LRRD1_MOUSE
ID LRRD1_MOUSE Reviewed; 853 AA.
AC Q8C0R9; B2RU96;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Leucine-rich repeat and death domain-containing protein 1;
GN Name=Lrrd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK029981; BAC26715.1; -; mRNA.
DR EMBL; BC141026; AAI41027.1; -; mRNA.
DR EMBL; BC145170; AAI45171.1; -; mRNA.
DR CCDS; CCDS19068.1; -.
DR RefSeq; NP_766467.2; NM_172879.3.
DR AlphaFoldDB; Q8C0R9; -.
DR SMR; Q8C0R9; -.
DR iPTMnet; Q8C0R9; -.
DR PhosphoSitePlus; Q8C0R9; -.
DR PaxDb; Q8C0R9; -.
DR PeptideAtlas; Q8C0R9; -.
DR PRIDE; Q8C0R9; -.
DR ProteomicsDB; 292116; -.
DR Antibodypedia; 58070; 1 antibodies from 1 providers.
DR DNASU; 242838; -.
DR Ensembl; ENSMUST00000044039; ENSMUSP00000038675; ENSMUSG00000040367.
DR GeneID; 242838; -.
DR KEGG; mmu:242838; -.
DR UCSC; uc008whx.2; mouse.
DR CTD; 401387; -.
DR MGI; MGI:3045299; Lrrd1.
DR VEuPathDB; HostDB:ENSMUSG00000040367; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161427; -.
DR HOGENOM; CLU_022747_0_0_1; -.
DR InParanoid; Q8C0R9; -.
DR OMA; NFNGNYI; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q8C0R9; -.
DR TreeFam; TF351429; -.
DR BioGRID-ORCS; 242838; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q8C0R9; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8C0R9; protein.
DR Bgee; ENSMUSG00000040367; Expressed in spermatid and 10 other tissues.
DR ExpressionAtlas; Q8C0R9; baseline and differential.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 6.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00369; LRR_TYP; 19.
DR PROSITE; PS51450; LRR; 22.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..853
FT /note="Leucine-rich repeat and death domain-containing
FT protein 1"
FT /id="PRO_0000325806"
FT REPEAT 133..157
FT /note="LRR 1"
FT REPEAT 159..180
FT /note="LRR 2"
FT REPEAT 183..204
FT /note="LRR 3"
FT REPEAT 206..227
FT /note="LRR 4"
FT REPEAT 229..251
FT /note="LRR 5"
FT REPEAT 252..274
FT /note="LRR 6"
FT REPEAT 275..297
FT /note="LRR 7"
FT REPEAT 298..319
FT /note="LRR 8"
FT REPEAT 321..342
FT /note="LRR 9"
FT REPEAT 344..365
FT /note="LRR 10"
FT REPEAT 367..388
FT /note="LRR 11"
FT REPEAT 390..411
FT /note="LRR 12"
FT REPEAT 413..435
FT /note="LRR 13"
FT REPEAT 436..457
FT /note="LRR 14"
FT REPEAT 459..481
FT /note="LRR 15"
FT REPEAT 482..503
FT /note="LRR 16"
FT REPEAT 505..527
FT /note="LRR 17"
FT REPEAT 528..549
FT /note="LRR 18"
FT REPEAT 551..573
FT /note="LRR 19"
FT REPEAT 574..596
FT /note="LRR 20"
FT REPEAT 597..618
FT /note="LRR 21"
FT REPEAT 620..641
FT /note="LRR 22"
FT REPEAT 646..668
FT /note="LRR 23"
FT REPEAT 669..690
FT /note="LRR 24"
FT REPEAT 692..713
FT /note="LRR 25"
FT REPEAT 715..736
FT /note="LRR 26"
FT DOMAIN 757..845
FT /note="Death"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 602
FT /note="N -> H (in Ref. 1; BAC26715)"
FT /evidence="ECO:0000305"
FT CONFLICT 618
FT /note="L -> R (in Ref. 1; BAC26715)"
FT /evidence="ECO:0000305"
FT CONFLICT 634
FT /note="L -> V (in Ref. 1; BAC26715)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 853 AA; 97132 MW; EC1B2E4CD23100E1 CRC64;
MSEDGSNVEP GGFPRFESLE EPGSEISDLL DEASPYSKSK DSNQIYEANP SKDTEQSAAS
FTSQLDRNEE KNTGIPFSET NIADIIPLSI EESLQSSGSS ETKMAEDYYP VKFPTGRKFR
GRIFNGNQKG LDMKSDNFTV NLDAKGLQEF PVDIVKVKYV KYLYLDKNQI KNFQGIDPGD
LLGLEILSLQ ENGLSSIPLE IQLFHNLKIL NASYNEISQI PKELLQLENM RQLLLNSNHI
DTLPSGLEHL RYLETLSLGK NMLTYIPDSL SSLKNLRILN LEYNQLTIFS KSLCFLPKLN
SLNLTGNMIG SLPKEVRELK NLESLLMDHN KLTFLAVEIF QLPKIKELHL ADNKLEAISP
KIENFKELRL LNLDKNLLQS IPKKISHCVN LESLSLSDNN IEELPKKIRK LKNLRQLHVN
RNKMITMTEE ISHLSNIHIL EFSGNQITHV PIEIKNCRKI TRVELNYNNI MYFPVGLCAL
QSLDYLSFNG NYISEIPVDM SFSKQLLHLE LNRNKLTVFS KHLCSLTNLE YLDLAKNQIM
TIPSCISAMV SLHVLILSDN KFESFPKELC SLKNLRVLDI SENKLQKIPL EISKLKRIQK
LNLSNNIFTN FPVELCQLQT LEELNISQTS GKKLTRLPEE VSHMTQLKIL NISNNAIKDI
PKNIGELRSL VSFYASNNQI SSLPSSFLSL EVLQSLDLRG NNMTALPSGI YKLSSLKEIN
FDDNPLMRPP MEICKGKEMH MITCYLQRAD ERDEKILEKI FNIVANSITE TNFEFLQQKL
NMASSANNMP VRPTTPLNER IYQALIKWKA EKDVQFTATA LRDKLFRALN MIGAYDIMDK
ITALNLYTSA IKL
