LRRC9_MOUSE
ID LRRC9_MOUSE Reviewed; 1456 AA.
AC Q8CDN9; Q8CAD3; Q9D2J8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Leucine-rich repeat-containing protein 9;
GN Name=Lrrc9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-525, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15592455; DOI=10.1038/nbt1046;
RA Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,
RA Zha X.-M., Polakiewicz R.D., Comb M.J.;
RT "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
RL Nat. Biotechnol. 23:94-101(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CDN9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CDN9-2; Sequence=VSP_033992, VSP_033993;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB31790.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC26622.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK019545; BAB31790.1; ALT_FRAME; mRNA.
DR EMBL; AK029802; BAC26622.1; ALT_FRAME; mRNA.
DR EMBL; AK039037; BAC30215.2; -; mRNA.
DR CCDS; CCDS49085.1; -. [Q8CDN9-1]
DR RefSeq; NP_001136200.1; NM_001142728.1. [Q8CDN9-1]
DR RefSeq; NP_001136201.1; NM_001142729.1.
DR RefSeq; NP_084346.2; NM_030070.3.
DR RefSeq; XP_017170735.1; XM_017315246.1. [Q8CDN9-1]
DR AlphaFoldDB; Q8CDN9; -.
DR SMR; Q8CDN9; -.
DR STRING; 10090.ENSMUSP00000124394; -.
DR iPTMnet; Q8CDN9; -.
DR PhosphoSitePlus; Q8CDN9; -.
DR PaxDb; Q8CDN9; -.
DR PRIDE; Q8CDN9; -.
DR ProteomicsDB; 292114; -. [Q8CDN9-1]
DR ProteomicsDB; 292115; -. [Q8CDN9-2]
DR Antibodypedia; 72204; 6 antibodies from 3 providers.
DR DNASU; 78257; -.
DR Ensembl; ENSMUST00000162159; ENSMUSP00000124394; ENSMUSG00000021090. [Q8CDN9-1]
DR GeneID; 78257; -.
DR KEGG; mmu:78257; -.
DR UCSC; uc007nvn.2; mouse. [Q8CDN9-1]
DR CTD; 341883; -.
DR MGI; MGI:1925507; Lrrc9.
DR VEuPathDB; HostDB:ENSMUSG00000021090; -.
DR eggNOG; KOG0531; Eukaryota.
DR GeneTree; ENSGT00940000158583; -.
DR HOGENOM; CLU_002627_0_0_1; -.
DR InParanoid; Q8CDN9; -.
DR OMA; QEMYNLK; -.
DR OrthoDB; 994469at2759; -.
DR PhylomeDB; Q8CDN9; -.
DR TreeFam; TF329042; -.
DR BioGRID-ORCS; 78257; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Lrrc9; mouse.
DR PRO; PR:Q8CDN9; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8CDN9; protein.
DR Bgee; ENSMUSG00000021090; Expressed in spermatid and 35 other tissues.
DR ExpressionAtlas; Q8CDN9; baseline and differential.
DR Genevisible; Q8CDN9; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; -; 7.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00446; LRRcap; 3.
DR PROSITE; PS51450; LRR; 25.
PE 1: Evidence at protein level;
KW Alternative splicing; Leucine-rich repeat; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..1456
FT /note="Leucine-rich repeat-containing protein 9"
FT /id="PRO_0000337677"
FT REPEAT 53..78
FT /note="LRR 1"
FT REPEAT 97..119
FT /note="LRR 2"
FT REPEAT 120..141
FT /note="LRR 3"
FT REPEAT 142..164
FT /note="LRR 4"
FT REPEAT 166..188
FT /note="LRR 5"
FT REPEAT 190..212
FT /note="LRR 6"
FT REPEAT 224..248
FT /note="LRR 7"
FT REPEAT 264..287
FT /note="LRR 8"
FT REPEAT 339..362
FT /note="LRR 9"
FT REPEAT 661..683
FT /note="LRR 10"
FT REPEAT 684..705
FT /note="LRR 11"
FT REPEAT 706..727
FT /note="LRR 12"
FT REPEAT 729..748
FT /note="LRR 13"
FT REPEAT 749..772
FT /note="LRR 14"
FT REPEAT 776..802
FT /note="LRR 15"
FT REPEAT 806..833
FT /note="LRR 16"
FT REPEAT 876..898
FT /note="LRR 17"
FT REPEAT 899..920
FT /note="LRR 18"
FT REPEAT 921..942
FT /note="LRR 19"
FT REPEAT 943..965
FT /note="LRR 20"
FT REPEAT 967..991
FT /note="LRR 21"
FT REPEAT 993..1010
FT /note="LRR 22"
FT REPEAT 1013..1037
FT /note="LRR 23"
FT REPEAT 1082..1105
FT /note="LRR 24"
FT REPEAT 1106..1128
FT /note="LRR 25"
FT REPEAT 1129..1151
FT /note="LRR 26"
FT REPEAT 1191..1214
FT /note="LRR 27"
FT REPEAT 1215..1237
FT /note="LRR 28"
FT REPEAT 1238..1260
FT /note="LRR 29"
FT REPEAT 1262..1283
FT /note="LRR 30"
FT REPEAT 1284..1307
FT /note="LRR 31"
FT REPEAT 1309..1335
FT /note="LRR 32"
FT REGION 305..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 525
FT /note="Phosphotyrosine"
FT /evidence="ECO:0007744|PubMed:15592455"
FT VAR_SEQ 1133..1154
FT /note="VLCLNYNHIESIMPRLKPQTHL -> ARGCRAIFALKDISTSFNLHLH (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033992"
FT VAR_SEQ 1155..1456
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_033993"
FT CONFLICT 173
FT /note="S -> F (in Ref. 1; BAC30215)"
FT /evidence="ECO:0000305"
FT CONFLICT 293
FT /note="K -> R (in Ref. 1; BAC30215)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="T -> K (in Ref. 1; BAC30215)"
FT /evidence="ECO:0000305"
FT CONFLICT 364
FT /note="V -> A (in Ref. 1; BAC30215)"
FT /evidence="ECO:0000305"
FT CONFLICT 458
FT /note="D -> ES (in Ref. 1; BAB31790)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1456 AA; 167302 MW; C5B99D6C9CBDAE41 CRC64;
MIESENLNRG EIIKELCLCN GLTYEIVGQE GSDTSKLEMF FSGYPRIVGL SLFHNLSSLT
IVAQDIREIS GLETCLQLKE LWIAECCIEK IEGLQGCRNL EKLYLYYNKI SKIENLEKLI
KLEVLWLNHN MIKNIEGLQT LKNLKDLNLA GNLVSSIGRC LDPNEQLEKL NLSGNQITSF
KDLTNLTKLT RLKDLCLNDP QYKSNPVCQL CNYSTHVLYH LPSLQRLDTF DVSAKQIKEL
ADSTAMKKIM YYNMRIKTVQ RHLNEELEKL NDRKCKLQKL PEERIKLFNF AKKTLERELA
ELKISSKGQS DTTPEAEKPR NSEVVTQESV LQQKILTKLS ALDDRVTFWN KKLHEIEAIY
RTEVKQKKKT HGLLTPFLLT ELETVGNIHF EEGTQADDWF NSCCELILSR FCTWDFRAYG
ITGVKVKRVI KVNNRILRLK FEEKFQKCLD LEDTQDPDYR KMLECLFYVF DPEVTVKKKH
LLQILERGFK DSDTSKPSLK KEAVTLVNSL SMCECPRIEF LQQKYKEEKK GPSESELYRH
GTILIAKVFL GQSIQARDQE PINKANYPMV NSVFVPQRHV LRQRTCDCGY RQYKWFVFDH
DLVLPEYIVE FEYTTVVKVH SLFSTSNNVI LEEGKKYSEG LVFSQDLKFD DEVLKMEPRI
KPRPKLISLD EKTIISLAKT NIYSHIVNLN LHGNSLSKLR DLAKLTGLRK LNISFNEFTC
LDDVYHLYNL EYLDASHNHV ITLEGFRGLM KLKHLDLSWN QLKKTGEEIN VLCKHTTSLL
TLDIQHNPWQ KPATLRLSVI GRLKTLTHLD GLVISEEETR AALKFISGTK ITQLTLLQHS
SSKEERPRML STWPSAKILT QISKLGPHFH LTGNWYSKIT ALNLDGQHLF EITNLEKLEN
LKWASFSNNN LSKMEGLESC VNLEELTLDG NCISKIEGIT RLTKLSRLSM NNNLLTGLEK
HTFDNLLHLH SLSLENNRIT SLSALQKTFT LIELYISNNY IAVNQEIYNL KGLCNLVILD
MYGNIIIWNQ ENYRFFVIFH LPELKALDGV SIETSETETA KDLFGGRLTS DMIAERQGHS
NFIQMQELNW TSSAIRTVDL IPVDHFRNVS NVNLQNNNLT SFSGLIYLPN VKVLCLNYNH
IESIMPRLKP QTHLSSRQLL YQKVPSSGYG QQGTSKLNRD SVGSENLPPI MQSLEVLHLG
YNGICNLVQL QLNRLRNLKF LFLQGNEISQ VEGLDNLIVL QELVVDHNRI RAFNDTAFSK
PSSLLMLHLE ENRLRELSKL QSLVKLEKLF LGYNKIQDIT ELEKLDVIPS LRELTVYGNP
ICRKMVHRHV LIFRLPNLQM LDGIPINSDD RAKAEFHFSE LQAKKSSIIQ NNLPTSKSSL
PSHLQTPLPC KFVPVTNSTD GGSFCHVKAS PIKITNVLLP AGFSRFLGPD FTLTPEVEGI
FTKSFRENEK TNKQQQ
