ID   LRRC3_RAT               Reviewed;         257 AA.
AC   P59035;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Leucine-rich repeat-containing protein 3;
DE   Flags: Precursor;
GN   Name=Lrrc3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hahn Y., Kim S., Kim Y.;
RT   "Rat leucine rich repeat protein LRRC3.";
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LRRC3 family. {ECO:0000305}.
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DR   EMBL; AB086432; BAC00923.1; -; mRNA.
DR   RefSeq; NP_663712.1; NM_145679.1.
DR   RefSeq; XP_006256302.1; XM_006256240.2.
DR   RefSeq; XP_017457030.1; XM_017601541.1.
DR   AlphaFoldDB; P59035; -.
DR   SMR; P59035; -.
DR   STRING; 10116.ENSRNOP00000001632; -.
DR   PaxDb; P59035; -.
DR   Ensembl; ENSRNOT00000001632; ENSRNOP00000001632; ENSRNOG00000001217.
DR   GeneID; 246773; -.
DR   KEGG; rno:246773; -.
DR   UCSC; RGD:628861; rat.
DR   CTD; 81543; -.
DR   RGD; 628861; Lrrc3.
DR   eggNOG; KOG4237; Eukaryota.
DR   GeneTree; ENSGT00940000154360; -.
DR   HOGENOM; CLU_064640_0_0_1; -.
DR   InParanoid; P59035; -.
DR   OMA; QCPDHAG; -.
DR   OrthoDB; 1050061at2759; -.
DR   PhylomeDB; P59035; -.
DR   TreeFam; TF327070; -.
DR   PRO; PR:P59035; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000001217; Expressed in heart and 15 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01462; LRRNT; 1.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 3.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..257
FT                   /note="Leucine-rich repeat-containing protein 3"
FT                   /id="PRO_0000021620"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          33..64
FT                   /note="LRRNT"
FT   REPEAT          65..86
FT                   /note="LRR 1"
FT   REPEAT          89..110
FT                   /note="LRR 2"
FT   REPEAT          114..135
FT                   /note="LRR 3"
FT   DOMAIN          145..198
FT                   /note="LRRCT"
SQ   SEQUENCE   257 AA;  28146 MW;  0F3A65C33DC6D640 CRC64;
     MGPRGRQSPS SPLAPSQGSC FFILFCLRLG ASCPQSCQCP DHAGAVAVHC SSRGLQEIPR
     DIPANTVLLK LDANRISRVP NGAFQHLPQL RELDLSHNAI EAIGPAAFSG LAGGLRLLDL
     SHNRIRRIPK DALGKLSAKI RLSHNPLHCE CALQEALWEL KLDPDSVDEI ACHTSAQEQF
     VGKPLIQVLD SGASFCSTHR KTTDVAMLVT MFGWFTMVIA YVVYYVRHNQ EDARRHLEYL
     KSLPSAPVSK EPLSPVP