ID   LRRF2_XENTR             Reviewed;         404 AA.
AC   B2GUE2;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Leucine-rich repeat flightless-interacting protein 2 {ECO:0000250|UniProtKB:Q6GNW0};
DE            Short=LRR FLII-interacting protein 2;
GN   Name=lrrfip2 {ECO:0000250|UniProtKB:Q6GNW0};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAI66241.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:AAI66297.1}, and
RC   Testis {ECO:0000312|EMBL:AAI66241.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as an activator of the canonical Wnt signaling
CC       pathway upstream of ctnnb1/beta-catenin. May be required for dorsal
CC       axis formation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LRRFIP family. {ECO:0000255}.
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DR   EMBL; BC166241; AAI66241.1; -; mRNA.
DR   EMBL; BC166297; AAI66297.1; -; mRNA.
DR   RefSeq; NP_001121471.1; NM_001127999.1.
DR   AlphaFoldDB; B2GUE2; -.
DR   SMR; B2GUE2; -.
DR   GeneID; 100158569; -.
DR   KEGG; xtr:100158569; -.
DR   CTD; 9209; -.
DR   Xenbase; XB-GENE-950912; lrrfip2.
DR   HOGENOM; CLU_018871_0_0_1; -.
DR   InParanoid; B2GUE2; -.
DR   OrthoDB; 1434475at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0030275; F:LRR domain binding; ISS:UniProtKB.
DR   GO; GO:0009950; P:dorsal/ventral axis specification; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019139; LRRFIP1/2.
DR   PANTHER; PTHR19212; PTHR19212; 4.
DR   Pfam; PF09738; LRRFIP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Developmental protein; Reference proteome;
KW   Wnt signaling pathway.
FT   CHAIN           1..404
FT                   /note="Leucine-rich repeat flightless-interacting protein
FT                   2"
FT                   /id="PRO_0000355080"
FT   REGION          56..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          27..71
FT                   /evidence="ECO:0000255"
FT   COILED          110..199
FT                   /evidence="ECO:0000255"
FT   COILED          249..397
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        70..112
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   404 AA;  45985 MW;  60A280136AA26DF3 CRC64;
     MGTPGSGRKR TQIKDRFSAE DEALSHIARE AEARLAAKRA ARAEARDIRM RELERQQKEL
     DEKIDKQFTE NYSRPSSRNA TSGIPGTFTP LSGSSSRRGS GDANSSLDPD ASLSELRESL
     AEVEEKYKKA MVSNAQLDNE KSNLVYQVDT LKDVVEEMEE QMAEYHRENE EKSKELERQK
     HNCSILQHKL DELKEGIQQR DEFIEKHGLV IIPDGTPNGD INHEPVVGAI TVVSQEAAHV
     LESAGEGPLD VRLRKLAEEK EELVAQIRKL KLQLDDERQR SAKNNSTTTD STGLENGSDL
     QLIEMQRDAN RQISEYKFKI SKAEQDMTTL EQNVMRLEGQ VVRYKSAAEN AEKVEDELKA
     EKRRLQRELR TALDKMEEME MTNNHLVKRL EKMKANRTAL LSQQ