LRRN1_HUMAN
ID LRRN1_HUMAN Reviewed; 716 AA.
AC Q6UXK5; Q3LID5; Q8IYV5; Q9H8V1; Q9P231;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Leucine-rich repeat neuronal protein 1;
DE AltName: Full=Neuronal leucine-rich repeat protein 1;
DE Short=NLRR-1;
DE Flags: Precursor;
GN Name=LRRN1; Synonyms=KIAA1497; ORFNames=Nbla10449, UNQ693/PRO1338;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neuroblastoma;
RX PubMed=12880961; DOI=10.1016/s0304-3835(03)00085-5;
RA Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S.,
RA Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S.,
RA Hirato J., Nakagawara A.;
RT "Neuroblastoma oligo-capping cDNA project: toward the understanding of the
RT genesis and biology of neuroblastoma.";
RL Cancer Lett. 197:63-68(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 283-716.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP PROTEIN SEQUENCE OF 26-40.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- INTERACTION:
CC Q6UXK5; Q13077: TRAF1; NbExp=3; IntAct=EBI-12136157, EBI-359224;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA96021.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB14500.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB074161; BAE45733.1; -; mRNA.
DR EMBL; AB040930; BAA96021.1; ALT_INIT; mRNA.
DR EMBL; AY358312; AAQ88679.1; -; mRNA.
DR EMBL; BC034947; AAH34947.1; -; mRNA.
DR EMBL; AK023273; BAB14500.1; ALT_INIT; mRNA.
DR CCDS; CCDS33685.1; -.
DR RefSeq; NP_001311117.1; NM_001324188.1.
DR RefSeq; NP_001311118.1; NM_001324189.1.
DR RefSeq; NP_065924.3; NM_020873.6.
DR AlphaFoldDB; Q6UXK5; -.
DR SMR; Q6UXK5; -.
DR BioGRID; 121675; 6.
DR IntAct; Q6UXK5; 5.
DR STRING; 9606.ENSP00000314901; -.
DR CarbonylDB; Q6UXK5; -.
DR GlyGen; Q6UXK5; 4 sites.
DR iPTMnet; Q6UXK5; -.
DR PhosphoSitePlus; Q6UXK5; -.
DR BioMuta; LRRN1; -.
DR DMDM; 60390188; -.
DR EPD; Q6UXK5; -.
DR jPOST; Q6UXK5; -.
DR MassIVE; Q6UXK5; -.
DR MaxQB; Q6UXK5; -.
DR PaxDb; Q6UXK5; -.
DR PeptideAtlas; Q6UXK5; -.
DR PRIDE; Q6UXK5; -.
DR ProteomicsDB; 67634; -.
DR Antibodypedia; 2639; 86 antibodies from 21 providers.
DR DNASU; 57633; -.
DR Ensembl; ENST00000319331.4; ENSP00000314901.3; ENSG00000175928.6.
DR GeneID; 57633; -.
DR KEGG; hsa:57633; -.
DR MANE-Select; ENST00000319331.4; ENSP00000314901.3; NM_020873.7; NP_065924.3.
DR UCSC; uc003bpt.4; human.
DR CTD; 57633; -.
DR DisGeNET; 57633; -.
DR GeneCards; LRRN1; -.
DR HGNC; HGNC:20980; LRRN1.
DR HPA; ENSG00000175928; Tissue enhanced (brain).
DR MIM; 619623; gene.
DR neXtProt; NX_Q6UXK5; -.
DR OpenTargets; ENSG00000175928; -.
DR PharmGKB; PA134935557; -.
DR VEuPathDB; HostDB:ENSG00000175928; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157154; -.
DR HOGENOM; CLU_000288_18_18_1; -.
DR InParanoid; Q6UXK5; -.
DR OMA; KTTVRFM; -.
DR OrthoDB; 998247at2759; -.
DR PhylomeDB; Q6UXK5; -.
DR TreeFam; TF334360; -.
DR PathwayCommons; Q6UXK5; -.
DR SignaLink; Q6UXK5; -.
DR BioGRID-ORCS; 57633; 17 hits in 1065 CRISPR screens.
DR GeneWiki; LRRN1; -.
DR GenomeRNAi; 57633; -.
DR Pharos; Q6UXK5; Tbio.
DR PRO; PR:Q6UXK5; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6UXK5; protein.
DR Bgee; ENSG00000175928; Expressed in ventricular zone and 160 other tissues.
DR Genevisible; Q6UXK5; HS.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 10.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Leucine-rich repeat; Membrane; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 26..716
FT /note="Leucine-rich repeat neuronal protein 1"
FT /id="PRO_0000014847"
FT TOPO_DOM 26..631
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 632..652
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 653..716
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..72
FT /note="LRRNT"
FT REPEAT 73..95
FT /note="LRR 1"
FT REPEAT 96..117
FT /note="LRR 2"
FT REPEAT 120..141
FT /note="LRR 3"
FT REPEAT 144..165
FT /note="LRR 4"
FT REPEAT 168..189
FT /note="LRR 5"
FT REPEAT 192..213
FT /note="LRR 6"
FT REPEAT 216..237
FT /note="LRR 7"
FT REPEAT 240..261
FT /note="LRR 8"
FT REPEAT 264..285
FT /note="LRR 9"
FT REPEAT 313..335
FT /note="LRR 10"
FT REPEAT 338..359
FT /note="LRR 11"
FT DOMAIN 371..424
FT /note="LRRCT"
FT DOMAIN 424..515
FT /note="Ig-like C2-type"
FT DOMAIN 525..617
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 691..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 385
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 517
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 447..499
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 395
FT /note="L -> V (in dbSNP:rs35362954)"
FT /id="VAR_049896"
FT VARIANT 702
FT /note="T -> P (in dbSNP:rs34611357)"
FT /id="VAR_049897"
FT CONFLICT 264
FT /note="N -> S (in Ref. 4; AAH34947)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 716 AA; 80716 MW; A6B84D3C7464799C CRC64;
MARMSFVIAA CQLVLGLLMT SLTESSIQNS ECPQLCVCEI RPWFTPQSTY REATTVDCND
LRLTRIPSNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL DFSQNNFTNI KEVGLANLTQ
LTTLHLEENQ ITEMTDYCLQ DLSNLQELYI NHNQISTISA HAFAGLKNLL RLHLNSNKLK
VIDSRWFDST PNLEILMIGE NPVIGILDMN FKPLANLRSL VLAGMYLTDI PGNALVGLDS
LESLSFYDNK LVKVPQLALQ KVPNLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL
VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN AIYQKTVESL
PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA MPPEYKGHQV KEVLIQDSSE
QCLPMISHDS FPNRLNVDIG TTVFLDCRAM AEPEPEIYWV TPIGNKITVE TLSDKYKLSS
EGTLEISNIQ IEDSGRYTCV AQNVQGADTR VATIKVNGTL LDGTQVLKIY VKQTESHSIL
VSWKVNSNVM TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN
IHQQTQKSCV NVTTKNAAFA VDISDQETST ALAAVMGSMF AVISLASIAV YFAKRFKRKN
YHHSLKKYMQ KTSSIPLNEL YPPLINLWEG DSEKDKDGSA DTKPTQVDTS RSYYMW
