LRRN3_HUMAN
ID LRRN3_HUMAN Reviewed; 708 AA.
AC Q9H3W5; O43377; Q6I9V8; Q8IYQ6;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Leucine-rich repeat neuronal protein 3;
DE AltName: Full=Neuronal leucine-rich repeat protein 3;
DE Short=NLRR-3;
DE Flags: Precursor;
GN Name=LRRN3; ORFNames=Nbla10363, UNQ194/PRO220;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Jin L., Yu L., Zhao S.Y.;
RT "Cloning of a new human cDNA homologous to Mus musculus leucine-rich repeat
RT protein.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hamano S., Inuzuka H., Morohashi A., Ohira M., Nakagawara A.;
RT "Human neuronal leucine-rich repeat protein-3 (NLRR-3).";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AF134481; AAP97258.1; -; mRNA.
DR EMBL; AB060967; BAB47184.1; -; mRNA.
DR EMBL; AY358280; AAQ88647.1; -; mRNA.
DR EMBL; CR457397; CAG33678.1; -; mRNA.
DR EMBL; AL442092; CAC09450.1; -; mRNA.
DR EMBL; BC035133; AAH35133.1; -; mRNA.
DR CCDS; CCDS5754.1; -.
DR RefSeq; NP_001093128.1; NM_001099658.1.
DR RefSeq; NP_001093130.1; NM_001099660.1.
DR RefSeq; NP_060804.3; NM_018334.4.
DR AlphaFoldDB; Q9H3W5; -.
DR SMR; Q9H3W5; -.
DR BioGRID; 120095; 9.
DR IntAct; Q9H3W5; 2.
DR STRING; 9606.ENSP00000397312; -.
DR GlyGen; Q9H3W5; 9 sites.
DR PhosphoSitePlus; Q9H3W5; -.
DR BioMuta; LRRN3; -.
DR DMDM; 74761421; -.
DR jPOST; Q9H3W5; -.
DR MassIVE; Q9H3W5; -.
DR MaxQB; Q9H3W5; -.
DR PaxDb; Q9H3W5; -.
DR PeptideAtlas; Q9H3W5; -.
DR PRIDE; Q9H3W5; -.
DR ProteomicsDB; 80766; -.
DR Antibodypedia; 31483; 186 antibodies from 22 providers.
DR DNASU; 54674; -.
DR Ensembl; ENST00000308478.10; ENSP00000312001.5; ENSG00000173114.13.
DR Ensembl; ENST00000422987.3; ENSP00000412417.2; ENSG00000173114.13.
DR Ensembl; ENST00000451085.5; ENSP00000397312.1; ENSG00000173114.13.
DR GeneID; 54674; -.
DR KEGG; hsa:54674; -.
DR MANE-Select; ENST00000308478.10; ENSP00000312001.5; NM_001099658.2; NP_001093128.1.
DR UCSC; uc003vfs.5; human.
DR CTD; 54674; -.
DR DisGeNET; 54674; -.
DR GeneCards; LRRN3; -.
DR HGNC; HGNC:17200; LRRN3.
DR HPA; ENSG00000173114; Tissue enhanced (adrenal gland, thyroid gland).
DR MIM; 619748; gene.
DR neXtProt; NX_Q9H3W5; -.
DR OpenTargets; ENSG00000173114; -.
DR PharmGKB; PA30468; -.
DR VEuPathDB; HostDB:ENSG00000173114; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160513; -.
DR HOGENOM; CLU_000288_18_18_1; -.
DR OMA; DKFYMHP; -.
DR OrthoDB; 998247at2759; -.
DR PhylomeDB; Q9H3W5; -.
DR TreeFam; TF334360; -.
DR PathwayCommons; Q9H3W5; -.
DR SignaLink; Q9H3W5; -.
DR BioGRID-ORCS; 54674; 6 hits in 1068 CRISPR screens.
DR ChiTaRS; LRRN3; human.
DR GeneWiki; LRRN3; -.
DR GenomeRNAi; 54674; -.
DR Pharos; Q9H3W5; Tbio.
DR PRO; PR:Q9H3W5; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9H3W5; protein.
DR Bgee; ENSG00000173114; Expressed in endothelial cell and 185 other tissues.
DR ExpressionAtlas; Q9H3W5; baseline and differential.
DR Genevisible; Q9H3W5; HS.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 10.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..708
FT /note="Leucine-rich repeat neuronal protein 3"
FT /id="PRO_0000045823"
FT TOPO_DOM 23..628
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 629..649
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 650..708
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 23..69
FT /note="LRRNT"
FT REPEAT 70..91
FT /note="LRR 1"
FT REPEAT 93..114
FT /note="LRR 2"
FT REPEAT 117..138
FT /note="LRR 3"
FT REPEAT 141..162
FT /note="LRR 4"
FT REPEAT 165..186
FT /note="LRR 5"
FT REPEAT 189..210
FT /note="LRR 6"
FT REPEAT 213..234
FT /note="LRR 7"
FT REPEAT 237..258
FT /note="LRR 8"
FT REPEAT 261..282
FT /note="LRR 9"
FT REPEAT 285..304
FT /note="LRR 10"
FT REPEAT 310..332
FT /note="LRR 11"
FT REPEAT 335..358
FT /note="LRR 12"
FT DOMAIN 368..421
FT /note="LRRCT"
FT DOMAIN 421..514
FT /note="Ig-like C2-type"
FT DOMAIN 523..617
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 522
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 579
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 608
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 624
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 625
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 444..496
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 24
FT /note="D -> G (in dbSNP:rs9942557)"
FT /id="VAR_049901"
FT CONFLICT 96
FT /note="G -> S (in Ref. 6; AAH35133)"
FT /evidence="ECO:0000305"
FT CONFLICT 533
FT /note="Q -> H (in Ref. 6; AAH35133)"
FT /evidence="ECO:0000305"
FT CONFLICT 541
FT /note="W -> R (in Ref. 4; CAG33678)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 708 AA; 79424 MW; 24710478D6B124D1 CRC64;
MKDMPLRIHV LLGLAITTLV QAVDKKVDCP RLCTCEIRPW FTPRSIYMEA STVDCNDLGL
LTFPARLPAN TQILLLQTNN IAKIEYSTDF PVNLTGLDLS QNNLSSVTNI NVKKMPQLLS
VYLEENKLTE LPEKCLSELS NLQELYINHN LLSTISPGAF IGLHNLLRLH LNSNRLQMIN
SKWFDALPNL EILMIGENPI IRIKDMNFKP LINLRSLVIA GINLTEIPDN ALVGLENLES
ISFYDNRLIK VPHVALQKVV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELISI
DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNSNALSALY HGTIESLPNL
KEISIHSNPI RCDCVIRWMN MNKTNIRFME PDSLFCVDPP EFQGQNVRQV HFRDMMEICL
PLIAPESFPS NLNVEAGSYV SFHCRATAEP QPEIYWITPS GQKLLPNTLT DKFYVHSEGT
LDINGVTPKE GGLYTCIATN LVGADLKSVM IKVDGSFPQD NNGSLNIKIR DIQANSVLVS
WKASSKILKS SVKWTAFVKT ENSHAAQSAR IPSDVKVYNL THLNPSTEYK ICIDIPTIYQ
KNRKKCVNVT TKGLHPDQKE YEKNNTTTLM ACLGGLLGII GVICLISCLS PEMNCDGGHS
YVRNYLQKPT FALGELYPPL INLWEAGKEK STSLKVKATV IGLPTNMS
