LRRN1_MOUSE
ID LRRN1_MOUSE Reviewed; 716 AA.
AC Q61809; Q3USY1; Q69ZI0;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Leucine-rich repeat neuronal protein 1;
DE AltName: Full=Neuronal leucine-rich repeat protein 1;
DE Short=NLRR-1;
DE Flags: Precursor;
GN Name=Lrrn1; Synonyms=Kiaa1497;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=ICR; TISSUE=Brain;
RX PubMed=8717337; DOI=10.1016/0169-328x(95)00178-u;
RA Taguchi A., Wanaka A., Mori T., Matsumoto K., Imai Y., Takagi T.,
RA Tohyama M.;
RT "Molecular cloning of novel leucine-rich repeat proteins and their
RT expression in the developing mouse nervous system.";
RL Brain Res. Mol. Brain Res. 35:31-40(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreatic islet;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Brain cortex, and Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in brain. {ECO:0000269|PubMed:8717337}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32464.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; D45913; BAA08341.1; -; mRNA.
DR EMBL; AK173186; BAD32464.1; ALT_INIT; mRNA.
DR EMBL; AK139355; BAE23973.1; -; mRNA.
DR EMBL; AK139965; BAE24199.1; -; mRNA.
DR EMBL; AK160841; BAE36040.1; -; mRNA.
DR EMBL; BC031122; AAH31122.1; -; mRNA.
DR EMBL; BC058701; AAH58701.1; -; mRNA.
DR CCDS; CCDS20399.1; -.
DR RefSeq; NP_032542.1; NM_008516.4.
DR AlphaFoldDB; Q61809; -.
DR SMR; Q61809; -.
DR STRING; 10090.ENSMUSP00000037096; -.
DR GlyGen; Q61809; 5 sites.
DR iPTMnet; Q61809; -.
DR PhosphoSitePlus; Q61809; -.
DR MaxQB; Q61809; -.
DR PaxDb; Q61809; -.
DR PRIDE; Q61809; -.
DR ProteomicsDB; 290174; -.
DR ABCD; Q61809; 6 sequenced antibodies.
DR Antibodypedia; 2639; 86 antibodies from 21 providers.
DR DNASU; 16979; -.
DR Ensembl; ENSMUST00000049285; ENSMUSP00000037096; ENSMUSG00000034648.
DR GeneID; 16979; -.
DR KEGG; mmu:16979; -.
DR UCSC; uc009ddd.2; mouse.
DR CTD; 57633; -.
DR MGI; MGI:106038; Lrrn1.
DR VEuPathDB; HostDB:ENSMUSG00000034648; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157154; -.
DR HOGENOM; CLU_000288_18_18_1; -.
DR InParanoid; Q61809; -.
DR OMA; KTTVRFM; -.
DR OrthoDB; 998247at2759; -.
DR PhylomeDB; Q61809; -.
DR TreeFam; TF334360; -.
DR BioGRID-ORCS; 16979; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Lrrn1; mouse.
DR PRO; PR:Q61809; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q61809; protein.
DR Bgee; ENSMUSG00000034648; Expressed in pontine nuclear group and 228 other tissues.
DR Genevisible; Q61809; MM.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01463; LRRCT; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 9.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000250"
FT CHAIN 26..716
FT /note="Leucine-rich repeat neuronal protein 1"
FT /id="PRO_0000014848"
FT TOPO_DOM 26..631
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 632..652
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 653..716
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 26..72
FT /note="LRRNT"
FT REPEAT 73..95
FT /note="LRR 1"
FT REPEAT 96..117
FT /note="LRR 2"
FT REPEAT 120..141
FT /note="LRR 3"
FT REPEAT 144..165
FT /note="LRR 4"
FT REPEAT 168..189
FT /note="LRR 5"
FT REPEAT 192..213
FT /note="LRR 6"
FT REPEAT 216..237
FT /note="LRR 7"
FT REPEAT 240..261
FT /note="LRR 8"
FT REPEAT 264..285
FT /note="LRR 9"
FT DOMAIN 371..424
FT /note="LRRCT"
FT DOMAIN 424..515
FT /note="Ig-like C2-type"
FT DOMAIN 525..619
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 692..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 385
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 517
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 447..499
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 716 AA; 80548 MW; 5073FB4801D08F58 CRC64;
MARLSTGKAA CQVVLGLLIT SLTESSILTS ECPQLCVCEI RPWFTPQSTY REATTVDCND
LRLTRIPGNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL DFSQNNFTNI KEVGLANLTQ
LTTLHLEENQ ISEMTDYCLQ DLSNLQELYI NHNQISTISA NAFSGLKNLL RLHLNSNKLK
VIDSRWFDST PNLEILMIGE NPVIGILDMN FRPLSNLRSL VLAGMYLTDV PGNALVGLDS
LESLSFYDNK LIKVPQLALQ KVPNLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL
VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN AVYQKTVESL
PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA MPPEYRGQQV KEVLIQDSSE
QCLPMISHDT FPNHLNMDIG TTLFLDCRAM AEPEPEIYWV TPIGNKITVE TLSDKYKLSS
EGTLEIANIQ IEDSGRYTCV AQNVQGADTR VATIKVNGTL LDGAQVLKIY VKQTESHSIL
VSWKVNSNVM TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN
IHQQTQKSCV NVTTKTAAFA LDISDHETST ALAAVMGSMF AVISLASIAI YIAKRFKRKN
YHHSLKKYMQ KTSSIPLNEL YPPLINLWEA DSDKDKDGSA DTKPTQVDTS RSYYMW
