LRRC7_HUMAN
ID LRRC7_HUMAN Reviewed; 1537 AA.
AC Q96NW7; Q5VXC2; Q5VXC3; Q68D07; Q86VE8; Q8WX20; Q9P2I2;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Leucine-rich repeat-containing protein 7;
DE AltName: Full=Densin-180;
DE Short=Densin;
DE AltName: Full=Protein LAP1;
GN Name=LRRC7; Synonyms=KIAA1365, LAP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, AND
RP INTERACTION WITH CTNND2.
RX PubMed=11729199; DOI=10.1074/jbc.m110052200;
RA Izawa I., Nishizawa M., Ohtakara K., Inagaki M.;
RT "Densin-180 interacts with delta-catenin/neural plakophilin-related
RT armadillo repeat protein at synapses.";
RL J. Biol. Chem. 277:5345-5350(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=12525888;
RA Wang L., Xu J., Wu Q., Dai J., Ye X., Zeng L., Ji C., Gu S., Zhao R.C.,
RA Xie Y., Mao Y.;
RT "Cloning and characterization of a novel splice variant of the brain-
RT specific protein densin-180.";
RL Int. J. Mol. Med. 11:257-260(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-1537 (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 641-1537 (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [6]
RP INTERACTION WITH CAMK2A.
RX PubMed=28130356; DOI=10.1523/jneurosci.2068-16.2017;
RA Stephenson J.R., Wang X., Perfitt T.L., Parrish W.P., Shonesy B.C.,
RA Marks C.R., Mortlock D.P., Nakagawa T., Sutcliffe J.S., Colbran R.J.;
RT "Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and
RT Causes ASD-Related Behaviors.";
RL J. Neurosci. 37:2216-2233(2017).
RN [7]
RP VARIANT [LARGE SCALE ANALYSIS] MET-235.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Required for normal synaptic spine architecture and function.
CC Necessary for DISC1 and GRM5 localization to postsynaptic density
CC complexes and for both N-methyl D-aspartate receptor-dependent and
CC metabotropic glutamate receptor-dependent long term depression.
CC {ECO:0000269|PubMed:11729199}.
CC -!- SUBUNIT: Interacts with CNKSR2 and DLG4 (By similarity). Interacts with
CC CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2
CC (PubMed:11729199). Interacts with CAMK2A (PubMed:28130356).
CC {ECO:0000250|UniProtKB:P70587, ECO:0000269|PubMed:11729199,
CC ECO:0000269|PubMed:28130356}.
CC -!- INTERACTION:
CC Q96NW7; Q9Z1T4: Cnksr2; Xeno; NbExp=2; IntAct=EBI-524275, EBI-8548356;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11729199}.
CC Postsynaptic density {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96NW7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96NW7-2; Sequence=VSP_010797;
CC Name=3; Synonyms=LRRC7;
CC IsoId=Q96NW7-3; Sequence=VSP_010795, VSP_010796;
CC -!- TISSUE SPECIFICITY: Brain-specific. Isoform 3 is ubiquitously
CC expressed. {ECO:0000269|PubMed:12525888}.
CC -!- SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP06801.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA92603.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF434715; AAL28133.1; -; mRNA.
DR EMBL; AF498274; AAP06801.1; ALT_INIT; mRNA.
DR EMBL; AL117353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL157948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL158840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL359412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL391728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR749629; CAH18423.1; -; mRNA.
DR EMBL; AB037786; BAA92603.1; ALT_FRAME; mRNA.
DR RefSeq; NP_065845.1; NM_020794.2.
DR PDB; 6X5G; X-ray; 1.85 A; B=797-818.
DR PDBsum; 6X5G; -.
DR AlphaFoldDB; Q96NW7; -.
DR SMR; Q96NW7; -.
DR BioGRID; 121610; 19.
DR CORUM; Q96NW7; -.
DR IntAct; Q96NW7; 11.
DR MINT; Q96NW7; -.
DR STRING; 9606.ENSP00000035383; -.
DR GlyGen; Q96NW7; 3 sites, 1 O-linked glycan (3 sites).
DR iPTMnet; Q96NW7; -.
DR PhosphoSitePlus; Q96NW7; -.
DR SwissPalm; Q96NW7; -.
DR BioMuta; LRRC7; -.
DR DMDM; 50401129; -.
DR EPD; Q96NW7; -.
DR jPOST; Q96NW7; -.
DR MassIVE; Q96NW7; -.
DR MaxQB; Q96NW7; -.
DR PaxDb; Q96NW7; -.
DR PeptideAtlas; Q96NW7; -.
DR PRIDE; Q96NW7; -.
DR ProteomicsDB; 77567; -. [Q96NW7-1]
DR ProteomicsDB; 77568; -. [Q96NW7-2]
DR ProteomicsDB; 77569; -. [Q96NW7-3]
DR UCSC; uc001dep.4; human. [Q96NW7-1]
DR GeneCards; LRRC7; -.
DR HGNC; HGNC:18531; LRRC7.
DR MIM; 614453; gene.
DR neXtProt; NX_Q96NW7; -.
DR PharmGKB; PA134879588; -.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; Q96NW7; -.
DR OrthoDB; 40683at2759; -.
DR PhylomeDB; Q96NW7; -.
DR TreeFam; TF351429; -.
DR PathwayCommons; Q96NW7; -.
DR Reactome; R-HSA-438066; Unblocking of NMDA receptors, glutamate binding and activation.
DR Reactome; R-HSA-442982; Ras activation upon Ca2+ influx through NMDA receptor.
DR Reactome; R-HSA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR Reactome; R-HSA-9609736; Assembly and cell surface presentation of NMDA receptors.
DR Reactome; R-HSA-9617324; Negative regulation of NMDA receptor-mediated neuronal transmission.
DR Reactome; R-HSA-9620244; Long-term potentiation.
DR SignaLink; Q96NW7; -.
DR SIGNOR; Q96NW7; -.
DR BioGRID-ORCS; 57554; 8 hits in 1067 CRISPR screens.
DR ChiTaRS; LRRC7; human.
DR GeneWiki; LRRC7; -.
DR GenomeRNAi; 57554; -.
DR Pharos; Q96NW7; Tbio.
DR PRO; PR:Q96NW7; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q96NW7; protein.
DR Genevisible; Q96NW7; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0043194; C:axon initial segment; IBA:GO_Central.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0030054; C:cell junction; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0035580; C:specific granule lumen; TAS:Reactome.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IBA:GO_Central.
DR GO; GO:0043113; P:receptor clustering; IBA:GO_Central.
DR GO; GO:0097120; P:receptor localization to synapse; IBA:GO_Central.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS51450; LRR; 15.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cytoplasm; Leucine-rich repeat;
KW Methylation; Phosphoprotein; Reference proteome; Repeat; Synapse.
FT CHAIN 1..1537
FT /note="Leucine-rich repeat-containing protein 7"
FT /id="PRO_0000188298"
FT REPEAT 23..44
FT /note="LRR 1"
FT REPEAT 47..68
FT /note="LRR 2"
FT REPEAT 70..91
FT /note="LRR 3"
FT REPEAT 93..114
FT /note="LRR 4"
FT REPEAT 116..137
FT /note="LRR 5"
FT REPEAT 139..161
FT /note="LRR 6"
FT REPEAT 162..183
FT /note="LRR 7"
FT REPEAT 185..206
FT /note="LRR 8"
FT REPEAT 208..229
FT /note="LRR 9"
FT REPEAT 231..253
FT /note="LRR 10"
FT REPEAT 254..275
FT /note="LRR 11"
FT REPEAT 277..298
FT /note="LRR 12"
FT REPEAT 300..321
FT /note="LRR 13"
FT REPEAT 323..344
FT /note="LRR 14"
FT REPEAT 346..367
FT /note="LRR 15"
FT REPEAT 369..391
FT /note="LRR 16"
FT REPEAT 392..413
FT /note="LRR 17"
FT DOMAIN 1445..1535
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 663..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..759
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1331..1352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 439
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 441
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70587"
FT MOD_RES 443
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 831
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 850
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 865
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 869
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 947
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 949
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 1118
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 1149
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 1233
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT MOD_RES 1335
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70587"
FT MOD_RES 1439
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80TE7"
FT VAR_SEQ 178..179
FT /note="KS -> NI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12525888"
FT /id="VSP_010795"
FT VAR_SEQ 180..1537
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12525888"
FT /id="VSP_010796"
FT VAR_SEQ 1286..1332
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10718198"
FT /id="VSP_010797"
FT VARIANT 235
FT /note="L -> M (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035715"
FT VARIANT 1054
FT /note="H -> Y (in dbSNP:rs12069888)"
FT /id="VAR_049727"
FT CONFLICT 373
FT /note="L -> P (in Ref. 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1537 AA; 172581 MW; 1EB99AF133CD2925 CRC64;
MTTKRKIIGR LVPCRCFRGE EEIISVLDYS HCSLQQVPKE VFNFERTLEE LYLDANQIEE
LPKQLFNCQA LRKLSIPDND LSNLPTTIAS LVNLKELDIS KNGVQEFPEN IKCCKCLTII
EASVNPISKL PDGFTQLLNL TQLYLNDAFL EFLPANFGRL VKLRILELRE NHLKTLPKSM
HKLAQLERLD LGNNEFGELP EVLDQIQNLR ELWMDNNALQ VLPGSIGKLK MLVYLDMSKN
RIETVDMDIS GCEALEDLLL SSNMLQQLPD SIGLLKKLTT LKVDDNQLTM LPNTIGNLSL
LEEFDCSCNE LESLPSTIGY LHSLRTLAVD ENFLPELPRE IGSCKNVTVM SLRSNKLEFL
PEEIGQMQKL RVLNLSDNRL KNLPFSFTKL KELAALWLSD NQSKALIPLQ TEAHPETKQR
VLTNYMFPQQ PRGDEDFQSD SDSFNPTLWE EQRQQRMTVA FEFEDKKEDD ENAGKVKDLS
CQAPWERGQR GITLQPARLS GDCCTPWARC DQQIQDMPVP QNDPQLAWGC ISGLQQERSM
CTPLPVAAQS TTLPSLSGRQ VEINLKRYPT PYPEDLKNMV KSVQNLVGKP SHGVRVENSN
PTANTEQTVK EKYEHKWPVA PKEITVEDSF VHPANEMRIG ELHPSLAETP LYPPKLVLLG
KDKKESTDES EVDKTHCLNN SVSSGTYSDY SPSQASSGSS NTRVKVGSLQ TTAKDAVHNS
LWGNRIAPSF PQPLDSKPLL SQREAVPPGN IPQRPDRLPM SDTFTDNWTD GSHYDNTGFV
AEETTAENAN SNPLLSSKSR STSSHGRRPL IRQDRIVGVP LELEQSTHRH TPETEVPPSN
PWQNWTRTPS PFEDRTAFPS KLETTPTTSP LPERKEHIKE STEIPSPFSP GVPWEYHDSN
PNRSLSNVFS QIHCRPESSK GVISISKSTE RLSPLMKDIK SNKFKKSQSI DEIDIGTYKV
YNIPLENYAS GSDHLGSHER PDKMLGPEHG MSSMSRSQSV PMLDDEMLTY GSSKGPQQQK
ASMTKKVYQF DQSFNPQGSV EVKAEKRIPP PFQHNPEYVQ QASKNIAKDL ISPRAYRGYP
PMEQMFSFSQ PSVNEDAVVN AQFASQGARA GFLRRADSLV SATEMAMFRR VNEPHELPPT
DRYGRPPYRG GLDRQSSVTV TESQFLKRNG RYEDEHPSYQ EVKAQAGSFP VKNLTQRRPL
SARSYSTESY GASQTRPVSA RPTMAALLEK IPSDYNLGNY GDKPSDNSDL KTRPTPVKGE
ESCGKMPADW RQQLLRHIEA RRLDRNAAYK HNTVNLGMLP YGGISAMHAG RSMTLNLQTK
SKFDHQELPL QKTPSQQSNI LDNGQEDVSP SGQWNPYPLG RRDVPPDTIT KKAGSHIQTL
MGSQSLQHRS REQQPYEGNI NKVTIQQFQS PLPIQIPSSQ ATRGPQPGRC LIQTKGQRSM
DGYPEQFCVR IEKNPGLGFS ISGGISGQGN PFKPSDKGIF VTRVQPDGPA SNLLQPGDKI
LQANGHSFVH MEHEKAVLLL KSFQNTVDLV IQRELTV
