ID   LRRC3_MOUSE             Reviewed;         257 AA.
AC   P59034;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Leucine-rich repeat-containing protein 3;
DE   Flags: Precursor;
GN   Name=Lrrc3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12036297; DOI=10.1006/geno.2002.6781;
RA   Reymond A., Camargo A.A., Deutsch S., Stevenson B.J., Parmigiani R.B.,
RA   Ucla C., Bettoni F., Rossier C., Lyle R., Guipponi M., de Souza S.,
RA   Iseli C., Jongeneel C.V., Bucher P., Simpson A.J.G., Antonarakis S.E.;
RT   "Nineteen additional unpredicted transcripts from human chromosome 21.";
RL   Genomics 79:824-832(2002).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LRRC3 family. {ECO:0000305}.
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DR   EMBL; AY061858; AAL35742.1; -; mRNA.
DR   CCDS; CCDS23960.1; -.
DR   RefSeq; NP_660134.1; NM_145152.4.
DR   AlphaFoldDB; P59034; -.
DR   SMR; P59034; -.
DR   STRING; 10090.ENSMUSP00000059570; -.
DR   iPTMnet; P59034; -.
DR   PhosphoSitePlus; P59034; -.
DR   PaxDb; P59034; -.
DR   PRIDE; P59034; -.
DR   ProteomicsDB; 292368; -.
DR   Antibodypedia; 2538; 40 antibodies from 15 providers.
DR   DNASU; 237387; -.
DR   Ensembl; ENSMUST00000057608; ENSMUSP00000059570; ENSMUSG00000051652.
DR   GeneID; 237387; -.
DR   KEGG; mmu:237387; -.
DR   UCSC; uc007fwi.3; mouse.
DR   CTD; 81543; -.
DR   MGI; MGI:2447899; Lrrc3.
DR   VEuPathDB; HostDB:ENSMUSG00000051652; -.
DR   eggNOG; KOG4237; Eukaryota.
DR   GeneTree; ENSGT00940000154360; -.
DR   HOGENOM; CLU_064640_0_0_1; -.
DR   InParanoid; P59034; -.
DR   OMA; QCPDHAG; -.
DR   OrthoDB; 1050061at2759; -.
DR   PhylomeDB; P59034; -.
DR   TreeFam; TF327070; -.
DR   BioGRID-ORCS; 237387; 1 hit in 70 CRISPR screens.
DR   PRO; PR:P59034; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; P59034; protein.
DR   Bgee; ENSMUSG00000051652; Expressed in lumbar dorsal root ganglion and 151 other tissues.
DR   ExpressionAtlas; P59034; baseline and differential.
DR   Genevisible; P59034; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01462; LRRNT; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   1: Evidence at protein level;
KW   Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..257
FT                   /note="Leucine-rich repeat-containing protein 3"
FT                   /id="PRO_0000021619"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          33..64
FT                   /note="LRRNT"
FT   REPEAT          65..86
FT                   /note="LRR 1"
FT   REPEAT          89..110
FT                   /note="LRR 2"
FT   REPEAT          114..135
FT                   /note="LRR 3"
FT   DOMAIN          145..198
FT                   /note="LRRCT"
SQ   SEQUENCE   257 AA;  28119 MW;  79E9C0310406A647 CRC64;
     MGPRGRQSPS ATLAPSQGSC FFILFCLRLG ASCPQACQCP DHAGAVAVHC SSRGLQEIPR
     DIPADTVLLK LDANRISRVP NGAFQHLPQL RELDLSHNAI EAIGPAAFSG LAGGLRLLDL
     SHNRIRRIPK DALGKLSAKI RLSHNPLHCE CALQEALWEL KLDPDSVDEI ACHTSAQEQF
     VGKPLIQVLD SGASFCSTHR KTTDVAMLVT MFGWFTMVIA YVVYYVRHNQ EDARRHLEYL
     KSLPSAPVSK EPLSPVP