LRRC9_HUMAN
ID LRRC9_HUMAN Reviewed; 1453 AA.
AC Q6ZRR7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Leucine-rich repeat-containing protein 9;
GN Name=LRRC9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZRR7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZRR7-2; Sequence=VSP_033990, VSP_033991;
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DR EMBL; AK128037; BAC87242.1; -; mRNA.
DR EMBL; AL133299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL157911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q6ZRR7; -.
DR SMR; Q6ZRR7; -.
DR IntAct; Q6ZRR7; 1.
DR STRING; 9606.ENSP00000454748; -.
DR iPTMnet; Q6ZRR7; -.
DR PhosphoSitePlus; Q6ZRR7; -.
DR BioMuta; LRRC9; -.
DR DMDM; 189028874; -.
DR EPD; Q6ZRR7; -.
DR jPOST; Q6ZRR7; -.
DR PaxDb; Q6ZRR7; -.
DR PeptideAtlas; Q6ZRR7; -.
DR PRIDE; Q6ZRR7; -.
DR Antibodypedia; 72204; 6 antibodies from 3 providers.
DR Ensembl; ENST00000254271.8; ENSP00000454848.1; ENSG00000131951.11. [Q6ZRR7-2]
DR Ensembl; ENST00000445360.5; ENSP00000454748.1; ENSG00000131951.11. [Q6ZRR7-1]
DR UCSC; uc001xep.2; human. [Q6ZRR7-1]
DR GeneCards; LRRC9; -.
DR HGNC; HGNC:19848; LRRC9.
DR HPA; ENSG00000131951; Group enriched (brain, choroid plexus, testis).
DR neXtProt; NX_Q6ZRR7; -.
DR OpenTargets; ENSG00000131951; -.
DR VEuPathDB; HostDB:ENSG00000131951; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00940000158583; -.
DR HOGENOM; CLU_002627_0_0_1; -.
DR InParanoid; Q6ZRR7; -.
DR PhylomeDB; Q6ZRR7; -.
DR TreeFam; TF329042; -.
DR PathwayCommons; Q6ZRR7; -.
DR SignaLink; Q6ZRR7; -.
DR ChiTaRS; LRRC9; human.
DR Pharos; Q6ZRR7; Tdark.
DR PRO; PR:Q6ZRR7; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q6ZRR7; protein.
DR Bgee; ENSG00000131951; Expressed in testis and 79 other tissues.
DR ExpressionAtlas; Q6ZRR7; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR Gene3D; 3.80.10.10; -; 8.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 11.
DR PROSITE; PS51450; LRR; 24.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..1453
FT /note="Leucine-rich repeat-containing protein 9"
FT /id="PRO_0000337676"
FT REPEAT 53..78
FT /note="LRR 1"
FT REPEAT 97..119
FT /note="LRR 2"
FT REPEAT 120..141
FT /note="LRR 3"
FT REPEAT 142..164
FT /note="LRR 4"
FT REPEAT 166..188
FT /note="LRR 5"
FT REPEAT 224..248
FT /note="LRR 6"
FT REPEAT 264..287
FT /note="LRR 7"
FT REPEAT 344..367
FT /note="LRR 8"
FT REPEAT 671..693
FT /note="LRR 9"
FT REPEAT 694..715
FT /note="LRR 10"
FT REPEAT 716..737
FT /note="LRR 11"
FT REPEAT 739..758
FT /note="LRR 12"
FT REPEAT 759..784
FT /note="LRR 13"
FT REPEAT 786..812
FT /note="LRR 14"
FT REPEAT 886..908
FT /note="LRR 15"
FT REPEAT 909..930
FT /note="LRR 16"
FT REPEAT 931..952
FT /note="LRR 17"
FT REPEAT 953..975
FT /note="LRR 18"
FT REPEAT 976..1001
FT /note="LRR 19"
FT REPEAT 1023..1048
FT /note="LRR 20"
FT REPEAT 1092..1115
FT /note="LRR 21"
FT REPEAT 1116..1138
FT /note="LRR 22"
FT REPEAT 1139..1161
FT /note="LRR 23"
FT REPEAT 1201..1224
FT /note="LRR 24"
FT REPEAT 1225..1247
FT /note="LRR 25"
FT REPEAT 1248..1270
FT /note="LRR 26"
FT REPEAT 1272..1292
FT /note="LRR 27"
FT REPEAT 1293..1317
FT /note="LRR 28"
FT REPEAT 1319..1345
FT /note="LRR 29"
FT REPEAT 1365..1388
FT /note="LRR 30"
FT REGION 302..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1106..1111
FT /note="RTVDLI -> SCIYFV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033990"
FT VAR_SEQ 1112..1453
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033991"
FT CONFLICT 87
FT /note="C -> R (in Ref. 1; BAC87242)"
FT /evidence="ECO:0000305"
FT CONFLICT 629
FT /note="A -> P (in Ref. 1; BAC87242)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1453 AA; 166911 MW; 656BD856392E18C5 CRC64;
MIESENLNQE EIIKELCLCN GLSYEMVGQE GSDTSKLEMF FLGYPRIVGL SLFPNLTSLT
IVAQDIKEIS GLEPCLQLKE LWIAECCIEK IEGLQECRNL EKLYLYFNKI SKIENLEKLI
KLKVLWLNHN TIKNIEGLQT LKNLKDLNLA GNLINSIGRC LDSNEQLERL NLSGNQICSF
KELTNLTRLP CLKDLCLNDP QYTTNPVCLL CNYSTHVLYH LPCLQRFDTL DVSAKQIKEL
ADTTAMKKIM YYNMRIKTLQ RHLKEDLEKL NDQKCKLQKL PEERVKLFSF VKKTLERELA
ELKGSGKGHS DGSNNSKVTD PETLKSCETV TEEPSLQQKI LAKLNALNER VTFWNKKLDE
IEAIYHIEVK QKKKSHGLLI PLLLIELETV GNFHFEEGTR SDDWFNFCYE LILSRFCAWD
FRTYGITGVK VKRIIKVNNR ILRLKFEEKF QKFLENEDMH DSESYRRMLE CLFYVFDPEV
SVKKKHLLQI LEKGFKDSET SKLPLKKEAI IVSNSLSISE CPRIEFLQQK HKDEKKISLK
HELFRHGILL ITKVFLGQSV QAHEKESISQ SNYPMVNSVF IPRKYLLNSV MGQRNCDCSV
RQCKWFVFDH DLVLPEYVVE FEYITMVKAP SLFSVFNNVI LEESKKNPEV SVFSKDLKFD
DEVIKMEPRI KARPKLISLD DKTILSLAKT SVYSHIVSLN LHGNSLSKLR DLSKLTGLRK
LNISFNEFTC LDDVYHLYNL EYLDASHNHV ITLEGFRGLM KLKHLDLSWN QLKKSGNEIN
MLCKHTTSLL TLDIQHNPWQ KPATLRLSVI GRLKTLTHLN GVFISEEEAT AAMKFIAGTR
ITQLSLLRHS STKEERPRIL SIWPSAKILT QVSKLGPHLH LSGNCYLKIT ALNLDGQHLF
EITNLEKLEN LKWASFSNNN LTKMEGLESC INLEELTLDG NCISKIEGIS KMTKLTRLSI
NNNLLTGWEE HTFDNMLHLH SLSLENNRIT SLSGLQKSFT LVELYISNNY IAVNQEMHNL
KGLCNLVILD MCGNIIIWNQ ENYRLFVIFH LPELKALDGI PIEPSETDSA KDLFGGRLTS
DMIAERQGHS NFKQMQELNW TSSSIRTVDL IPVDQFRNVC NVNLQNNHLT SFSGLIYLPN
VKVLCLNYNH IESIMPRLKP QTHLTSRQLL YQKVPSSGYG QQGISKTNRD IMSSENLPPI
MHSLEVLHLG YNGICNLIQL QLNRLRNLKF LFLQGNEISQ VEGLDNLVVL QELVVDHNRI
RSFNDSAFAK PSSLLALHLE ENRLRELGKL QSLVKLEKLF LGYNKIQDIT ELEKLDVIST
LRELTVYGNP ICRKMLHRHM LIFRLPNLQM LDGSPVNSDD RAKAEFHLAE LQAKKNSLIP
VTHSPMDGRS FGQVKTPPIE ITNVLLPSGF SHYLGSDVTL TPEVEEFLGA TFQDQIECNC
LKRNEHTPRN SPV
