4; ENSG00000160233.8.
DR GeneID; 81543; -.
DR KEGG; hsa:81543; -.
DR MANE-Select; ENST00000291592.6; ENSP00000291592.4; NM_030891.6; NP_112153.1.
DR UCSC; uc002zfa.4; human.
DR CTD; 81543; -.
DR DisGeNET; 81543; -.
DR GeneCards; LRRC3; -.
DR HGNC; HGNC:14965; LRRC3.
DR HPA; ENSG00000160233; Tissue enhanced (liver).
DR MIM; 617620; gene.
DR neXtProt; NX_Q9BY71; -.
DR OpenTargets; ENSG00000160233; -.
DR PharmGKB; PA30462; -.
DR VEuPathDB; HostDB:ENSG00000160233; -.
DR eggNOG; KOG4237; Eukaryota.
DR GeneTree; ENSGT00940000154360; -.
DR HOGENOM; CLU_064640_0_0_1; -.
DR InParanoid; Q9BY71; -.
DR OMA; QCPDHAG; -.
DR OrthoDB; 1050061at2759; -.
DR PhylomeDB; Q9BY71; -.
DR TreeFam; TF327070; -.
DR PathwayCommons; Q9BY71; -.
DR SignaLink; Q9BY71; -.
DR BioGRID-ORCS; 81543; 13 hits in 1061 CRISPR screens.
DR GenomeRNAi; 81543; -.
DR Pharos; Q9BY71; Tdark.
DR PRO; PR:Q9BY71; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q9BY71; protein.
DR Bgee; ENSG00000160233; Expressed in right lobe of liver and 120 other tissues.
DR Genevisible; Q9BY71; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00013; LRRNT; 1.
DR PROSITE; PS51450; LRR; 3.
PE 1: Evidence at protein level;
KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..257
FT /note="Leucine-rich repeat-containing protein 3"
FT /id="PRO_0000021618"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 33..64
FT /note="LRRNT"
FT REPEAT 65..86
FT /note="LRR 1"
FT REPEAT 89..110
FT /note="LRR 2"
FT REPEAT 114..135
FT /note="LRR 3"
FT REPEAT 136..157
FT /note="LRR 4"
SQ SEQUENCE 257 AA; 28108 MW; C668FAACF5E68148 CRC64;
MGTVRPPRPS LLLVSTRESC LFLLFCLHLG AACPQPCRCP DHAGAVAVFC SLRGLQEVPE
DIPANTVLLK LDANKISHLP DGAFQHLHRL RELDLSHNAI EAIGSATFAG LAGGLRLLDL
SYNRIQRIPK DALGKLSAKI RLSHNPLHCE CALQEALWEL KLDPDSVDEI ACHTSVQEEF
VGKPLVQALD AGASLCSVPH RTTDVAMLVT MFGWFAMVIA YVVYYVRHNQ EDARRHLEYL
KSLPSAPASK DPIGPGP
