LRRF2_XENLA
ID LRRF2_XENLA Reviewed; 729 AA.
AC Q6GNW0;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 52.
DE RecName: Full=Leucine-rich repeat flightless-interacting protein 2;
DE Short=LRR FLII-interacting protein 2;
DE Short=xLRRFIP2;
GN Name=lrrfip2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=15677333; DOI=10.1073/pnas.0409472102;
RA Liu J., Bang A.G., Kintner C., Orth A.P., Chanda S.K., Ding S.,
RA Schultz P.G.;
RT "Identification of the Wnt signaling activator leucine-rich repeat in
RT Flightless interaction protein 2 by a genome-wide functional analysis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:1927-1932(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Tail bud;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May function as activator of the canonical Wnt signaling
CC pathway upstream of ctnnb1/beta-catenin. Might be required for dorsal
CC axis formation. {ECO:0000269|PubMed:15677333}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6GNW0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6GNW0-2; Sequence=VSP_035798, VSP_035799, VSP_035800;
CC -!- DEVELOPMENTAL STAGE: A shorter isoform, which probably corresponds to
CC isoform 2, is expressed both maternally and zygotically throughout
CC early development. Isoform 1 is expressed only after the mid-blastula
CC transition (MBT), becoming readily detectable after stage 14.
CC {ECO:0000269|PubMed:15677333}.
CC -!- SIMILARITY: Belongs to the LRRFIP family. {ECO:0000305}.
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DR EMBL; BC073391; AAH73391.1; -; mRNA.
DR RefSeq; NP_001085821.1; NM_001092352.1.
DR AlphaFoldDB; Q6GNW0; -.
DR SMR; Q6GNW0; -.
DR DNASU; 444248; -.
DR GeneID; 444248; -.
DR KEGG; xla:444248; -.
DR CTD; 444248; -.
DR Xenbase; XB-GENE-950915; lrrfip2.L.
DR OrthoDB; 1434475at2759; -.
DR Proteomes; UP000186698; Chromosome 6L.
DR Bgee; 444248; Expressed in zone of skin and 19 other tissues.
DR GO; GO:0030275; F:LRR domain binding; ISS:UniProtKB.
DR GO; GO:0009950; P:dorsal/ventral axis specification; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IMP:UniProtKB.
DR InterPro; IPR019139; LRRFIP1/2.
DR PANTHER; PTHR19212; PTHR19212; 1.
DR Pfam; PF09738; LRRFIP; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Developmental protein;
KW Reference proteome; Wnt signaling pathway.
FT CHAIN 1..729
FT /note="Leucine-rich repeat flightless-interacting protein
FT 2"
FT /id="PRO_0000245249"
FT REGION 80..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 27..69
FT /evidence="ECO:0000255"
FT COILED 357..531
FT /evidence="ECO:0000255"
FT COILED 574..722
FT /evidence="ECO:0000255"
FT COMPBIAS 92..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 60..294
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_035798"
FT VAR_SEQ 351..374
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_035799"
FT VAR_SEQ 465..529
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_035800"
FT CONFLICT 599
FT /note="K -> L (in Ref. 2; AAH73391)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 729 AA; 83500 MW; 9EC5FBC067BB1826 CRC64;
MGTPGSGRKR TQIKDRFSAE DEALSHIARE AEARLAAKRA ARAEARDIRM RELERQQKEL
THRYHDKKWG QIQKWMEDSD HARHLQRSSH RHSMASSRVT PNHRSSSVDV SGSHRGRESI
SRRRDSVYNT LKDSSRRTSN SYSNSYDVKN TTSSSHRDLL SGLYHDQRKY SSLKYNKPIS
THHIRSSSLY SEPLATKRTY GTSLYKDGLY NASSSRAPSE YSCYSSRASS ARSSPVCSDD
EGSVSYSSCR GRRDSVSSDF SDQSESAADY FSRSNRRGSI VSDVDDVSIP DLNSLDEKTD
KQFTTENYSR PSSRNATSGI PGTFTPLSGS SSRRGSGDAS CSLDPDASLS ELRDIYDLKD
QIQDVEGRYM QGLKELRESL AEVEEKYKKA MVSNAQLDNE KSNLVYHVDT LKDVIEEMEE
QMAEYHRENE EKSKELERQK HNCSILQHKL DEHKEGIRQR DEFIEENQRM QQRVDSLVRE
VYDLQETINW KDKKIGALER QKEYFDCIKN ERDELRDELT AVKEKVKIGE KHGLVIIPDG
TPNGDINHEP MVGAITVVSQ EAAHVLESAG EGPLDVRLRK LAEEKEELVA QIRKLKLQKD
DERQKSAKNN STTTDPTGLE NGSDLQLIEM QRDANRQISE YKFRLSKSEQ DITTLEQNVM
RLEGQVVRYK SAAENAEKVE DELKAEKRRL QRELRTALDK MEEMEMTNNH LVKRLEKMKA
NRTALLSQQ
