ID   LRRD1_MACFA             Reviewed;         863 AA.
AC   Q4R6F0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Leucine-rich repeat and death domain-containing protein 1;
GN   Name=LRRD1; ORFNames=QtsA-18164;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB169234; BAE01325.1; -; mRNA.
DR   RefSeq; NP_001270297.1; NM_001283368.1.
DR   AlphaFoldDB; Q4R6F0; -.
DR   SMR; Q4R6F0; -.
DR   STRING; 9541.XP_005550298.1; -.
DR   GeneID; 101865257; -.
DR   CTD; 401387; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   OrthoDB; 826997at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.80.10.10; -; 3.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 4.
DR   SMART; SM00369; LRR_TYP; 14.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS51450; LRR; 22.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..863
FT                   /note="Leucine-rich repeat and death domain-containing
FT                   protein 1"
FT                   /id="PRO_0000325805"
FT   REPEAT          143..166
FT                   /note="LRR 1"
FT   REPEAT          167..189
FT                   /note="LRR 2"
FT   REPEAT          190..213
FT                   /note="LRR 3"
FT   REPEAT          214..236
FT                   /note="LRR 4"
FT   REPEAT          238..259
FT                   /note="LRR 5"
FT   REPEAT          260..282
FT                   /note="LRR 6"
FT   REPEAT          284..305
FT                   /note="LRR 7"
FT   REPEAT          306..328
FT                   /note="LRR 8"
FT   REPEAT          329..351
FT                   /note="LRR 9"
FT   REPEAT          353..374
FT                   /note="LRR 10"
FT   REPEAT          375..397
FT                   /note="LRR 11"
FT   REPEAT          398..420
FT                   /note="LRR 12"
FT   REPEAT          422..443
FT                   /note="LRR 13"
FT   REPEAT          445..466
FT                   /note="LRR 14"
FT   REPEAT          468..489
FT                   /note="LRR 15"
FT   REPEAT          490..513
FT                   /note="LRR 16"
FT   REPEAT          515..535
FT                   /note="LRR 17"
FT   REPEAT          536..558
FT                   /note="LRR 18"
FT   REPEAT          560..581
FT                   /note="LRR 19"
FT   REPEAT          582..604
FT                   /note="LRR 20"
FT   REPEAT          606..627
FT                   /note="LRR 21"
FT   REPEAT          630..653
FT                   /note="LRR 22"
FT   REPEAT          654..676
FT                   /note="LRR 23"
FT   REPEAT          678..699
FT                   /note="LRR 24"
FT   REPEAT          700..722
FT                   /note="LRR 25"
FT   REPEAT          724..745
FT                   /note="LRR 26"
FT   DOMAIN          767..855
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   REPEAT          856..863
FT                   /note="LRR 27"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   863 AA;  98570 MW;  F777BBD41E65A6B7 CRC64;
     MSEKEGMSEE LEDTISQFRK ESRSQSVKEP GFIKETSNLI NEASDYLEGK SSNQIYETHP
     RQITLESTSS SGSKSKRNEE QKKNLQFSET STRTETSQSL SSLTGRIAEY QALVNFLSHE
     TVGEVSPQVS EENQKHLGLE TTCKDNFTVN LEAKGLQEFP KDILKIKYVK HLYLDKNQIK
     TFQGADSGDL LGLEILSLQE NGLSSLPSEI QLLHNLRILN VSHNHISHIP KEISQLGNIR
     QLFFYNNYIE NFPSDLECLG NLEILSLGKN KLRHIPDTLP SLKYLRVLNL EYNQLTIFPK
     ALCFLPKLIS LDLTGNLISS LPKEIRELKN LETLLLDHNK LTFLAVEIFQ LLKIKELQLA
     DNKLEVISHK IENFRELRIL ILDKNLLKNI PEKICCCAML ECLTLSDNKL TELPKNIHKL
     NNLRKLHVNR NNMVKITDSI SHLNNICSLE FSGNIIAGIP IEIKNCQKII KIELNYNKIM
     YFPLGLCALD SLYYLSVNGN YISEIPADIS FSKQLLHLEL SENKLLIFSE HFCSLINLKY
     LDLGKNQIKK IPASISNMIS LHVLILCCNK FETFPRELCT LENLRVLDLS ENQLQKISSD
     ICNLKRIQKL NFSSNQFIHF PIELCQLQSL EQLNISQIKG RKLTRLPGEL SNMTQLKELD
     ISNNAIREIP RNIGELRNLV SLHAYNNQIS YIPPSLLSLN DLQQLNLSGN NLTALPSAIY
     NLFSLKEINF DDNPLLRPPM EICKGKQLYT IARYLQRADE RDEKILEKIF KIVANNITET
     NFEFLCQKLN LANSETDMPT KSTVSLSERA HQALVIWKTQ SNKLSLTAAA LRDQLIRALT
     MIGAYEIMDK ITALNLFTRA IKF