LRRC7_BOVIN
ID LRRC7_BOVIN Reviewed; 1536 AA.
AC F1MCA7;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 3.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Leucine-rich repeat-containing protein 7;
DE AltName: Full=Densin-180;
DE Short=Densin;
GN Name=LRRC7;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
CC -!- FUNCTION: Required for normal synaptic spine architecture and function.
CC Necessary for DISC1 and GRM5 localization to postsynaptic density
CC complexes and for both N-methyl D-aspartate receptor-dependent and
CC metabotropic glutamate receptor-dependent long term depression (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CNKSR2 and DLG4 (By similarity). Interacts with
CC CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2.
CC Interacts with CAMK2A (By similarity). {ECO:0000250|UniProtKB:P70587,
CC ECO:0000250|UniProtKB:Q96NW7}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Postsynaptic density
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family.
CC {ECO:0000305}.
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DR EMBL; DAAA02008400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02008401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02008402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02008403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02008404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F1MCA7; -.
DR SMR; F1MCA7; -.
DR STRING; 9913.ENSBTAP00000012294; -.
DR PaxDb; F1MCA7; -.
DR PRIDE; F1MCA7; -.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; F1MCA7; -.
DR OrthoDB; 40683at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IBA:GO_Central.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS51450; LRR; 15.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Leucine-rich repeat; Methylation; Phosphoprotein;
KW Reference proteome; Repeat; Synapse.
FT CHAIN 1..1536
FT /note="Leucine-rich repeat-containing protein 7"
FT /id="PRO_0000416593"
FT REPEAT 21..44
FT /note="LRR 1"
FT REPEAT 45..68
FT /note="LRR 2"
FT REPEAT 70..91
FT /note="LRR 3"
FT REPEAT 92..114
FT /note="LRR 4"
FT REPEAT 116..137
FT /note="LRR 5"
FT REPEAT 138..159
FT /note="LRR 6"
FT REPEAT 160..183
FT /note="LRR 7"
FT REPEAT 185..206
FT /note="LRR 8"
FT REPEAT 207..228
FT /note="LRR 9"
FT REPEAT 230..251
FT /note="LRR 10"
FT REPEAT 252..274
FT /note="LRR 11"
FT REPEAT 275..297
FT /note="LRR 12"
FT REPEAT 299..320
FT /note="LRR 13"
FT REPEAT 321..343
FT /note="LRR 14"
FT REPEAT 345..366
FT /note="LRR 15"
FT REPEAT 367..389
FT /note="LRR 16"
FT REPEAT 392..415
FT /note="LRR 17"
FT DOMAIN 1444..1534
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 662..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1131..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1235..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1331..1351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 438
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 440
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70587"
FT MOD_RES 442
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 830
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 849
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 864
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 868
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 946
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 948
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 1117
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 1148
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 1232
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 1334
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70587"
FT MOD_RES 1438
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
SQ SEQUENCE 1536 AA; 172407 MW; CF3836939CB76C5A CRC64;
MTTKRKIIGR LVPCRCFRGE EEIISVLDYS HCSLQQVPKE VFNFERTLEE LYLDANQIEE
LPKQLFNCQA LKKLSIPDND LSNLPTTIAS LVNLKELDIS KNGVQEFPEN IKCCKCLTII
EASVNPISKL PDGFTQLLNL TQLYLNDAFL EFLPANFGRL AKLRILELRE NHLKTLPKSM
HKLAQLERLD LGNNEFSELP EVLDQIQNLR ELWMDNNALQ VLPGVWKLKM LVYLDMSKNR
IETVDMDISG CEALEDLLLS SNMLQQLPDS IGLLKKLTTL KVDDNQLTIL PNTIGNLSLL
EEFDCSCNEL ESLPSTIGYL HSLRTLAVDE NFLPELPREI GSCKNVTVMS LRSNKLEFLP
EEIGQMQKLR VLNLSDNRLK NLPFSFTKLK ELAALWLSDN QSKALIPLQT EAHPETKQRV
LTNYMFPQQP RGDEDFQSDS DSFNPTLWEE QRQQRMTVAF EFEEKKEDDE NAGKVKDHSC
QAPWERGQRG ITLQPARLSG DCCTPWARCD QQIQEMPVPQ NDPQLAWGCI SGLQQERSMC
TPLPVAAQST TLPSLSGRQV EINLKRYPTP YPEDLKNMVK SVQNLVGKPS HGVRVENSNP
TANTEQTVKE KYEHKWPVAP KEITVEDSFV HPANEMRIGE LHPSLAETPL YPPKLVLLGK
DKKESTDESE VDKTHCLNNS VSSGTYSDYS PSQASSGSSN TRVKVGSLQT TAKDAVHNSL
WGNRIAQSFP QPLDAKPLLS QREAVPTGNL PQRPDRLPIS DAFTDNWTDG SHYDNTGFVA
EETTGENANN NPLLSSKARS TSSHGRRPLI RQDRIVGVPL ELEQSTHRHT PETEVPPSNP
WQNWTRTPSP FEDRTAFPSK LETTPTTSPL PERKEHIKES TEIPSPFSPG VPWEYHDSNP
NRSLSNVFSQ IHCRPDSSKG VISISKSTER LSPLMKDIKS NKFKKSQSID EIDIGTYKVY
NIPLENYATG SDHLGSHERP DKMLGPEHGM SSMSRSQSVP MLDDEMLTYG SSKGPQQQKA
SMTKKVYQFD QSFNPQGAVE VKAEKRIPPP FQHNSEYVQQ PGKNIAKDLV SPRAYRGYPP
VEQMFSFSQP SVNEDAVVNA QFASQGARAG FLRRADSLAS STEMAMFRRV SEPHELTPSD
RYGRPPYRGG LDRQSSVSVT ESQFLKRNGR YEDEHPSYQE VKAQAGSFPV KNLTQRRPLS
ARSYSTESYG ASQTRPVSAR PTMAALLEKI PSDYNLGNYG DKPSDNSDIK TRPTPVKGEE
SCGKMPADWR QQLLRHIEAR RLDRNAAYKH NTVNLGMLPY GGISAMHAGR SMTLNLQTKS
KFDLQELPLQ KTPSQQSNIL DNGQEDVSPS GQWNPYPLGR RDVPPDTITK KAGSHIQTLM
GSQSLQHRSR EQQPYEGNVN KVTIQQFQSP LPIQIPSSQA TRGPQPGRCL IQTKGQRSMD
GYPEQFCVRI EKNPGLGFSI SGGISGQGNP FKPSDKGIFV TRVQPDGPAS NLLQPGDKIL
QANGHSFVHM EHEKAVLLLK SFQNTVDLVI QRELTV
