LRRN1_BOVIN
ID LRRN1_BOVIN Reviewed; 716 AA.
AC A0N0X6;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Leucine-rich repeat neuronal protein 1;
DE AltName: Full=Neuronal leucine-rich repeat protein 1;
DE Short=NLRR-1;
DE Flags: Precursor;
GN Name=LRRN1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Heaton M.P., Clawson M.L., Snelling W.M., Keele J.W., Harhay G.P.,
RA Wiedmann R.T., Bennett G.L., Smith T.P.L., Stone R.T., Freking B.A.,
RA Van Tassell C.P., Sonstegard T.S., Gasbarre L.C., Moore S.S., Murdoch B.,
RA McKay S.D., Kalbfleisch T., Laegreid W.W.;
RT "Estimating probability of parentage in U.S. beef and dairy cattle with
RT single nucleotide polymorphisms.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; EF093509; ABK35137.1; -; Genomic_DNA.
DR RefSeq; NP_001074207.1; NM_001080738.1.
DR RefSeq; XP_005222725.1; XM_005222668.3.
DR RefSeq; XP_005222726.1; XM_005222669.3.
DR AlphaFoldDB; A0N0X6; -.
DR SMR; A0N0X6; -.
DR STRING; 9913.ENSBTAP00000001560; -.
DR PaxDb; A0N0X6; -.
DR PRIDE; A0N0X6; -.
DR Ensembl; ENSBTAT00000001560; ENSBTAP00000001560; ENSBTAG00000001176.
DR GeneID; 539619; -.
DR KEGG; bta:539619; -.
DR CTD; 57633; -.
DR VEuPathDB; HostDB:ENSBTAG00000001176; -.
DR VGNC; VGNC:31039; LRRN1.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157154; -.
DR HOGENOM; CLU_000288_18_18_1; -.
DR InParanoid; A0N0X6; -.
DR OMA; KTTVRFM; -.
DR OrthoDB; 998247at2759; -.
DR TreeFam; TF334360; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000001176; Expressed in floor plate of diencephalon and 83 other tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01463; LRRCT; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 9.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000250"
FT CHAIN 26..716
FT /note="Leucine-rich repeat neuronal protein 1"
FT /id="PRO_0000273549"
FT TOPO_DOM 26..631
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 632..652
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 653..716
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..72
FT /note="LRRNT"
FT REPEAT 73..95
FT /note="LRR 1"
FT REPEAT 96..117
FT /note="LRR 2"
FT REPEAT 120..141
FT /note="LRR 3"
FT REPEAT 144..165
FT /note="LRR 4"
FT REPEAT 168..189
FT /note="LRR 5"
FT REPEAT 192..213
FT /note="LRR 6"
FT REPEAT 216..237
FT /note="LRR 7"
FT REPEAT 240..261
FT /note="LRR 8"
FT REPEAT 264..285
FT /note="LRR 9"
FT DOMAIN 371..424
FT /note="LRRCT"
FT DOMAIN 424..515
FT /note="Ig-like C2-type"
FT DOMAIN 525..617
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 691..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 385
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 517
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 582
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 611
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 447..499
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 716 AA; 80831 MW; 240365AE4E091E01 CRC64;
MARMSFVLAA YQMVLSLLMT SLTGSSLQSS ECPQLCVCEI RPWFTPQSTY REATTVDCND
LRLTRIPSNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL DFSQNNFTNI KEVGLANLTQ
LTTLHLEENQ ITEMNDYCLQ DLSNLQELYI NHNQISTISA NAFSGLKNLL RLHLNSNKLK
VIDSRWFDST PNLEILMIGE NPVIGILDMN FKPLSNLRSL VLAGMYLTDI PGNALVGLDS
LESLSFYDNK LVKVPQLALQ KVPNLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL
VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN AVYQKTVESL
PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA MPPEYRGQQV KEVLIQDSSE
QCLPMISHDT FPNHLNMDIG TTVFLDCRAM AEPEPEIYWV TPLGNKITVE TLSEKYKLSS
EGTLEISKIQ IEDSGRYTCV AQNVEGADTR VVMIKVNGTL LDGAQVLKIY VKQTESHSIL
VSWKVNSNVM TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN
IHQQTQKSCV NVTTKNAAFA LDISDQETST ALAAVMGSMF AVISLASIAV YIAKRFKRKN
YHHSLKKYMQ KTSSIPLNEL YPPLINLWEG DSEKDKDGTA DTKPTQVDTS RSYYMW
